Aceclofenac+serratiopeptidase
About
Aceclofenac+serratiopeptidase belongs to a group of medicines called 'Non-Steroidal Anti-Inflammatory Drugs' (NSAIDs) used to provide pain relief in various conditions including post-traumatic pain, low back pain, cervical pain, spondylitis, osteoarthritis, rheumatoid arthritis. Pain can be temporary (acute) or prolonged period (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone or organs. Chronic pain lasts for life long caused due to nerve damage, osteoarthritis and dental pain due to damage to the tooth nerve, infection, extraction or injury.
Aceclofenac+serratiopeptidase contains two medicines, namely Aceclofenac and Serratiopeptidase. Aceclofenac works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2, responsible for pain, swelling and inflammation. On the other hand, Serratiopeptidase is a proteolytic enzyme that helps break the insoluble protein (fibrin) by-product of blood clot into smaller units. It also causes thinning of the fluids in the body due to injury, thereby making fluid drainage smoother in the swollen tissue. Together Aceclofenac+serratiopeptidase is effective for relieving pain, especially in joint condition.
You are advised to take Aceclofenac+serratiopeptidase for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience nausea, vomiting, loss of appetite (feeling not hungry), heartburn, stomach pain, indigestion, diarrhoea. Most of these side effects of Aceclofenac+serratiopeptidase do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Do not take Aceclofenac+serratiopeptidase if you are pregnant or breastfeeding unless prescribed by the doctor. Aceclofenac+serratiopeptidase may cause drowsiness and dizziness, so drive with caution. Aceclofenac+serratiopeptidase should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol, and Aceclofenac+serratiopeptidase as it could lead to increased drowsiness and dizziness; it might also increase stomach bleeding risk. Aceclofenac+serratiopeptidase should not be given to children as the safety and effectiveness were not established.
Uses of Aceclofenac+serratiopeptidase
Medicinal Benefits
Aceclofenac+serratiopeptidase is used to provide pain relief in various conditions including post-traumatic pain, low back pain, cervical pain, spondylitis (inflammation in spinal bones), osteoarthritis (lifelong joint pain and stiffness), rheumatoid arthritis (joint pain and damage throughout the body), and migraine. Aceclofenac+serratiopeptidase plays a vital role in reducing pain and inflammation by blocking the release of chemical messengers that cause pain and inflammation. This helps in reducing mild to moderate pain and inflammation at the injured or damaged site. Serratiopeptidase is a proteolytic enzyme that helps break the insoluble protein (fibrin) by-product of blood clots into smaller units. It also causes thinning of the fluids in the body due to injury, thereby making fluid drainage smoother in the swollen tissue.
Directions for Use
Storage
Side Effects of Aceclofenac+serratiopeptidase
- Nausea
- Vomiting
- Loss of appetite
- Heartburn
- Stomach pain
- Indigestion
- Diarrhoea
In-Depth Precautions and Warning
Drug Warnings
Do not take Aceclofenac+serratiopeptidase if you are allergic to Aceclofenac+serratiopeptidase or other painkillers. Aceclofenac+serratiopeptidase should not be taken in the conditions like stomach ulcers, bleeding problems, clotting problems, or severe heart, liver, or kidney problems. Inform your doctor before taking Aceclofenac+serratiopeptidase if you have or had disorders of the stomach, blood circulation problems to the brain, asthma, angioedema (swelling under the skin), skin rashes, diabetes, high blood pressure, auto-immune diseases, and connective tissue diseases. Stop taking Aceclofenac+serratiopeptidase and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Inform your doctor if you are recovering from major surgery or if you are more than 65 years of age. Do not take Aceclofenac+serratiopeptidase if you are pregnant or breastfeeding unless prescribed. Aceclofenac+serratiopeptidase may cause drowsiness and dizziness, so drive only if you are alert. Aceclofenac+serratiopeptidase should not be given to children as safety has not been established. Avoid consuming alcohol along with Aceclofenac+serratiopeptidase as it could lead to increased drowsiness and can increase the risk of stomach bleeding.
Drug Interactions
Drug-Drug Interaction: Aceclofenac+serratiopeptidase may have interaction with pain killers (aspirin, ibuprofen, naproxen, celecoxib, etoricoxib), anti-depressants (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, lithium), cardiac glycoside (digoxin), anti-hypertensives (enalapril, lisinopril, losartan, candesartan, hydralazine, methyldopa, clonidine, moxonidine, propranolol), blood thinners (warfarin, heparin, clopidogrel), anti-rheumatoid (methotrexate), steroids (mifepristone).
