Aceclofenac+paracetamol+chlorzoxazone
About
Aceclofenac+paracetamol+chlorzoxazone is a combination drug that belongs to NSAIDs (non-steroidal anti-inflammatory drugs) or pain killers primarily used for pain relief and muscle relaxation. Muscle pain (myalgia) is widespread and generally refers to uncomfortable sensations in the muscles which can be due to illness, injury or excessive exercise. It can be continuous or can also occur at intervals.
Aceclofenac+paracetamol+chlorzoxazone contains three medicines, namely: Aceclofenac (pain killer), Paracetamol (fever reducer/mild pain reliever) and Chlorzoxazone (muscle relaxant). Aceclofenac and Paracetamol together work by blocking the effect of a natural chemical messenger called cyclo-oxygenase (COX) enzymes that make another chemical (prostaglandins). These prostaglandins are produced at sites of damage or injury and cause inflammation and pain. On the other hand, Chlorzoxazone is a muscle relaxant that works by centrally acting on the spinal cord by depressing reflexes, thereby relieving pain and stiffness caused due to muscle strains and sprains.
Aceclofenac+paracetamol+chlorzoxazone can be taken with or without food as advised by your doctor for the best results. Do not stop taking Aceclofenac+paracetamol+chlorzoxazone even if you feel better to avoid any unpleasant side effects. Common side effects of Aceclofenac+paracetamol+chlorzoxazone include nausea, vomiting, heartburn, stomach pain, diarrhoea, and loss of appetite. If any of these side effects get worse or do not subside, please visit your doctor immediately.
Aceclofenac+paracetamol+chlorzoxazone should not be taken if you have any serious medical condition, severe kidney or liver disease, are planning to become pregnant or are pregnant. Also, consumption of alcohol should be avoided while taking Aceclofenac+paracetamol+chlorzoxazone as it may increase the drowsiness and dizziness. So, driving a motor vehicle and operating heavy machinery should be avoided. Excess of paracetamol intake can cause liver damage so; its dose should not exceed more than 4 gm per day.
Uses of Aceclofenac+paracetamol+chlorzoxazone
Medicinal Benefits
Aceclofenac and Paracetamol together work by blocking the effect of a natural chemical messenger called cyclo-oxygenase (COX) enzymes that make another chemical (prostaglandins). These prostaglandins are produced at sites of damage or injury and cause inflammation and pain. On the other hand, Chlorzoxazone is a muscle relaxant that works by centrally acting on the spinal cord by depressing reflexes, thereby relieving pain and stiffness caused due to muscle strains and sprains.
Directions for Use
Storage
Side Effects of Aceclofenac+paracetamol+chlorzoxazone
- Nausea
- Vomiting
- Heartburn
- Stomach pain
- Diarrhoea
- Loss of appetite
- Tiredness
- Sleepiness
In-Depth Precautions and Warning
Drug Warnings
Aceclofenac+paracetamol+chlorzoxazone should not be taken if you have any serious medical condition, severe kidney or liver disease, are planning to become pregnant or are pregnant. Also, consumption of alcohol should be avoided while taking Aceclofenac+paracetamol+chlorzoxazone as it may increase the drowsiness and dizziness. So, driving a motor vehicle and operating heavy machinery should be avoided. Excess of paracetamol intake can cause liver damage so; its dose should not exceed more than 4 gm per day.
Drug Interactions
Drug-Drug Interactions: Aceclofenac+paracetamol+chlorzoxazone interacts with sleeping pills (alprazolam, escitalopram, zolpidem), pain killers (tramadol, oxycodone, hydrocodone), antiepileptics or medicines for fits (gabapentin, topiramate, pregabalin), diuretics or water pills (fluoxetine), an antidepressant (duloxetine), antiallergic (diphenhydramine, cetirizine), muscle relaxant and antispasmodic (baclofen).
Drug-Food Interactions: St. John's wort (a herbal supplement) used as an antidepressant can interact with Aceclofenac+paracetamol+chlorzoxazone and cause dizziness, so its usage should be avoided with Aceclofenac+paracetamol+chlorzoxazone.
Drug-Disease Interactions: People with alcoholism, liver disease, kidney disease, stomach ulcer/bleeding, and intestinal ulcer/bleeding should avoid using Aceclofenac+paracetamol+chlorzoxazone.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAceclofenac+paracetamol+chlorzoxazone with alcohol can cause liver problems, so should not be taken until prescribed if you are taking alcohol.
