Adapalene+clindamycin
About
Adapalene+clindamycin belongs to the class of dermatological preparations called 'antiacne' used to treat acne (pimples). Acne is a skin condition that is common and occurs when hair follicles are blocked with dead skin cells and oil. The acne-causing bacteria feeds on sebum (natural oil produced by skin) causing redness and swelling.
Adapalene+clindamycin is a combination of two medicines, namely: Adapalene (human-made vitamin A) and Clindamycin (antibiotic). Adapalene (human-made vitamin A) works by loosening the cells on the skin’s surface and unblocks pores by reducing the production of oil in the skin thereby reducing the formation of pimples, whiteheads, and blackheads on the skin surface. Clindamycin belongs to the class of antibiotics that works by inhibiting the production of essential proteins that are necessary for bacteria to grow, multiply and increase in numbers. Altogether it stops or slows down the growth of bacteria and prevents the growth of acne.
Adapalene+clindamycin is only for external use. Take a small amount of Adapalene+clindamycin on the finger and apply it as a thin layer on the clean and dry affected area. Avoid contact of Adapalene+clindamycin with nose, ears, mouth, or eyes. In case Adapalene+clindamycin comes in contact with these areas accidentally, rinse with warm water thoroughly. Your doctor will advise you how often you take Adapalene+clindamycin based on your medical condition. In some cases, you may experience skin peeling, dry skin, irritation, redness, itching, or burning sensation at the site of application. Most of these side effects of Adapalene+clindamycin do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are known to be allergic to Adapalene+clindamycin or any other medicines, please tell your doctor. Do not apply Adapalene+clindamycin to cuts, open wounds, broken, sunburnt or sensitive areas of skin. Avoid sun exposure while using Adapalene+clindamycin as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn. If you are pregnant or breastfeeding, please inform your doctor before taking Adapalene+clindamycin. Do not apply Adapalene+clindamycin in large amounts or use for a long time than prescribed as it does not give quick or better results but increases the risk of side effects such as redness, irritation, skin peeling, or discomfort. If you have intestine problems or eczema, please inform your doctor before taking Adapalene+clindamycin.
Uses of Adapalene+clindamycin
Medicinal Benefits
Adapalene+clindamycin is a combination of two drugs; namely, Adapalene and Clindamycin used to treat acne (pimples). Adapalene is a retinoid (human-made vitamin A) that loosens the cells in the skin’s surface and unblocks pores by reducing the production of oil in the skin. Thereby, decreases pimples, spots, whiteheads and blackheads. Also, Adapalene increases the production of new skin cells and helps in natural exfoliation (removal of dead skin cells) of outer layers of the skin. Clindamycin is a broad-spectrum antibiotic that acts against both aerobic (grow in the presence of oxygen) and anaerobic (grow in the absence of oxygen) gram-negative and gram-positive bacteria. Clindamycin inhibits the production of essential proteins that are necessary for bacteria to grow, multiply and increase in numbers. Together it stops or slows down the growth of bacteria, causing acne and heals the skin by reducing swelling and redness.
Directions for Use
Storage
Side Effects of Adapalene+clindamycin
- Skin peeling
- Dry skin
- Irritation, redness, itching or burning sensation at the site of application
In-Depth Precautions and Warning
Drug Warnings
If you are known to be allergic to Adapalene+clindamycin or any other medicines, please tell your doctor. Do not apply Adapalene+clindamycin to cuts, open wounds, broken, sunburnt or sensitive areas of skin. Avoid sun exposure while using Adapalene+clindamycin as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn. If you are pregnant or breastfeeding, please inform your doctor before taking Adapalene+clindamycin. Do not apply Adapalene+clindamycin in large amounts or use for a long time than prescribed as it does not give quick or better results but increases the risk of side effects such as redness, irritation, skin peeling, or discomfort. If you have intestine problems or eczema, please inform your doctor before taking Adapalene+clindamycin.
Drug Interactions
Drug-Drug Interaction: Adapalene+clindamycin may interact with vitamin A-related drugs known as retinoids (isotretinoin), photosensitizing agents (aminolevulinic acid, methoxsalen), keratolytic agents (benzoyl peroxide, salicylic acid), skeletal muscle relaxants (atracurium, cisatracurium, doxacurium, pancuronium).
