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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sureshvarma D , MPharma
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About Vasograin Tablet 20's

Vasograin Tablet 20's is a combination medicine indicated to treat and prevent migraine. Vasograin Tablet 20's is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack. Migraine is a neurological condition which is characterised by the intense pulsating, throbbing, pounding, debilitating headache which usually occurs on one side of the head; however, it can occur on both sides or shift.
 
Vasograin Tablet 20's is a combination of four drugs, namely: Ergotamine (ergot alkaloid), caffeine (methylxanthine), prochlorperazine (anti-emetic) and paracetamol (analgesic). Ergotamine works by narrowing the blood vessels in the brain, and also affects the blood flow patterns associated with headache. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.
 
You are advised to take Vasograin Tablet 20's for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Vasograin Tablet 20's contains paracetamol, do not take other medicines containing paracetamol along with Vasograin Tablet 20's unless prescribed. Do not take Vasograin Tablet 20's if you are pregnant or breastfeeding. Vasograin Tablet 20's may cause drowsiness and dizziness, so drive with caution. Vasograin Tablet 20's should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Vasograin Tablet 20's as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Uses of Vasograin Tablet 20's

Migraine

Directions for Use

Take Vasograin Tablet 20's with or without food. Swallow Vasograin Tablet 20's as a whole with a glass of water; do not chew, or break it.

Medicinal Benefits

Vasograin Tablet 20's is a combination of four drugs, namely: Ergotamine, caffeine, prochlorperazine, and paracetamol. Vasograin Tablet 20's is indicated to treat and prevent migraine. Ergotamine is an ergot alkaloid that works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headache. Caffeine is a methylxanthine that enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine is an anti-emetic that prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol is an analgesic that blocks the release of prostaglandins that cause pain. Vasograin Tablet 20's is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Vasograin Tablet 20's

  • Stomach upset
  • Dizziness
  • Dry mouth
  • Constipation
  • Insomnia (trouble sleeping)

Drug Warnings

Do not take Vasograin Tablet 20's if you are allergic to any of its contents; if you have/had heart problems, blood circulation problems or if you are taking antibiotics, anti-fungal, anti-HIV or other anti-migraine medicines. Vasograin Tablet 20's, when taken along with antibiotics, anti-fungal, anti-HIV drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain. Vasograin Tablet 20's contains paracetamol, do not take other medicines containing paracetamol along with Vasograin Tablet 20's unless prescribed. Inform your doctor before taking Vasograin Tablet 20's if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, liver and kidney problems. Do not take Vasograin Tablet 20's if you are pregnant or breastfeeding. Vasograin Tablet 20's may cause drowsiness and dizziness, so drive only if you are alert. Vasograin Tablet 20's is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Vasograin Tablet 20's as it could lead to increased drowsiness. Do not take any other NSAIDs for pain relief along with Vasograin Tablet 20's unless prescribed. 

Drug-Drug Interactions

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ProchlorperazineMetoclopramide
Critical
ProchlorperazineMesoridazine
Critical

Drug-Drug Interactions

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ProchlorperazineMetoclopramide
Critical
How does the drug interact with Vasograin Tablet:
Coadministration of metoclopramide and Vasograin Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Vasograin Tablet together is generally avoided as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience muscle spasm or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult the doctor. Do not stop taking any medications without consulting a doctor.
ProchlorperazineMesoridazine
Critical
How does the drug interact with Vasograin Tablet:
Coadministration of mesoridazine and Vasograin Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking mesoridazine with Vasograin Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
CaffeinePhenelzine
Critical
How does the drug interact with Vasograin Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Vasograin Tablet with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
CaffeineTranylcypromine
Critical
How does the drug interact with Vasograin Tablet:
Coadministration of tranylcypromine with Vasograin Tablet can in cause severe high blood pressure.

How to manage the interaction:
Taking Vasograin Tablet with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
CaffeineLinezolid
Critical
How does the drug interact with Vasograin Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Vasograin Tablet with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeineIsocarboxazid
Critical
How does the drug interact with Vasograin Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Vasograin Tablet with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
ErgotamineSumatriptan
Critical
How does the drug interact with Vasograin Tablet:
Coadministration of Vasograin Tablet with Sumatriptan can reduce blood flow and increase the risk of serious side effects such as high blood pressure or heart-related disorders.

