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ATROPINE+DIPHENOXYLATE+FURAZOLIDONE

About

ATROPINE+DIPHENOXYLATE+FURAZOLIDONE belongs to the class of medicines called ‘antidiarrheal’ used to treat severe diarrhea that occurs due to infections. Diarrhea is a condition in which bowel movements are too frequent, leading to loose and watery stools. In general, infection of the digestive tract is the common cause of diarrhea. Bacteria, parasites, or worms can cause infection.

ATROPINE+DIPHENOXYLATE+FURAZOLIDONE contains Diphenoxylate, Atropine, and Furazolidone. Diphenoxylate works by slowing down intestinal movements, thereby it makes the stools more solid and less frequent. Atropine helps to prevent involuntary muscle movements in the intestine. Atropine is added to prevent the abuse of diphenoxylate as higher doses may cause physical dependence. Furazolidone works by interfering with protein synthesis, a mechanism that is important for the survival of bacteria.

You should take this medicine exactly as prescribed by the doctor. The common side-effects of ATROPINE+DIPHENOXYLATE+FURAZOLIDONE are abdominal discomfort, nausea, vomiting, headache, dry mouth, and dizziness. These side effects are usually mild and temporary. However, if any of these side effects persist or get worse, inform your doctor immediately.

It is not recommended to take ATROPINE+DIPHENOXYLATE+FURAZOLIDONE if you are allergic to any contents of it. ATROPINE+DIPHENOXYLATE+FURAZOLIDONE should not be used in patients with obstructive jaundice (blockage of bile flow out of the liver). Before taking ATROPINE+DIPHENOXYLATE+FURAZOLIDONE, inform your doctor if you have liver or kidney disease, myasthenia gravis (severe muscle weakness), glaucoma (an eye disease), enlarged prostate, gallbladder problems, difficulty passing urine, blockage, or severe inflammation in the intestine or stomach, thyroid problems, and Down’s syndrome (a genetic disorder that causes growth delay in children). ATROPINE+DIPHENOXYLATE+FURAZOLIDONE is not recommended for use in children below 13 years of age as the safety and efficacy have not been studied. ATROPINE+DIPHENOXYLATE+FURAZOLIDONE is not recommended for use in pregnant and breastfeeding women unless clinically needed. Do not consume alcohol as it may worsen the condition. ATROPINE+DIPHENOXYLATE+FURAZOLIDONE may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.  

Uses of ATROPINE+DIPHENOXYLATE+FURAZOLIDONE

Diarrhoea

Medicinal Benefits

ATROPINE+DIPHENOXYLATE+FURAZOLIDONE is used to treat diarrhea caused by infection of the digestive tract. It can effectively control bowel movements, treat infection, and prevent the recurrence of symptoms. It is usually prescribed along with fluid and electrolyte therapy. It is also advised to take plenty of fluids to prevent dehydration.

Directions for Use

Swallow ATROPINE+DIPHENOXYLATE+FURAZOLIDONE as a whole with a glass of water. Do not crush, chew, or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of ATROPINE+DIPHENOXYLATE+FURAZOLIDONE

  • Abdominal discomfort
  • Nausea
  • Vomiting
  • Headache
  • Blurred vision
  • Dry mouth
  • Dizziness
  • Confusion
  • Difficulty in micturation

In-Depth Precautions and Warning

Drug Warnings

ATROPINE+DIPHENOXYLATE+FURAZOLIDONE may cause severe bowel problems, especially in patients with ulcerative colitis (inflammation of the colon). So, inform your doctor if you experience bloating, constipation, vomiting, or stomach pain while using this medicine. ATROPINE+DIPHENOXYLATE+FURAZOLIDONE may cause atropine toxicity, so inform your doctor if you notice dizziness, headache, muscle cramps, high fever, decrease in urine volume, painful urination, decrease in the frequency of urination, dry skin, and dry mouth. It should be used with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency as this medicine may cause mild anemia.

Drug Interactions

Drug-Drug Interactions: ATROPINE+DIPHENOXYLATE+FURAZOLIDONE when used along with medicines that affect the central nervous system (brain and spinal cord) may worsen the side-effects. Some examples of medicines that affect CNS are antiallergic medicines (diphenhydramine, cetirizine), sleeping pills (alprazolam), antidepressants (isocarboxazid, tranylcypromine), narcotic pain killers (morphine), and anesthetics, etc. ATROPINE+DIPHENOXYLATE+FURAZOLIDONE may interact with medications used to treat muscle weakness (ambenonium), medicines used to treat alcohol dependence (naltrexone and nalmefene), and medicine used to treat Parkinson’s disease (safinamide).

Drug-Food Interactions: Avoid consumption of foods with high tyramine content such as cheese, yeast, smoked meat, poultry, or fish. Avoid avocado, bitter orange, caffeinated beverages, and alcohol consumption while using this medicine. Avoid taking the above foods at least for 2 weeks after stopping this medicine.

Drug-Disease Interactions: ATROPINE+DIPHENOXYLATE+FURAZOLIDONE should not be used in patients with obstructive jaundice (blockage of bile flow out of liver). It should be used with caution in patients with liver or kidney disease, myasthenia gravis (severe muscle weakness), glaucoma (an eye disease), enlarged prostate, gallbladder problems, difficulty passing urine, blockage or severe inflammation in the intestine or stomach, thyroid problems, and Down’s syndrome (a genetic disorder that causes growth delay in children).

