Amlodipine+hydrochlorothiazide+olmesartan
About
Amlodipine+hydrochlorothiazide+olmesartan is an 'anti-hypertensives' medication primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. High blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it increases the risk of heart-related diseases like heart attack, heart failure, stroke, irregular heartbeat and other complications.
Amlodipine+hydrochlorothiazide+olmesartan is a combination of three medicines: Amlodipine, Hydrochlorothiazide and Olmesartan. Amlodipine is a calcium channel blocker that dilates (widens) blood vessels and increases blood flow. Altogether, it helps to lower high blood pressure, chest pain (angina) and other conditions caused by coronary artery disease. Hydrochlorothiazide is a diuretic or water pill that works by removing extra water/fluid and certain electrolyte overload from the body. Together, Amlodipine+hydrochlorothiazide+olmesartan lowers fluid overload, raises blood pressure, improves blood flow and reduces the future risk of a heart attack and stroke. On the other hand, Olmesartan is an angiotensin receptor blocker (ARB) that blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently.
You can take Amlodipine+hydrochlorothiazide+olmesartan with food or without food with a glass of water. Do not chew, bite or break it. Your doctor will advise you on how often you take your tablets based on your medical condition. In some cases, you may experience nausea, upset stomach, dehydration, headache, diarrhoea, electrolyte imbalance, dizziness and decreased blood pressure. Most of these side effects of Amlodipine+hydrochlorothiazide+olmesartan do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Do not use potassium supplements or salt substitutes unless your doctor tells you. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not take this Amlodipine+hydrochlorothiazide+olmesartan if you have diabetes mellitus, liver and kidney problems and low blood pressure. If you notice unexplained muscle pain, dark colour urine, tenderness or weakness, especially if you also have a fever or unexplained tiredness, immediately contact the doctor. If you have any allergy to amlodipine, hydrochlorothiazide, and olmesartan, then do not take this Amlodipine+hydrochlorothiazide+olmesartan. Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase heart disease and stroke risk. Inform your doctor if you are suffering from kidney, liver, heart disease, or diabetes.
Uses of Amlodipine+hydrochlorothiazide+olmesartan
Medicinal Benefits
Amlodipine+hydrochlorothiazide+olmesartan is a combination of three medicines: Amlodipine, Hydrochlorothiazide, and Olmesartan. Amlodipine is a calcium channel blocker that dilates (widens) blood vessels and increases blood flow. Altogether, it helps to lower high blood pressure, chest pain (angina) and other conditions caused by coronary artery disease. Hydrochlorothiazide is a diuretic or water pill that works by removing extra water/fluid and certain electrolyte overload from the body. Together, Amlodipine+hydrochlorothiazide+olmesartan lowers fluid overload, raises blood pressure, improves blood flow and reduces the future risk of a heart attack and stroke. On the other hand, Olmesartan is an angiotensin receptor blocker (ARB) that blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently.
Directions for Use
Storage
Side Effects of Amlodipine+hydrochlorothiazide+olmesartan
- Nausea
- Stuffy nose/sore throat
- Upset stomach
- Diarrhoea
- Headache
- Dizziness
- High level of uric acid
- Electrolyte imbalance
- Dehydration.
- Decreased blood pressure
In-Depth Precautions and Warning
Drug Warnings
Do not use Amlodipine+hydrochlorothiazide+olmesartan if you are pregnant, planning for pregnancy, or unable to urinate (anuria). If you have diabetes and taking Amlodipine+hydrochlorothiazide+olmesartan with other blood pressure-lowering pills like 'aliskiren', immediately stop taking both together and consult a doctor. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart) and aortic stenosis (heart valve problem). Amlodipine+hydrochlorothiazide+olmesartan may pass into breast milk, so before starting Amlodipine+hydrochlorothiazide+olmesartan, either you need to stop nursing or you should not take Amlodipine+hydrochlorothiazide+olmesartan while breastfeeding. Please inform your doctor before surgery if you are taking Amlodipine+hydrochlorothiazide+olmesartan as it needs to be stopped because it might lower the blood pressure further if taken along with local anaesthesia. Avoid potassium salt or its substitute intake while using Amlodipine+hydrochlorothiazide+olmesartan to avoid any electrolyte imbalance.
Drug Interactions
Drug-Drug interactions: Amlodipine+hydrochlorothiazide+olmesartan may interact with an antidepressant (lithium), antidiabetic medicines (metformin, insulin), drugs used to treat erectile dysfunction (sildenafil), medications used to lower cholesterol levels (simvastatin), immunosuppressants (cyclosporine), other anti-hypertensive medicines (atenolol, aliskiren, enalapril, lisinopril, ramipril, metoprolol) and pain killers (ibuprofen).
Drug-Food Interactions: Minimize high potassium foods intake and avoid over-the-counter potassium supplements, grapefruit or grapefruit juice.
Drug-Disease Interactions: Amlodipine+hydrochlorothiazide+olmesartan may interact with disease conditions, including low blood pressure, heart, and kidney, difficulty in urination, liver problems or severe dehydration, hyperkalemia (high potassium levels in the blood), and diabetes should consult the doctor before taking Amlodipine+hydrochlorothiazide+olmesartan.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended not to consume alcohol and Amlodipine+hydrochlorothiazide+olmesartan to avoid unpleasant side effects like drowsiness, dizziness and liver damage.
