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Bemcentinib

About

Bemcentinib belongs to the group of immunomodulators. Bemcentinib is used in the treatment of coronavirus disease caused by COVID-19. Coronavirus disease is an infectious disease caused by SARS-CoV-2. It can range from a mild cold to a serious form of pneumonia. It may also use to treat Acute myeloid leukaemia, Non-small cell lung cancer, Melanoma.

Bemcentinib contains ‘’Bemcentinib.’’ Bemcentinib works by inhibiting viral entry into body cells and also prevents the inhibition of a certain type of interferon, which is responsible for the cell’s natural defence mechanism.

Bemcentinib is a prescription-only medication. Bemcentinib is available as a capsule for oral intake. Bemcentinib can be taken with or without food. Bemcentinib should be swallowed whole with a glass of water. Do not crush, chew or break it. Bemcentinib may cause certain common side effects such as fatigue, diarrhoea and loss of appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to Bemcentinib or any of its components. Keep your doctor informed if you suffer from any medical disorders. Keep your doctor informed if you have recently had any surgery or are scheduled for surgery in the near future. Offer a detailed medical and vaccination history. Tell your doctor about your transfusion history and avoid Bemcentinib in case of a recent blood transfusion. Discuss any recent vaccinations with the doctor. Inform the doctor if you are on any drugs that affect the immunity and immune system of the body. Consult your doctor if you are planning to get pregnant or are breastfeeding. Avoid consuming alcohol while using Bemcentinib.

Uses of Bemcentinib

COVID-19, Acute Myeloid Leukaemia, Non-Small Cell Lung Cancer, Melanoma

Medicinal Benefits

Bemcentinib is an immunomodulator used in the treatment of various types of cancers and infections, such as Covid-19. Bemcentinib contains Bemcentinib. Bemcentinib works by inhibiting the entry of the virus into the body cells. Bemcentinib targets a protein receptor called AXL, a common attachment and entry point for most viruses. In addition, Bemcentinib prevents the inhibition of Type-I interferon, which is responsible for the cell’s natural defence mechanism. Bemcentinib also works by blocking the enzyme responsible for catalysing the increase in drug resistance and immune escape, thus helping in maintaining the normal immune function of cells and enhancing drug sensitivity.

Directions for Use

Bemcentinib is a prescription-only medication. Bemcentinib is available as a capsule for oral intake. Bemcentinib can be taken with or without food. Bemcentinib should be swallowed whole with a glass of water. Do not crush, chew or break it. In case you miss a dose of Bemcentinib, take it as soon as you remember. However, if it has been more than 10 hours since you forgot the last dose, move on to the next dose and continue the regimen as usual.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Bemcentinib

  • Fatigue
  • Diarrhoea
  • Increase in liver enzymes
  • Loss of appetite

In-Depth Precautions and Warning

Drug Warnings

It is advisable to inform the doctor if you are allergic to Bemcentinib or any of its components. Keep your doctor informed if you suffer from any brain disorders, nerve cell cancer, meningitis (brain fever), any heart problems such as congestive cardiac failure, heart block, or a family history of sustained QTc syndrome; clinically significant hypokalaemia (low potassium levels), any autoimmune disease such as hypothyroidism, Rheumatoid arthritis, lupus and/or pernicious anaemia; interstitial lung disease, pneumonia, Hepatitis B, abdominal disorders, bowel resection and intestinal disease, psychiatric disorders or a chronic disease such as HIV. Keep your doctor informed if you have recently had any surgery or are scheduled for surgery in the near future. Offer a detailed medical and vaccination history. Tell your doctor about your transfusion history and avoid Bemcentinib in case of a recent blood transfusion. Discuss any recent vaccinations with the doctor. Inform the doctor, especially if you are on any radiotherapy, chemotherapy, other immunomodulators, vitamin K antagonists, antacids, or steroids. Consult your doctor if you are planning to get pregnant or are breastfeeding. Avoid Bemcentinib use with alcohol.

Drug Interactions

Drug-Drug Interactions: Bemcentinib may interact with blood-thinners/anticoagulants (warfarin, acenocoumarol, apixaban, rivaroxaban, heparin). 

Drug-Food Interactions: Bemcentinib may interact with ethanol.

Drug-Disease Interactions: Bemcentinib should be used with caution in patients with a known hypersensitivity disorder, HIV, liver problems, hypokalemia, brain disorders, nerve cell cancer, meningitis (brain fever), any heart problems such as congestive cardiac failure, heart block, or a family history of sustained QTc syndrome; clinically significant hypokalaemia (low potassium levels), any autoimmune disease such as hypothyroidism, Rheumatoid arthritis, lupus and/or pernicious anaemia; interstitial lung disease, pneumonia, Hepatitis B, abdominal disorders, bowel resection and intestinal disease and/or psychiatric disorders.

