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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

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Whats That

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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Hanskri Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lefuhans-20 Tablet

Lefuhans-20 Tablet belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefuhans-20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefuhans-20 Tablet at the same time every day as prescribed by your doctor. In some cases, Lefuhans-20 Tablet may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefuhans-20 Tablet if you are pregnant or planning for pregnancy as Lefuhans-20 Tablet may cause serious congenital disabilities. Lefuhans-20 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefuhans-20 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefuhans-20 Tablet as it could lead to increased dizziness and liver damage. Lefuhans-20 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefuhans-20 Tablet

Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Lefuhans-20 Tablet with or without food. Swallow Lefuhans-20 Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Lefuhans-20 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefuhans-20 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lefuhans-20 Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Drug Warnings

Do not take Lefuhans-20 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefuhans-20 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefuhans-20 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefuhans-20 Tablet may cause dizziness, so drive with caution. Lefuhans-20 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideTamoxifen
Severe
LeflunomideTemozolomide
Severe

Drug-Drug Interactions

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LeflunomideTamoxifen
Severe
How does the drug interact with Lefuhans-20 Tablet:
Taking Lefuhans-20 Tablet with tamoxifen affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking tamoxifen and Lefuhans-20 Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideTemozolomide
Severe
How does the drug interact with Lefuhans-20 Tablet:
Taking Temozolomide with Lefuhans-20 Tablet can increase the risk of infections.

How to manage the interaction:
Although taking temozolomide and Lefuhans-20 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, pain or burning during urination, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting a doctor.
LeflunomideCaspofungin
Severe
How does the drug interact with Lefuhans-20 Tablet:
Lefuhans-20 Tablet can cause liver problems, and combining it with other drugs, such as binimetinib, can raise the risk.

How to manage the interaction:
There may be a possibility of interaction between Lefuhans-20 Tablet and Caspofungin, but it can be taken if prescribed by a doctor. If you have any of these symptoms, contact your doctor right away. These symptoms include liver problems, fever, rash, itching, loss of appetite, dark urine, stomach pain, unusual bleeding or bruising, feeling tired, and yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
LeflunomideAcitretin
Severe
How does the drug interact with Lefuhans-20 Tablet:
Coadministration of Acitretin with Lefuhans-20 Tablet may increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Acitretin and Lefuhans-20 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideBrigatinib
Severe
How does the drug interact with Lefuhans-20 Tablet:
Brigatinib can cause higher levels of Lefuhans-20 Tablet in the blood by reducing its excretion.

How to manage the interaction:
There may be a possibility of interaction between Lefuhans-20 Tablet and Brigatinib, but it can be taken if prescribed by a doctor. If you notice symptoms like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Other symptoms to look out for include diarrhea, shortness of breath, weight loss, and pain or burning while urinating." Do not discontinue any medications without consulting your doctor.
LeflunomideErlotinib
Severe
How does the drug interact with Lefuhans-20 Tablet:
When erlotinib is taken with Lefuhans-20 Tablet, it increases the risk of causing liver problems.

How to manage the interaction:
Although there is a possible interaction between Erlotinib and Lefuhans-20 Tablet, you can take these medicines together if advised by your doctor. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, liver damage, or bleeding, it's important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
LeflunomideCerivastatin
Severe
How does the drug interact with Lefuhans-20 Tablet:
Lefuhans-20 Tablet can cause liver problems, and combining it with other drugs, such as Cerivastatin, can raise the risk.

How to manage the interaction:
Although there is a possible interaction between Lefuhans-20 Tablet and Cerivastatin, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms - fever, joint pain, rash, or stomach pain, contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideTofacitinib
Severe
How does the drug interact with Lefuhans-20 Tablet:
Taking tofacitinib with Lefuhans-20 Tablet can increase the risk of infections.

How to manage the interaction:
Although there is an interaction between Lefuhans-20 Tablet and tofacitinib together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideMycophenolate Mofetil
Severe
How does the drug interact with Lefuhans-20 Tablet:
Using Lefuhans-20 Tablet together with mycophenolate mofetil may increase the risk of developing serious infections.

How to manage the interaction:
Although taking Mycophenolate Mofetil and Lefuhans-20 Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination call a doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideAcarbose
Severe
How does the drug interact with Lefuhans-20 Tablet:
Co-administration of acarbose with Lefuhans-20 Tablet may increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between acarbose and Lefuhans-20 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Lefuhans-20 Tablet Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Lefuhans-20 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

Lefuhans-20 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefuhans-20 Tablet . Take Lefuhans-20 Tablet for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Special Advise

Regular blood tests to monitor your liver function after starting Lefuhans-20 Tablet , and for every 6-8 weeks are advised.

Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (where the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty in moving and swelling. Patients with rheumatoid arthritis have intense joint pain (especially knee joint) with stiffness. 

Psoriatic arthritis: Psoriatic arthritis is an autoimmune disease characterized by inflammation of the skin (psoriasis) and joints (inflammatory arthritis). It mainly affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

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