Pregnancy
safe if prescribedOnly consume Aceclofenac+paracetamol+chlorzoxazone, if you are prescribed by a doctor.
Breast Feeding
safe if prescribedOnly consume Aceclofenac+paracetamol+chlorzoxazone, if you are prescribed by a doctor
Driving
unsafeAceclofenac+paracetamol+chlorzoxazone can impair the ability to drive. So, do not drive or operate heavy machinery that required mental alertness after taking Aceclofenac+paracetamol+chlorzoxazone.
Liver
cautionAceclofenac+paracetamol+chlorzoxazone to be taken with caution, especially if you have a history of liver diseases/conditions. Dose may have to be adjusted by your doctor.
Kidney
cautionAceclofenac+paracetamol+chlorzoxazone to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.
Children
safe if prescribedAceclofenac+paracetamol+chlorzoxazone is not recommended for children below the age of 10 years. The safety and effectivenss of Aceclofenac+paracetamol+chlorzoxazone has not been established in children due to limited testing of this drug on children by competent authorities across the world.
Habit Forming
Diet & Lifestyle Advise
- Try to increase the consumption of calcium and vitamin D, as recommended as part of a healthy bone diet.
- Omega 3 fatty acid oils enriched food should include in your daily meal for keeping joints healthy.
- Connective tissues are the “cellular glue” that connects and support vital organs in the body. This connective tissue is comprised of proteins like collagen and elastin. So the requirement of proteins are required for keeping your muscle healthy, so intake of high protein diets like fish (salmon, sardines, and tuna), chicken, and eggs for non-vegetarian. While legumes, nuts, seed and dairy items (milk, yoghurt, cheese) for a vegetarian person is recommended.
- Magnesium, Vitamin K and Zinc enriched foods can help in keeping your bones and muscle healthy so its intake should be enhanced in your daily diet plan.
- Physical activities like Tai chi, Yoga, swimming and walking have shown improvement in managing muscle pain.
- Do not sit for a longer duration. Try to take a gap of 10 minutes by brisk walking or stretching.
Patients Concern
Disease/Condition Glossary
Musculoskeletal pain: It is a pain of bones, muscles, the tissues connecting to muscle-muscle and bone-muscle (cartilage, tendon) and nerves which can be felt just in one area of the body, like low back pain. This type of pain can be felt throughout the body if widespread as in the case of fibromyalgia. The musculoskeletal pain can range from mild/moderate to severe enough, which is sufficient to interfere with your daily routine. It can short-lived (acute) as well as can continue for more than 3-6 months (chronic). The most common musculoskeletal pain includes muscle pain (myalgia) from an injury, spasm, infection, or cramp. Loss of blood flow to the muscle can be one of the cause for muscle pain and inflammation. Joint pain due to rheumatoid arthritis (immune disorder) and osteoarthritis can be another contributing factor in causing the pain. Another pain-inducing factor can be nerve compression pain due to high pressure on the nerves.
FAQs
No, do not suddenly stop taking Aceclofenac+paracetamol+chlorzoxazone. If you want to stop taking this medicine, consult your doctor and he might gradually reduce the dose to avoid unwanted increase in pain or inflammation.
Yes, Aceclofenac+paracetamol+chlorzoxazone is known to cause nausea or vomiting. In order to avoid the same, you should take Aceclofenac+paracetamol+chlorzoxazone with milk or food. In case you are still experiencing excessive nausea while consuming Aceclofenac+paracetamol+chlorzoxazone, speak with your doctor right away.
No, Aceclofenac+paracetamol+chlorzoxazone does not cure Rheumatoid arthritis, but instead, helps in reducing the pain and inflammation caused by it as it an analgesic for a short time.
Taking Aceclofenac+paracetamol+chlorzoxazone with alcohol can damage your liver if taken in excess quantity and also lead to excessive drowsiness. However your alcohol amount should not exceed more than 14 units of alcohol per week.
Patients with mild to moderate renal impairment should be kept under surveillance. The lowest effective dose should be used and renal function monitored regularly. Effects on renal function are usually reversible on withdrawal of Aceclofenac+paracetamol+chlorzoxazone.
No, Aceclofenac+paracetamol+chlorzoxazone is not recommended for stomach pain. This medication can increase the secretion of stomach acid and can cause stomach ulcer and bleeding. So, if you have any gastrointestinal ulcer or bleeding problem or liver issue, speak to your doctor before using Aceclofenac+paracetamol+chlorzoxazone.
