Atropine+diphenoxylate+furazolidone

Atropine+diphenoxylate+furazolidone may cause severe bowel problems, especially in patients with ulcerative colitis (inflammation of the colon). So, inform your doctor if you experience bloating, constipation, vomiting, or stomach pain while using this medicine. Atropine+diphenoxylate+furazolidone may cause atropine toxicity, so inform your doctor if you notice dizziness, headache, muscle cramps, high fever, decrease in urine volume, painful urination, decrease in the frequency of urination, dry skin, and dry mouth. It should be used with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency as this medicine may cause mild anemia.

Drug-Drug Interactions: Atropine+diphenoxylate+furazolidone when used along with medicines that affect the central nervous system (brain and spinal cord) may worsen the side-effects. Some examples of medicines that affect CNS are antiallergic medicines (diphenhydramine, cetirizine), sleeping pills (alprazolam), antidepressants (isocarboxazid, tranylcypromine), narcotic pain killers (morphine), and anesthetics, etc. Atropine+diphenoxylate+furazolidone may interact with medications used to treat muscle weakness (ambenonium), medicines used to treat alcohol dependence (naltrexone and nalmefene), and medicine used to treat Parkinson’s disease (safinamide).

Drug-Food Interactions: Avoid consumption of foods with high tyramine content such as cheese, yeast, smoked meat, poultry, or fish. Avoid avocado, bitter orange, caffeinated beverages, and alcohol consumption while using this medicine. Avoid taking the above foods at least for 2 weeks after stopping this medicine.

Drug-Disease Interactions: Atropine+diphenoxylate+furazolidone should not be used in patients with obstructive jaundice (blockage of bile flow out of liver). It should be used with caution in patients with liver or kidney disease, myasthenia gravis (severe muscle weakness), glaucoma (an eye disease), enlarged prostate, gallbladder problems, difficulty passing urine, blockage or severe inflammation in the intestine or stomach, thyroid problems, and Down’s syndrome (a genetic disorder that causes growth delay in children).

• Do not drink or eat many caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. Atropine+diphenoxylate+furazolidone may increase nervousness, sleeplessness, and anxiety caused by caffeine. Avoid foods that are rich in tyramine, such as cheese, yeast, poultry, and fish.
• Probiotics should be taken after taking the full course of Atropine+diphenoxylate+furazolidone to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like yogurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine’s good bacteria.
• Include more fiber-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet. Make sure you drink plenty of water or other fluids every day while you are taking Atropine+diphenoxylate+furazolidone.
• Avoid alcoholic beverages with Atropine+diphenoxylate+furazolidone as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Atropine+diphenoxylate+furazolidone in fighting off infections.

• Your doctor may check your health condition for the progress and unwanted effects during regular visits.
• In general, diarrhea improves within 2 days of treatment. However, you should complete the course of therapy to treat the condition completely. If the symptoms don’t improve or worsen after 10 days of treatment, consult your doctor immediately.