Drug- Food Interaction: If you are taking grapefruit juice, St. John’s Wort (herbal medicine to treat depression), yoghurt or alcohol, please inform your doctor before taking Adapalene+clindamycin.
Drug-Disease Interaction: If you have intestine problems or eczema, please inform your doctor before taking Adapalene+clindamycin.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionInteraction of Adapalene+clindamycin with alcohol is unknown. Please consult a doctor before consuming alcohol while using Adapalene+clindamycin.
Pregnancy
cautionThe safety of Adapalene+clindamycin in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks benefits outweigh risks.
Breast Feeding
cautionDo not apply Adapalene+clindamycin on the breast. You are advised to breastfeed only if the doctor thinks benefits are greater than risks.
Driving
safe if prescribedAdapalene+clindamycin usually does not affect your ability to drive or operate machinery.
Liver
safe if prescribedIf you have any concerns regarding the use of Adapalene+clindamycin in patients with Liver problems, please consult a doctor.
Kidney
safe if prescribedIf you have any concerns regarding the use of Adapalene+clindamycin in patients with kidney problems, please consult a doctor.
Children
unsafeAdapalene+clindamycin is not recommended for children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Avoid sun exposure while using Adapalene+clindamycin as it may make the skin more sensitive to sunlight and cause sunburn. Try to wear protective clothing and use sunscreen while going out to protect your skin from sunburn.
- Regular exercise can improve your mood and self-esteem though it doesn’t clear acne. Take a shower immediately after finishing exercise as sweat may irritate acne.
- Do regular hair wash regularly and avoid hair falling across the face.
- Remove the make-up completely before going to bed.
- Avoid using products that may cause skin irritation such as harsh soaps, skin cleansers, shampoos, hair removers or waxes, hair colouring or permanent chemicals, detergents, and rough fabrics.
Special Advise
- You are advised to apply any other lotions, creams o,r ointments including cosmetics and moisturizers after 30 minutes of applying Adapalene+clindamycin as using both at the same time may reduce the effectiveness of Adapalene+clindamycin.
- Avoid contact of Adapalene+clindamycin with nose, mouth, eyes o,r ears. In case Adapalene+clindamycin comes in contact with these areas accidentally, rinse with water.
- Do not squeeze, pop or pick spots as it may worsen them and cause permanent scarring.
Patients Concern
Disease/Condition Glossary
Acne (pimples): It is a common skin condition that occurs when hair follicles are blocked with dead skin cells and oil, causing pimples, whiteheads, and blackheads. Acne affects people of all ages but is most common among teenagers. The symptoms of acne include pus-filled pimples, uninflamed (not swollen) blackheads, red, large, and tender bumps. The treatment for acne includes certain creams, cleansers and antibiotics.
FAQs
Yes, Adapalene+clindamycin may cause photosensitivity (increased skin sensitivity to sunlight) in the treated areas. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use a sunscreen and wear protective clothing while going out to prevent sunburn.
No, Adapalene+clindamycin is not recommended for eczema (itchy, cracked, swollen or rough skin) patients as it may increase the risk of severe irritation. Therefore, if you are suffering from eczema, inform your doctor before using Adapalene+clindamycin.
Yes, Adapalene+clindamycin may cause skin irritation or sensitivity as a side effect. However, if the irritation persists or worsens, stop using Adapalene+clindamycin and consult a doctor.
You are advised to use other acne products with Adapalene+clindamycin cautiously as some products may increase side effects. It is recommended to use Adapalene+clindamycin at night and other products in the morning. However, please consult a doctor before using any other medicines or products with Adapalene+clindamycin.
Yes, Adapalene+clindamycin may cause dryness of the skin. You can use a moisturizer while using Adapalene+clindamycin to prevent dry skin. However, do not apply Adapalene+clindamycin and moisturizer at the same time as it may reduce the effectiveness of Adapalene+clindamycin. Please consult a doctor before using other products with Adapalene+clindamycin.
No, you are not recommended to stop taking Adapalene+clindamycin without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Adapalene+clindamycin for as long as your doctor has prescribed it, and if you experience any difficulty while taking Adapalene+clindamycin, please consult your doctor.