Pregnancy
unsafeAmlodipine+hydrochlorothiazide+olmesartan is not recommended during pregnancy as it is a category D pregnancy drug. This medicine may cause fetal damage and can affect the unborn baby (fetus).
Breast Feeding
unsafeAmlodipine+hydrochlorothiazide+olmesartan is known to pass breast milk, but its effect on the baby is not known. So, before breastfeeding, let your doctor know about this. Either you need to stop breastfeeding for using Amlodipine+hydrochlorothiazide+olmesartan, or you need to stop takingAmlodipine+hydrochlorothiazide+olmesartan.
Driving
cautionDrive with caution, Amlodipine+hydrochlorothiazide+olmesartan usually causes drowsiness and affects driving ability.
Liver
cautionAmlodipine+hydrochlorothiazide+olmesartan to be taken with caution, especially if you have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.
Kidney
cautionAmlodipine+hydrochlorothiazide+olmesartan to be taken with caution, especially if you have had a history of kidney disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.
Children
unsafeEfficacy and safety of Amlodipine+hydrochlorothiazide+olmesartan have not been established in children. If prescribed, it should be strictly under medical supervision and only if the benefits outweigh the harms.
Habit Forming
Diet & Lifestyle Advise
- Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are highly antioxidants.
- Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.
- Use healthy cooking oils like soybean, olive, canola, and coconut oil.
- You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
- Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
- Avoid the consumption of too much salt or salty food.
- Keep your weight under control with a BMI of 19.5-24.9.
- Regular physical activity or exercise like walking improves your blood flow.
- Elevate your legs or the swollen area on a chair or pillow.
- Avoid standing or sitting for extended periods.
- Avoid chronic stress, as it can raise your blood pressure.
- Spend time with your loved ones to cope with stress and practice mindfulness techniques.
- Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.
Special Advise
- Keep a check on your daily blood pressure, and if you notice any fluctuations, please consult a doctor. A low salt/sodium diet and regular exercise are recommended along with Amlodipine+hydrochlorothiazide+olmesartan for effective results.
- If you have diabetes and taking Amlodipine+hydrochlorothiazide+olmesartan with other blood pressure-lowering pills like 'aliskiren', immediately stop taking both together and consult a doctor, as it may cause serious complications.
- Use of Amlodipine+hydrochlorothiazide+olmesartan is not recommended during the 1st trimester of pregnancy and is contraindicated during the 2nd and 3rd trimesters.
Patients Concern
Disease/Condition Glossary
Hypertension: The blood exerts increased pressure on the walls of blood vessels leading to hypertension. High blood pressure is expressed as systolic/diastolic pressure. Systolic pressure is the pressure in the arteries when the heart beats or pumps out blood. Diastolic pressure is the pressure in the arteries between the heartbeats. Blood pressure is measured in millimetres of mercury (mmHg) by a blood pressure monitor called a sphygmomanometer. Some of the symptoms are headache, dizziness, nosebleeds, altered vision, chest pain, weakness, and shortness of breath. However, most of the time, the signs and symptoms of hypertension are none.
FAQs
Amlodipine+hydrochlorothiazide+olmesartan is a combination of three medicines: Amlodipine, Hydrochlorothiazide and Olmesartan. Amlodipine is a calcium channel blocker that dilates (widens) blood vessels and increases blood flow. Altogether, it helps to lower high blood pressure, chest pain (angina) and other conditions caused by coronary artery disease. Hydrochlorothiazide is a diuretic or water pill that works by removing extra water/fluid and certain electrolyte overload from the body. Together, Amlodipine+hydrochlorothiazide+olmesartan lowers fluid overload, raises blood pressure, improves blood flow and reduces the future risk of a heart attack and stroke. On the other hand, Olmesartan is an angiotensin receptor blocker (ARB) that blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. This allows the blood to flow more smoothly in the blood vessels, and the heart can pump more efficiently.
In case you have missed a dose of Amlodipine+hydrochlorothiazide+olmesartan, you are advised to take it as soon as you remember. However, try not to miss a dose in the first place, if it's time for you to take your next dose, then do not take both the doses together. Take only one dose, taking a double dose of Amlodipine+hydrochlorothiazide+olmesartan will lead to low blood pressure.
Do not use Amlodipine+hydrochlorothiazide+olmesartan if you are pregnant, planning for pregnancy or unable to urinate. If you have diabetes and taking Amlodipine+hydrochlorothiazide+olmesartan with other blood pressure-lowering pills like 'aliskiren', immediately stop taking both together and consult a doctor.
Your doctor will check your blood potassium levels regularly for high levels of potassium. Make sure not to miss any future meetings with the doctor.
You may experience fluid loss or dehydration while using Amlodipine+hydrochlorothiazide+olmesartan. To avoid this condition, it is advisable to drink a lot of fluid and water, especially in summer. If you are a kidney patient, please consult a doctor before drinking or increasing any fluid intake.
Yes, the use of a Amlodipine+hydrochlorothiazide+olmesartan can make you feel dizzy. This may occur when you suddenly rise from a sitting or lying position. To lower the chance of feeling dizzy or passing out, rise slowly if you have been lying down or sitting.