Drug-Drug Interactions Checker List:

  • DIPHENHYDRAMINE
  • CETIRIZINE
  • ALPRAZOLAM
  • ISOCARBOXAZID
  • TRANYLCYPROMINE
  • MORPHINE
  • AMBENONIUM
  • NALTREXONE
  • SAFINAMIDE

    • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Avoid consuming alcohol while taking ATROPINE+DIPHENOXYLATE+FURAZOLIDONE as it may cause increased dizziness or drowsiness.

    • Safety Warning

      Pregnancy

      caution

      ATROPINE+DIPHENOXYLATE+FURAZOLIDONE is a category C medicine. It may cause harmful effects to the unborn baby, so your doctor will prescribe ATROPINE+DIPHENOXYLATE+FURAZOLIDONE only if the benefits outweigh the risks.

    • Safety Warning

      Breast Feeding

      caution

      ATROPINE+DIPHENOXYLATE+FURAZOLIDONE may pass into breastmilk. Consult your doctor before taking ATROPINE+DIPHENOXYLATE+FURAZOLIDONE; your doctor will decide whether ATROPINE+DIPHENOXYLATE+FURAZOLIDONE can be taken by doing a risk-benefit assessment.

    • Safety Warning

      Driving

      caution

      ATROPINE+DIPHENOXYLATE+FURAZOLIDONE may cause dizziness and drowsiness, so do not drive or operate machinery if you feel dizzy or drowsy.

    • Safety Warning

      Liver

      caution

      ATROPINE+DIPHENOXYLATE+FURAZOLIDONE should be used with caution in patients with liver diseases. The dose may have to be adjusted by the doctor as required.

    • Safety Warning

      Kidney

      caution

      ATROPINE+DIPHENOXYLATE+FURAZOLIDONE should be used with caution in patients with liver diseases. The dose may have to be adjusted by the doctor as required.

    • Safety Warning

      Children

      unsafe

      ATROPINE+DIPHENOXYLATE+FURAZOLIDONE should not be given to children below 13 years as safety and effectiveness have not been established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Do not drink or eat many caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. ATROPINE+DIPHENOXYLATE+FURAZOLIDONE may increase nervousness, sleeplessness, and anxiety caused by caffeine. Avoid foods that are rich in tyramine, such as cheese, yeast, poultry, and fish.
    • Probiotics should be taken after taking the full course of ATROPINE+DIPHENOXYLATE+FURAZOLIDONE to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like yogurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine’s good bacteria.
    • Include more fiber-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet. Make sure you drink plenty of water or other fluids every day while you are taking ATROPINE+DIPHENOXYLATE+FURAZOLIDONE.
    • Avoid alcoholic beverages with ATROPINE+DIPHENOXYLATE+FURAZOLIDONE as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the ATROPINE+DIPHENOXYLATE+FURAZOLIDONE in fighting off infections.

    Special Advise

    • Your doctor may check your health condition for the progress and unwanted effects during regular visits.
    • In general, diarrhea improves within 2 days of treatment. However, you should complete the course of therapy to treat the condition completely. If the symptoms don’t improve or worsen after 10 days of treatment, consult your doctor immediately.

    Patients Concern

    Disease/Condition Glossary

    Diarrhoea: It is characterized by loose and watery stools with a frequent need to have a bowel movement. Diarrhoea might be a result of bacterial or parasitic (worm) infection. It can be acute (lasts for a few days) or chronic (lasts for a few weeks). Diarrhoea can lead to loss of water along with salts, electrolytes, and minerals from the body. The common causes of diarrhoea include food intolerance, food allergy, adverse reaction to a medication, or infections. Symptoms include nausea, abdominal pain, cramps, bloating, dehydration, watery loose stools, and frequent urge to evacuate the bowels.

    FAQs

    ATROPINE+DIPHENOXYLATE+FURAZOLIDONE contains Diphenoxylate, Atropine, and Furazolidone. Diphenoxylate works by slowing down the intestinal movements, thereby makes the stools more solid and less frequent. Atropine helps to prevent involuntary muscle movements in the intestine. Atropine is added to prevent the abuse of diphenoxylate as higher doses may cause physical dependence. Furazolidone works by interfering with protein synthesis, a mechanism that is important for the survival of bacteria.

    You may notice an improvement in symptoms within 2 days after taking medicine. However, you should complete the course of therapy as prescribed by the doctor. If you do not notice any improvement in the condition within 10 days after taking ATROPINE+DIPHENOXYLATE+FURAZOLIDONE, talk to your doctor immediately.

    The common side-effects of ATROPINE+DIPHENOXYLATE+FURAZOLIDONE are abdominal discomfort, nausea, vomiting, headache, dry mouth, and dizziness. These side-effects are usually mild and temporary. However, if any of these side-effects persist or get worse, inform your doctor immediately.

    ATROPINE+DIPHENOXYLATE+FURAZOLIDONE may cause dry mouth. So, it is advised to drink plenty of water and take regular sips during the day. It is also necessary to avoid spicy and salty foods as much as possible.

    Avoid taking tyramine-rich foods such as cheese, yeast, smoked meat, poultry, and fish as these foods may interact with ATROPINE+DIPHENOXYLATE+FURAZOLIDONE and cause unwanted effects. In addition, avoid caffeinated beverages and alcohol as these drinks may increase the risk of side-effects.

    ATROPINE+DIPHENOXYLATE+FURAZOLIDONE should be used with caution in elderly people as there is an increased risk of side-effects in this population.

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    ATROPINE+DIPHENOXYLATE+FURAZOLIDONE

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