Retol-Plus Tablet 10's is a combination medicine indicated to treat and prevent migraine. Retol-Plus Tablet 10's is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack. Migraine is a neurological condition which is characterised by the intense pulsating, throbbing, pounding, debilitating headache which usually occurs on one side of the head; however, it can occur on both sides or shift.
 
Retol-Plus Tablet 10's is a combination of four drugs, namely: Ergotamine (ergot alkaloid), caffeine (methylxanthine), prochlorperazine (anti-emetic) and paracetamol (analgesic). Ergotamine works by narrowing the blood vessels in the brain, and also affects the blood flow patterns associated with headache. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.
 
You are advised to take Retol-Plus Tablet 10's for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Retol-Plus Tablet 10's contains paracetamol, do not take other medicines containing paracetamol along with Retol-Plus Tablet 10's unless prescribed. Do not take Retol-Plus Tablet 10's if you are pregnant or breastfeeding. Retol-Plus Tablet 10's may cause drowsiness and dizziness, so drive with caution. Retol-Plus Tablet 10's should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Retol-Plus Tablet 10's as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Retol-Plus Tablet 10's is a combination of four drugs, namely: Ergotamine, caffeine, prochlorperazine, and paracetamol. Retol-Plus Tablet 10's is indicated to treat and prevent migraine. Ergotamine is an ergot alkaloid that works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headache. Caffeine is a methylxanthine that enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine is an anti-emetic that prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol is an analgesic that blocks the release of prostaglandins that cause pain. Retol-Plus Tablet 10's is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack.

• Stomach upset
• Dizziness
• Dry mouth
• Constipation
• Insomnia (trouble sleeping)

Do not take Retol-Plus Tablet 10's if you are allergic to any of its contents; if you have/had heart problems, blood circulation problems or if you are taking antibiotics, anti-fungal, anti-HIV or other anti-migraine medicines. Retol-Plus Tablet 10's, when taken along with antibiotics, anti-fungal, anti-HIV drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain. Retol-Plus Tablet 10's contains paracetamol, do not take other medicines containing paracetamol along with Retol-Plus Tablet 10's unless prescribed. Inform your doctor before taking Retol-Plus Tablet 10's if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, liver and kidney problems. Do not take Retol-Plus Tablet 10's if you are pregnant or breastfeeding. Retol-Plus Tablet 10's may cause drowsiness and dizziness, so drive only if you are alert. Retol-Plus Tablet 10's is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Retol-Plus Tablet 10's as it could lead to increased drowsiness. Do not take any other NSAIDs for pain relief along with Retol-Plus Tablet 10's unless prescribed. 

Drug-Drug Interactions: Retol-Plus Tablet 10's may interact with antibiotics (clarithromycin, erythromycin, troleandomycin), anti-fungal (itraconazole, ketoconazole), anti-HIV medicines (indinavir, nelfinavir, ritonavir), decongestant (oxymetazoline), pain killers (acetaminophen, butalbital, fentanyl), anti-depressant (fluoxetine, duloxetine), anti-anxiety (diazepam, lorazepam, alprazolam), antacid (ranitidine), antihistamine (diphenhydramine), anti-convulsant (pregabalin), anti-hypertensive (metoprolol), bronchodilators (albuterol), anti-emetic (ondansetron).

Drug-Food Interactions: Avoid the consumption of alcohol, smoking, and caffeinated products. Do not consume grapefruit while taking Retol-Plus Tablet 10's.

Drug-Disease Interactions: Inform your doctor if you have high blood pressure, vasospastic reactions, heart problems, bipolar disorder, psychotic disorders, seizure disorders, gastroesophageal reflux disease, liver or kidney problems.

• CLARITHROMYCIN
• ERYTHROMYCIN
• TROLEANDOMYCIN
• ITRACONAZOLE
• KETOCONAZOLE
• INDINAVIR
• NELFINAVIR
• RITONAVIR
• OXYMETAZOLINE
• ACETAMINOPHEN
• FENTANYL
• BUTALBITAL
• FLUOXETINE
• DULOXETINE
• DIAZEPAM
• LORAZEPAM
• ALPRAZOLAM
• RANITIDINE
• DIPHENHYDRAMINE
• PREGABALIN
• METOPROLOL
• ALBUTEROL
• ONDANSETRON

• Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
• Avoid bright lights, loud noise, and extreme temperatures.
• Perform meditation and yoga. This helps in relieving stress and provides relaxation.
• Follow a regular sleep pattern to improve the amount and quality of sleep you get.
• Massage your scalp to ease the pain.
• Lie down in a quiet, dark room.
• Avoid smoking, alcohol, and caffeinated drinks. 
• Learn what triggers your migraine and try avoiding them.
• Stay hydrated. Drink plenty of fluids.
• Learn relaxation skills as they help in reducing stress.

Migraine: Migraine is a neurological condition which is characterised by an intense, debilitating headache. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, certain foods and drinks can trigger migraine headaches. Migraine headache is preceded by warning symptoms one or two days prior to the headache itself. The warning symptoms include food cravings, depression, fatigue, hyperactivity, irritability, and neck stiffness. Symptoms of migraine include throbbing pain in one area with varying intensity, nausea, vomiting, numbness or tingling sensation, difficulty speaking, and sensitivity to sound and light.