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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sureshvarma D , MPharma
Non returnable*
COD available

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Manufacturer/Marketer :

Leeford Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Migrafen Tablet

Migrafen Tablet is a combination medicine indicated to treat and prevent migraine. Migrafen Tablet is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack. Migraine is a neurological condition which is characterised by the intense pulsating, throbbing, pounding, debilitating headache which usually occurs on one side of the head; however, it can occur on both sides or shift.
 
Migrafen Tablet is a combination of four drugs, namely: Ergotamine (ergot alkaloid), caffeine (methylxanthine), prochlorperazine (anti-emetic) and paracetamol (analgesic). Ergotamine works by narrowing the blood vessels in the brain, and also affects the blood flow patterns associated with headache. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.
 
You are advised to take Migrafen Tablet for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Migrafen Tablet contains paracetamol, do not take other medicines containing paracetamol along with Migrafen Tablet unless prescribed. Do not take Migrafen Tablet if you are pregnant or breastfeeding. Migrafen Tablet may cause drowsiness and dizziness, so drive with caution. Migrafen Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Migrafen Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Uses of Migrafen Tablet

Migraine

Directions for Use

Take Migrafen Tablet with or without food. Swallow Migrafen Tablet as a whole with a glass of water; do not chew, or break it.

Medicinal Benefits

Migrafen Tablet is a combination of four drugs, namely: Ergotamine, caffeine, prochlorperazine, and paracetamol. Migrafen Tablet is indicated to treat and prevent migraine. Ergotamine is an ergot alkaloid that works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headache. Caffeine is a methylxanthine that enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine is an anti-emetic that prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol is an analgesic that blocks the release of prostaglandins that cause pain. Migrafen Tablet is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Migrafen Tablet if you are allergic to any of its contents; if you have/had heart problems, blood circulation problems or if you are taking antibiotics, anti-fungal, anti-HIV or other anti-migraine medicines. Migrafen Tablet , when taken along with antibiotics, anti-fungal, anti-HIV drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain. Migrafen Tablet contains paracetamol, do not take other medicines containing paracetamol along with Migrafen Tablet unless prescribed. Inform your doctor before taking Migrafen Tablet if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, liver and kidney problems. Do not take Migrafen Tablet if you are pregnant or breastfeeding. Migrafen Tablet may cause drowsiness and dizziness, so drive only if you are alert. Migrafen Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Migrafen Tablet as it could lead to increased drowsiness. Do not take any other NSAIDs for pain relief along with Migrafen Tablet unless prescribed. 

Drug-Drug Interactions

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ProchlorperazineMesoridazine
Critical

Drug-Drug Interactions

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ProchlorperazineMesoridazine
Critical
How does the drug interact with Migrafen Tablet:
Coadministration of mesoridazine and Migrafen Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking mesoridazine with Migrafen Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Migrafen Tablet:
Coadministration of metoclopramide and Migrafen Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Migrafen Tablet together is generally avoided as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience muscle spasm or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult the doctor. Do not stop taking any medications without consulting a doctor.
CaffeinePhenelzine
Critical
How does the drug interact with Migrafen Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Migrafen Tablet with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
CaffeineLinezolid
Critical
How does the drug interact with Migrafen Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Migrafen Tablet with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
Critical
How does the drug interact with Migrafen Tablet:
Coadministration of tranylcypromine with Migrafen Tablet can in cause severe high blood pressure.

How to manage the interaction:
Taking Migrafen Tablet with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
CaffeineIsocarboxazid
Critical
How does the drug interact with Migrafen Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Migrafen Tablet with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
ErgotamineCeritinib
Critical
How does the drug interact with Migrafen Tablet:
Taking Migrafen Tablet with ceritinib can significantly increase the blood levels and effects of Migrafen Tablet.

How to manage the interaction:
Taking Ceritinib with Migrafen Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and trouble speaking. Do not discontinue any medications without consulting a doctor.
ErgotamineClarithromycin
Critical
How does the drug interact with Migrafen Tablet:
When Migrafen Tablet is taken with Clarithromycin, the amount of Migrafen Tablet in the blood can go up.

How to manage the interaction:
Taking Clarithromycin with Migrafen Tablet can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ErgotamineMifepristone
Critical
How does the drug interact with Migrafen Tablet:
When Mifepristone is taken with Migrafen Tablet, it may increase the blood levels of Migrafen Tablet, which may result in side effects.

How to manage the interaction:
Taking Migrafen Tablet with Mifepristone is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
ErgotamineRizatriptan
Critical
How does the drug interact with Migrafen Tablet:
Combining Migrafen Tablet with Rizatriptan can increase the risk of high blood pressure.

How to manage the interaction:
Taking Rizatriptan with Migrafen Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately If you experience symptoms such as severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grape juice or grape fruit can increase the blood levels of ergotamine in the body. Consumption of grape juice increases the effect of caffeine. Limit your consumption of grapefruit and grapefruit juice during treatment with ergotamine and caffeine.

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
  • Avoid bright lights, loud noise, and extreme temperatures.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Massage your scalp to ease the pain.
  • Lie down in a quiet, dark room.
  • Avoid smoking, alcohol, and caffeinated drinks. 
  • Learn what triggers your migraine and try avoiding them.
  • Stay hydrated. Drink plenty of fluids.
  • Learn relaxation skills as they help in reducing stress.

Habit Forming

No

Therapeutic Class

ANTIMIGRAINE AGENTS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Migrafen Tablet contains Ergotamine, caffeine, prochlorperazine, and paracetamol. Ergotamine works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.

Dry mouth could be a side-effect of Migrafen Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Orthostatic hypotension could be a side-effect of Migrafen Tablet . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better.

Do not discontinue Migrafen Tablet without consulting your doctor as it could lead to recurring or worsening of symptoms. To treat your condition effectually, continue taking Migrafen Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Migrafen Tablet .

Do not take Migrafen Tablet along with antibiotics (clarithromycin, erythromycin, troleandomycin), anti-fungal (itraconazole, ketoconazole) and anti-HIV medicines (indinavir, nelfinavir, ritonavir). Migrafen Tablet contains ergotamine and caffeine, which, when taken along with these drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain.

Migrafen Tablet may cause constipation. Eat high-fibre foods and drink plenty of fluids if you experience constipation. Talk to your doctor if the condition persists or worsens.

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • TROLEANDOMYCIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • INDINAVIR
  • NELFINAVIR
  • RITONAVIR
  • OXYMETAZOLINE
  • ACETAMINOPHEN
  • FENTANYL
  • BUTALBITAL
  • FLUOXETINE
  • DULOXETINE
  • DIAZEPAM
  • LORAZEPAM
  • ALPRAZOLAM
  • RANITIDINE
  • DIPHENHYDRAMINE
  • PREGABALIN
  • METOPROLOL
  • ALBUTEROL
  • ONDANSETRON

Disease/Condition Glossary

Migraine: Migraine is a neurological condition which is characterised by an intense, debilitating headache. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, certain foods and drinks can trigger migraine headaches. Migraine headache is preceded by warning symptoms one or two days prior to the headache itself. The warning symptoms include food cravings, depression, fatigue, hyperactivity, irritability, and neck stiffness. Symptoms of migraine include throbbing pain in one area with varying intensity, nausea, vomiting, numbness or tingling sensation, difficulty speaking, and sensitivity to sound and light.

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