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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sureshvarma D , MPharma

About Migrarest Tablet 10's

Migrarest Tablet 10's is a combination medicine indicated to treat and prevent migraine. Migrarest Tablet 10's is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack. Migraine is a neurological condition which is characterised by the intense pulsating, throbbing, pounding, debilitating headache which usually occurs on one side of the head; however, it can occur on both sides or shift.
 
Migrarest Tablet 10's is a combination of four drugs, namely: Ergotamine (ergot alkaloid), caffeine (methylxanthine), prochlorperazine (anti-emetic) and paracetamol (analgesic). Ergotamine works by narrowing the blood vessels in the brain, and also affects the blood flow patterns associated with headache. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.
 
You are advised to take Migrarest Tablet 10's for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Migrarest Tablet 10's contains paracetamol, do not take other medicines containing paracetamol along with Migrarest Tablet 10's unless prescribed. Do not take Migrarest Tablet 10's if you are pregnant or breastfeeding. Migrarest Tablet 10's may cause drowsiness and dizziness, so drive with caution. Migrarest Tablet 10's should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Migrarest Tablet 10's as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

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Non returnable*
COD available

Online payment accepted

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Migrarest Tablet 10's

Migraine

Medicinal Benefits

Migrarest Tablet 10's is a combination of four drugs, namely: Ergotamine, caffeine, prochlorperazine, and paracetamol. Migrarest Tablet 10's is indicated to treat and prevent migraine. Ergotamine is an ergot alkaloid that works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headache. Caffeine is a methylxanthine that enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine is an anti-emetic that prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol is an analgesic that blocks the release of prostaglandins that cause pain. Migrarest Tablet 10's is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack.

Side Effects of Migrarest Tablet 10's

  • Stomach upset
  • Dizziness
  • Dry mouth
  • Constipation
  • Insomnia (trouble sleeping)

Directions for Use

Take Migrarest Tablet 10's with or without food. Swallow Migrarest Tablet 10's as a whole with a glass of water; do not chew, or break it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Migrarest Tablet 10's if you are allergic to any of its contents; if you have/had heart problems, blood circulation problems or if you are taking antibiotics, anti-fungal, anti-HIV or other anti-migraine medicines. Migrarest Tablet 10's, when taken along with antibiotics, anti-fungal, anti-HIV drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain. Migrarest Tablet 10's contains paracetamol, do not take other medicines containing paracetamol along with Migrarest Tablet 10's unless prescribed. Inform your doctor before taking Migrarest Tablet 10's if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, liver and kidney problems. Do not take Migrarest Tablet 10's if you are pregnant or breastfeeding. Migrarest Tablet 10's may cause drowsiness and dizziness, so drive only if you are alert. Migrarest Tablet 10's is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Migrarest Tablet 10's as it could lead to increased drowsiness. Do not take any other NSAIDs for pain relief along with Migrarest Tablet 10's unless prescribed. 

Therapeutic Class

ANTIMIGRAINE AGENTS

Drug-Drug Interactions

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ProchlorperazineMetoclopramide
Critical
ProchlorperazineMesoridazine
Critical

Drug-Drug Interactions

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ProchlorperazineMetoclopramide
Critical
How does the drug interact with Migrarest Tablet 10's:
Coadministration of metoclopramide and Migrarest Tablet 10's can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Migrarest Tablet 10's together is generally avoided as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience muscle spasm or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult the doctor. Do not stop taking any medications without consulting a doctor.
ProchlorperazineMesoridazine
Critical
How does the drug interact with Migrarest Tablet 10's:
Coadministration of mesoridazine and Migrarest Tablet 10's can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking mesoridazine with Migrarest Tablet 10's is not recommended, but it can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
CaffeineIsocarboxazid
Critical
How does the drug interact with Migrarest Tablet 10's:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Migrarest Tablet 10's with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeineLinezolid
Critical
How does the drug interact with Migrarest Tablet 10's:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Migrarest Tablet 10's with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeinePhenelzine
Critical
How does the drug interact with Migrarest Tablet 10's:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Migrarest Tablet 10's with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
CaffeineTranylcypromine
Critical
How does the drug interact with Migrarest Tablet 10's:
Coadministration of tranylcypromine with Migrarest Tablet 10's can in cause severe high blood pressure.

