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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sureshvarma D , MPharma
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About Neuromol Plus Tablet

Neuromol Plus Tablet is a combination medicine indicated to treat and prevent migraine. Neuromol Plus Tablet is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack. Migraine is a neurological condition which is characterised by the intense pulsating, throbbing, pounding, debilitating headache which usually occurs on one side of the head; however, it can occur on both sides or shift.
 
Neuromol Plus Tablet is a combination of four drugs, namely: Ergotamine (ergot alkaloid), caffeine (methylxanthine), prochlorperazine (anti-emetic) and paracetamol (analgesic). Ergotamine works by narrowing the blood vessels in the brain, and also affects the blood flow patterns associated with headache. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.
 
You are advised to take Neuromol Plus Tablet for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as stomach upset, dizziness, dry mouth, constipation, and insomnia (trouble sleeping). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Neuromol Plus Tablet contains paracetamol, do not take other medicines containing paracetamol along with Neuromol Plus Tablet unless prescribed. Do not take Neuromol Plus Tablet if you are pregnant or breastfeeding. Neuromol Plus Tablet may cause drowsiness and dizziness, so drive with caution. Neuromol Plus Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Neuromol Plus Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Uses of Neuromol Plus Tablet

Migraine

Directions for Use

Take Neuromol Plus Tablet with or without food. Swallow Neuromol Plus Tablet as a whole with a glass of water; do not chew, or break it.

Medicinal Benefits

Neuromol Plus Tablet is a combination of four drugs, namely: Ergotamine, caffeine, prochlorperazine, and paracetamol. Neuromol Plus Tablet is indicated to treat and prevent migraine. Ergotamine is an ergot alkaloid that works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headache. Caffeine is a methylxanthine that enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine is an anti-emetic that prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol is an analgesic that blocks the release of prostaglandins that cause pain. Neuromol Plus Tablet is used to relieve the symptoms at the first sign of a migraine attack and to prevent the worsening of the attack.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Neuromol Plus Tablet if you are allergic to any of its contents; if you have/had heart problems, blood circulation problems or if you are taking antibiotics, anti-fungal, anti-HIV or other anti-migraine medicines. Neuromol Plus Tablet, when taken along with antibiotics, anti-fungal, anti-HIV drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain. Neuromol Plus Tablet contains paracetamol, do not take other medicines containing paracetamol along with Neuromol Plus Tablet unless prescribed. Inform your doctor before taking Neuromol Plus Tablet if you have/had high blood pressure, heart problems, high cholesterol, diabetes, asthma, liver and kidney problems. Do not take Neuromol Plus Tablet if you are pregnant or breastfeeding. Neuromol Plus Tablet may cause drowsiness and dizziness, so drive only if you are alert. Neuromol Plus Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Neuromol Plus Tablet as it could lead to increased drowsiness. Do not take any other NSAIDs for pain relief along with Neuromol Plus Tablet unless prescribed. 

Drug-Drug Interactions

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ProchlorperazineMesoridazine
Critical

Drug-Drug Interactions

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ProchlorperazineMesoridazine
Critical
How does the drug interact with Neuromol Plus Tablet:
Coadministration of mesoridazine and Neuromol Plus Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking mesoridazine with Neuromol Plus Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Neuromol Plus Tablet:
Coadministration of metoclopramide and Neuromol Plus Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Neuromol Plus Tablet together is generally avoided as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience muscle spasm or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult the doctor. Do not stop taking any medications without consulting a doctor.
CaffeinePhenelzine
Critical
How does the drug interact with Neuromol Plus Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Neuromol Plus Tablet with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
CaffeineIsocarboxazid
Critical
How does the drug interact with Neuromol Plus Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Neuromol Plus Tablet with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
Critical
How does the drug interact with Neuromol Plus Tablet:
Coadministration of tranylcypromine with Neuromol Plus Tablet can in cause severe high blood pressure.

How to manage the interaction:
Taking Neuromol Plus Tablet with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
CaffeineLinezolid
Critical
How does the drug interact with Neuromol Plus Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Neuromol Plus Tablet with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
ErgotamineMifepristone
Critical
How does the drug interact with Neuromol Plus Tablet:
When Mifepristone is taken with Neuromol Plus Tablet, it may increase the blood levels of Neuromol Plus Tablet, which may result in side effects.

How to manage the interaction:
Taking Neuromol Plus Tablet with Mifepristone is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
ErgotamineSumatriptan
Critical
How does the drug interact with Neuromol Plus Tablet:
Coadministration of Neuromol Plus Tablet with Sumatriptan can reduce blood flow and increase the risk of serious side effects such as high blood pressure or heart-related disorders.

