Ademetionine

Do not take Ademetionine if you are allergic to any of its contents, if you have used an MAO inhibitor in the past 14 days, if the inflammation of gall bladder and bile ducts, narrowing or blockage of bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer. Inform your doctor if you have heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, or kidney and liver problems. Do not take Ademetionine if you are pregnant or breastfeeding unless advised by your doctor. Ademetionine can be given to children with caution if recommended by the doctor. Avoid consuming alcohol along with Ademetionine as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any unpleasant side effects.

Drug-Drug Interactions: Ademetionine may have interaction with monoamine oxidase inhibitors (medicines used to treat depression) (moclobemide, phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, selegiline), an antidepressant (bupropion, duloxetine, fluoxetine, sertraline), antiparkinsons (levodopa), pain killers (tramadol, trazodone, hydrocodone, oxycodone, acetaminophen).

Food-Drug Interactions: No interactions found/established.

Drug-Disease Interactions: Ademetionine may interact with bipolar depression, Parkinson's disease, biliary obstruction and liver impairment, variceal bleeding (high blood pressure in portal veins), ascites (excess abdominal fluid), and liver encephalopathy.

Liver disease:

• Include foods such as bell peppers, citrus fruits, leafy vegetables, tomatoes, milk, fish, low-fat dairy, beans, nuts, lentils, tofu, and tempeh in your diet.
• Foods rich in vitamins B and C and calcium are good for the gallbladder.
• Plant-based protein foods such as beans, nuts, lentils, tofu, and tempeh help prevent gallbladder disease.
• Avoid high-fat, trans-fat, processed foods, white bread, white pasta, and sugars.
• Avoid tobacco and alcohol consumption.

Depression:

• Maintaining a healthy diet and regular exercise helps improve overall health and boost self-esteem.
• Perform meditation and yoga. This helps in relieving stress and provides relaxation.
• Follow a regular sleep pattern to improve the amount and quality of sleep you get.
• Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help properly maintain neurotransmitters. 
• Avoid smoking and alcohol consumption.

Osteoarthritis:

• Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20minutes regularly.

• Your doctor may advise a regular liver function test to monitor the liver's function and the treatment progress.
• Do not use Ademetionine if you have used an MAO inhibitor (antidepressant) in the past 14 days, as a dangerous drug interaction could occur.