Drug-Food Interaction: Drinking alcohol should be avoided while taking Aceclofenac+serratiopeptidase as it can cause unpleasant effects.
Drug-Disease Interaction: Aceclofenac+serratiopeptidase should be used with caution in patients with stomach ulcers or bleeding, severe kidney disease, liver diseases, and colitis (inflammation of the large intestine).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended not to consume alcohol along with Aceclofenac+serratiopeptidase to avoid unpleasant side-effects like increased risk of stomach bleeding.
Pregnancy
unsafeThe use of Aceclofenac+serratiopeptidase may impair female fertility and is not recommended in pregnant women or those planning for pregnancy.
Breast Feeding
unsafeAceclofenac+serratiopeptidase contains serratiopeptidase, which may pass into the breast milk. So, it is not recommended for nursing mothers.
Driving
unsafeAceclofenac+serratiopeptidase may affect driving as it causes dizziness. So do not drive a motor vehicle or operate heavy machinery after taking Aceclofenac+serratiopeptidase.
Liver
cautionDose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
unsafeAceclofenac+serratiopeptidase should not be given to children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
- Performing yoga may also help in improving joint flexibility and pain management.
- Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
- Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
- Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
- De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.
- Acupuncture, massage, and physical therapy may also be helpful.
- Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
- Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.
- Avoid smoking and alcohol consumption.
Patients Concern
Disease/Condition Glossary
Musculoskeletal pain: Different types of musculoskeletal pain are caused due to soft tissues (muscle, tendon, and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains, trauma, or post-surgery may require a prolonged amount of time to heal. Different types of musculoskeletal pain are caused due to soft tissues (muscle, tendon, and ligaments). Extreme tissue pain and inflammation are caused due to sprains, strains, or trauma, or post-surgery. These types of injuries may require a prolonged amount of time to heal.
Osteoarthritis: This is a common type of arthritis in which the cartilage that cushions the bones' ends erodes due to wear and tear over time. Common symptoms are joint pain and stiffness.
Rheumatoid arthritis (RA): It is an autoimmune disease in which the immune cells attack the joints and cause bone erosion leading to severe pain and swelling. It may lead to joint deformity if left untreated.
Ankylosing spondylitis: It is a type of arthritis in which inflammation is seen in the spine and large joints. It led to pain and stiffness in the back and affected joints.
Gout: An inflammatory condition in which uric acid deposits and crystallizes in the joints. It is characterized by acute, severe, and recurring pain attacks, especially at night; redness, and swelling in the affected joints.
FAQs
Aceclofenac+serratiopeptidase is a combination of two medicines that include aceclofenac and serratiopeptidase. Aceclofenac+serratiopeptidase contains ‘aceclofenac’ which works by blocking the release of a chemical messenger called prostaglandin, produced by COX-2 in the brain, responsible for pain, swelling, and inflammation. On the other hand, Aceclofenac+serratiopeptidase contains serratiopeptidase, which reduces swelling and inflammation through proteins' breakdown. Thus Aceclofenac+serratiopeptidase helps to relieve musculoskeletal pain and in various joints conditions.
Do not take Aceclofenac+serratiopeptidase for longer durations as it might increase the risk of heart problems and stomach bleeding. Do not exceed the dose and duration of treatment as prescribed by the doctor.
Diarrhea might be a side-effect of Aceclofenac+serratiopeptidase. Drink enough fluids and eat fiber-rich food if you experience diarrhea. If you find blood in stools (tarry stools) or if you experience excess diarrhea consult your doctor. Do not take anti-diarrheal medicine on your own.
Ankylosing spondylitis is arthritis of the spine that can lead to the vertebrae's fusion, leading to pain and inflammation in the spine (vertebrae).
Avoid or limit consumption of alcohol with Aceclofenac+serratiopeptidase as it increases the chances of stomach ulcers and bleeding. It may also lead to increased dizziness and drowsiness.
The most common side effects of Aceclofenac+serratiopeptidase are nausea, vomiting, loss of appetite (feeling not hungry), heartburn, stomach pain, indigestion, diarrhea. Most of these side effects of Aceclofenac+serratiopeptidase do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Serrapeptase is a proteolytic enzyme (protein breaking) derived from silkworms used to treat inflammation and pain following surgery, joint pain, dental surgery and other medical purposes.