How to manage the interaction:
There may be a possibility of interaction between Sumatriptan and Vasograin Tablet, but it can be taken if prescribed by a doctor. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, call a doctor. Do not discontinue any medication without consulting a doctor.
ErgotamineRizatriptan
Critical
How does the drug interact with Vasograin Tablet:
Combining Vasograin Tablet with Rizatriptan can increase the risk of high blood pressure.

How to manage the interaction:
Taking Rizatriptan with Vasograin Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately If you experience symptoms such as severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech. Do not discontinue any medications without consulting a doctor.
ErgotamineCeritinib
Critical
How does the drug interact with Vasograin Tablet:
Taking Vasograin Tablet with ceritinib can significantly increase the blood levels and effects of Vasograin Tablet.

How to manage the interaction:
Taking Ceritinib with Vasograin Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and trouble speaking. Do not discontinue any medications without consulting a doctor.
ErgotamineVoriconazole
Critical
How does the drug interact with Vasograin Tablet:
The serum concentration of Ergometrine can be increased when it is combined with Voriconazole.

How to manage the interaction:
Taking Vasograin Tablet with Voriconazole is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grape juice or grape fruit can increase the blood levels of ergotamine in the body. Consumption of grape juice increases the effect of caffeine. Limit your consumption of grapefruit and grapefruit juice during treatment with ergotamine and caffeine.

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
  • Avoid bright lights, loud noise, and extreme temperatures.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Massage your scalp to ease the pain.
  • Lie down in a quiet, dark room.
  • Avoid smoking, alcohol, and caffeinated drinks. 
  • Learn what triggers your migraine and try avoiding them.
  • Stay hydrated. Drink plenty of fluids.
  • Learn relaxation skills as they help in reducing stress.

Habit Forming

No

Therapeutic Class

ANTIMIGRAINE AGENTS

Vasograin Tablet 20's Substitute

Substitutes safety advice
  • Vasograin Tablet 14's

    by Others

    8.68per tablet
  • Migrafen Tablet 10's

    by Others

    10.80per tablet
  • Nt Grain Tablet 10's

    by Others

    4.77per tablet
  • Migrarest Tablet 10's

    by Others

    8.42per tablet
  • Antigrain Tablet

    by Others

    5.80per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Vasograin Tablet 20's contains Ergotamine, caffeine, prochlorperazine, and paracetamol. Ergotamine works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.

Dry mouth could be a side-effect of Vasograin Tablet 20's. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Orthostatic hypotension could be a side-effect of Vasograin Tablet 20's. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better.

Do not discontinue Vasograin Tablet 20's without consulting your doctor as it could lead to recurring or worsening of symptoms. To treat your condition effectually, continue taking Vasograin Tablet 20's for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Vasograin Tablet 20's.

Do not take Vasograin Tablet 20's along with antibiotics (clarithromycin, erythromycin, troleandomycin), anti-fungal (itraconazole, ketoconazole) and anti-HIV medicines (indinavir, nelfinavir, ritonavir). Vasograin Tablet 20's contains ergotamine and caffeine, which, when taken along with these drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain.

Vasograin Tablet 20's may cause constipation. Eat high-fibre foods and drink plenty of fluids if you experience constipation. Talk to your doctor if the condition persists or worsens.

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • TROLEANDOMYCIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • INDINAVIR
  • NELFINAVIR
  • RITONAVIR
  • OXYMETAZOLINE
  • ACETAMINOPHEN
  • FENTANYL
  • BUTALBITAL
  • FLUOXETINE
  • DULOXETINE
  • DIAZEPAM
  • LORAZEPAM
  • ALPRAZOLAM
  • RANITIDINE
  • DIPHENHYDRAMINE
  • PREGABALIN
  • METOPROLOL
  • ALBUTEROL
  • ONDANSETRON

Disease/Condition Glossary

Migraine: Migraine is a neurological condition which is characterised by an intense, debilitating headache. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, certain foods and drinks can trigger migraine headaches. Migraine headache is preceded by warning symptoms one or two days prior to the headache itself. The warning symptoms include food cravings, depression, fatigue, hyperactivity, irritability, and neck stiffness. Symptoms of migraine include throbbing pain in one area with varying intensity, nausea, vomiting, numbness or tingling sensation, difficulty speaking, and sensitivity to sound and light.

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