How to manage the interaction:
There may be a possibility of interaction between Sumatriptan and Neuromol Plus Tablet, but it can be taken if prescribed by a doctor. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, call a doctor. Do not discontinue any medication without consulting a doctor.
ErgotamineCeritinib
Critical
How does the drug interact with Neuromol Plus Tablet:
Taking Neuromol Plus Tablet with ceritinib can significantly increase the blood levels and effects of Neuromol Plus Tablet.

How to manage the interaction:
Taking Ceritinib with Neuromol Plus Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience severe abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, irregular heartbeat, severe headache, shortness of breath, blurred vision, confusion, and trouble speaking. Do not discontinue any medications without consulting a doctor.
ErgotamineItraconazole
Critical
How does the drug interact with Neuromol Plus Tablet:
The blood levels and effects of Neuromol Plus Tablet may be greatly increased when combined with itraconazole.

How to manage the interaction:
Neuromol Plus Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you experience a severe headache, shortness of breath, blurred vision, confusion, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of the fingers or toes, pale or cold skin, or chest pain or tightness. Without first consulting your doctor, never stop taking medicines.

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate

Drug-Food Interactions

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CAFFEINE-100MG+ERGOTAMINE-1MG+PARACETAMOL-250MG+PROCHLORPERAZINE-2.5MGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grape juice or grape fruit can increase the blood levels of ergotamine in the body. Consumption of grape juice increases the effect of caffeine. Limit your consumption of grapefruit and grapefruit juice during treatment with ergotamine and caffeine.

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
  • Avoid bright lights, loud noise, and extreme temperatures.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Massage your scalp to ease the pain.
  • Lie down in a quiet, dark room.
  • Avoid smoking, alcohol, and caffeinated drinks. 
  • Learn what triggers your migraine and try avoiding them.
  • Stay hydrated. Drink plenty of fluids.
  • Learn relaxation skills as they help in reducing stress.

Habit Forming

No

Therapeutic Class

ANTIMIGRAINE AGENTS

Neuromol Plus Tablet Substitute

Substitutes safety advice
  • Vasograin Tablet 14's

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    8.68per tablet
  • Vasograin Tablet 20's

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    10.55per tablet
  • Migrafen Tablet 10's

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    10.80per tablet
  • Nt Grain Tablet 10's

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    4.77per tablet
  • Migrarest Tablet 10's

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    8.42per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Neuromol Plus Tablet contains Ergotamine, caffeine, prochlorperazine, and paracetamol. Ergotamine works by narrowing the blood vessels in the brain and also affects the blood flow patterns associated with headaches. Caffeine enhances the vasoconstrictive effect (narrowing of blood vessels). Prochlorperazine prevents nausea and vomiting associated with migraine by modifying the effects of neurotransmitters. Paracetamol blocks the release of prostaglandins that cause pain.

Dry mouth could be a side-effect of Neuromol Plus Tablet. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Orthostatic hypotension could be a side-effect of Neuromol Plus Tablet. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better.

Do not discontinue Neuromol Plus Tablet without consulting your doctor as it could lead to recurring or worsening of symptoms. To treat your condition effectually, continue taking Neuromol Plus Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Neuromol Plus Tablet.

Do not take Neuromol Plus Tablet along with antibiotics (clarithromycin, erythromycin, troleandomycin), anti-fungal (itraconazole, ketoconazole) and anti-HIV medicines (indinavir, nelfinavir, ritonavir). Neuromol Plus Tablet contains ergotamine and caffeine, which, when taken along with these drugs, could lead to unpleasant side-effects such as poor blood flow to hands, feet, or brain.

Neuromol Plus Tablet may cause constipation. Eat high-fibre foods and drink plenty of fluids if you experience constipation. Talk to your doctor if the condition persists or worsens.

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • TROLEANDOMYCIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • INDINAVIR
  • NELFINAVIR
  • RITONAVIR
  • OXYMETAZOLINE
  • ACETAMINOPHEN
  • FENTANYL
  • BUTALBITAL
  • FLUOXETINE
  • DULOXETINE
  • DIAZEPAM
  • LORAZEPAM
  • ALPRAZOLAM
  • RANITIDINE
  • DIPHENHYDRAMINE
  • PREGABALIN
  • METOPROLOL
  • ALBUTEROL
  • ONDANSETRON

Disease/Condition Glossary

Migraine: Migraine is a neurological condition which is characterised by an intense, debilitating headache. Hormonal changes, stress, lack or excess of sleep, bright lights, loud sounds, certain foods and drinks can trigger migraine headaches. Migraine headache is preceded by warning symptoms one or two days prior to the headache itself. The warning symptoms include food cravings, depression, fatigue, hyperactivity, irritability, and neck stiffness. Symptoms of migraine include throbbing pain in one area with varying intensity, nausea, vomiting, numbness or tingling sensation, difficulty speaking, and sensitivity to sound and light.

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