How to manage the interaction:
Taking Migrarest Tablet 10's with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
ErgotamineRitonavir
Critical
How does the drug interact with Migrarest Tablet 10's:
Taking Migrarest Tablet 10's with ritonavir may significantly increase the blood levels and effects of Migrarest Tablet 10's.

How to manage the interaction:
Taking Migrarest Tablet 10's with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor. Do not discontinue any medications without consulting a doctor.
ErgotamineClarithromycin
Critical
How does the drug interact with Migrarest Tablet 10's:
When Migrarest Tablet 10's is taken with Clarithromycin, the amount of Migrarest Tablet 10's in the blood can go up.

How to manage the interaction:
Taking Clarithromycin with Migrarest Tablet 10's can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ErgotamineSumatriptan
Critical
How does the drug interact with Migrarest Tablet 10's:
Coadministration of Migrarest Tablet 10's with Sumatriptan can reduce blood flow and increase the risk of serious side effects such as high blood pressure or heart-related disorders.

How to manage the interaction:
There may be a possibility of interaction between Sumatriptan and Migrarest Tablet 10's, but it can be taken if prescribed by a doctor. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, call a doctor. Do not discontinue any medication without consulting a doctor.
ErgotamineBromocriptine
Critical
How does the drug interact with Migrarest Tablet 10's:
When these medications are taken combined, they can have an additive effect, causing severe constriction of blood vessels and decreased blood flow to the vital organs, which increases the risk of side effects.

How to manage the interaction:
Co-administration of Bromocriptine with Migrarest Tablet 10's can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include pain in chest, severe stomach pain, feeling sick, numbness or tingling, muscle pain or weakness, fingers or toes turning blue or purple, pale or cold skin, chest pain, irregular heartbeat, intense headache, difficulty breathing, blurry vision, confusion, or trouble speaking clearly. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grape juice or grape fruit can increase the blood levels of ergotamine in the body. Consumption of grape juice increases the effect of caffeine. Limit your consumption of grapefruit and grapefruit juice during treatment with ergotamine and caffeine.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • TROLEANDOMYCIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • INDINAVIR
  • NELFINAVIR
  • RITONAVIR
  • OXYMETAZOLINE
  • ACETAMINOPHEN
  • FENTANYL
  • BUTALBITAL
  • FLUOXETINE
  • DULOXETINE
  • DIAZEPAM
  • LORAZEPAM
  • ALPRAZOLAM
  • RANITIDINE
  • DIPHENHYDRAMINE
  • PREGABALIN
  • METOPROLOL
  • ALBUTEROL
  • ONDANSETRON

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
  • Avoid bright lights, loud noise, and extreme temperatures.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Massage your scalp to ease the pain.
  • Lie down in a quiet, dark room.
  • Avoid smoking, alcohol, and caffeinated drinks. 
  • Learn what triggers your migraine and try avoiding them.
  • Stay hydrated. Drink plenty of fluids.
  • Learn relaxation skills as they help in reducing stress.

Habit Forming

No

Author Details

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Disease/Condition Glossary

Migraine: Migraine is a neurological condition which is characterised by an intense, debilitating headache. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, certain foods and drinks can trigger migraine headaches. Migraine headache is preceded by warning symptoms one or two days prior to the headache itself. The warning symptoms include food cravings, depression, fatigue, hyperactivity, irritability, and neck stiffness. Symptoms of migraine include throbbing pain in one area with varying intensity, nausea, vomiting, numbness or tingling sensation, difficulty speaking, and sensitivity to sound and light.

Migrarest Tablet 10's Substitute

Substitutes safety advice
  • Vasograin Tablet 14's

    8.68per tablet
  • Migrafen Tablet 10's

    10.80per tablet
  • Nt Grain Tablet 10's

    4.77per tablet
  • Migraine Relief Tablet 10's

    7.20per tablet
  • Migrapac Tablet 10's

    7.34per tablet
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