Drug-Drug Interactions Checker List:

  • WARFARIN
  • ACENOCOUMAROL
  • APIXABAN
  • RIVAROXABAN
  • HEPARIN
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      It is not recommended to consume alcohol while taking Bemcentinib. Please consult your doctor if you have any concerns.

    • Safety Warning

      Pregnancy

      caution

      Not enough studies exist to ascertain the effect of Bemcentinib on pregnancy. Please consult your doctor if you have any concerns.

    • Safety Warning

      Breast Feeding

      caution

      Not enough studies exist to ascertain the effect of Bemcentinib on nursing. Bemcentinib is not recommended to use without contraception during breastfeeding. Please consult your doctor in case of any concerns.

    • Safety Warning

      Driving

      caution

      Bemcentinib may cause fatigue and dizziness. If any side effects hamper your ability to drive, do not drive.

    • Safety Warning

      Liver

      caution

      Exercise caution before using Bemcentinib if you have pre-existing liver disease as it may cause derangement of liver enzymes. Please consult your doctor to address any concerns.

    • Safety Warning

      Kidney

      caution

      Exercise caution before using Bemcentinib if you have pre-existing kidney disease. Please consult your doctor to address any concerns.

    • Safety Warning

      Children

      caution

      Not enough studies exist to ascertain the effect of Bemcentinib in children. Please consult your doctor in case of any concerns.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Keep a healthy state of mind. Fear is one of the biggest causes of decreased immunity. See a therapist if you feel the need. 
    • Meditation, music and yoga have also proven very effective in helping with mental health.
    • Keep yourself at a safe distance from people.
    • Always sneeze or cough into your elbow and keep a handkerchief on you.
    • Wash your hands with soap and water and keep yourself clean.
    • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. Load up on Vitamin-C-rich citrus fruit for enhanced immunity.
    • Do not forget to take your Vitamin B complex and Vitamin C supplements every day, as these are essential for the body and immunity.
    • Steam inhalation for 3-5 minutes every day and salt-water gargling with warm water has been proven very effective in keeping respiratory infections at bay and in promoting health. 
    • Avoid taking Bemcentinib with alcohol as there may be an interaction.
    • Stay hydrated by drinking plenty of water, as dehydration is often seen in pneumonia.
    • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. Doing weight-bearing exercises can prove very helpful in promoting bone health.
    • Avoid tobacco use, as smoking hampers lung health and makes breathing even more difficult.
    • Spend time under the sun (however, with proper sunscreen) for quality intake of Vitamin D. Vitamin D is necessary for the absorption of Calcium, which is the most important component of bones and can help with bone and joint pain.

    Special Advise

    • Discuss contraceptive measures that you are taking with your doctor while using Bemcentinib.
    • Use Bemcentinib with caution in the elderly as they’re more prone to infections. 
    • Bemcentinib is often used in combination with an IV drug. Talk to your doctor for a tailored regimen.

    Patients Concern

    Disease/Condition Glossary

    Coronavirus Disease: Coronavirus disease is an infection caused by the SARS-CoV-2 virus. It can range from a mild cold, cough and fever to full-blown pneumonia. Drop in oxygen saturation and breathlessness was also common symptoms noted. However, the new variant of Omicron is supposed to cause only a mild disease characterised by a scratchy throat and fatigue. 

    Melanoma: Melanoma is a type of skin cancer caused by harmful UV radiation from the sun. It is common in fair-skinned and freckled individuals. It results in mole formation, typically on the skin of the face. 

    Acute Myeloid Leukaemia: Acute myeloid leukaemia is a cancer of the blood cells. It starts in the bone marrow, producing excess immature and defunct white blood cells (WBCs). WBCs help in fighting infection and maintaining the immunity of the body. In the case of immature WBCs, the body’s immune system is heavily compromised. Hence, AML results in increased infections, anaemia, joint pains and aches, dehydration, fatigue, weight loss and unusual bleeding.

    FAQs

    Bemcentinib works by preventing the virus from attaching to the body’s cell receptors, thereby blocking its entry and spread.

    If you suffer from CKD, please consult with your doctor before using Bemcentinib and discuss any concerns with them. Bemcentinib is to be used with caution in those suffering from kidney and liver problems.

    Only an RT-PCR test can determine whether or not you have COVID. While a loss of smell has been noted as a common symptom, the new variant does not cause a loss of smell.

    Not enough literature exists to ascertain the effects of Bemcentinib on fertility. However, Bemcentinib should be avoided in pregnancy unless absolutely warranted. Please consult your doctor in case of any concerns.

    A fibroadenoma is a benign state. Bemcentinib is indicated only in the case of certain types of cancers. You do not need to use Bemcentinib for a fibroadenoma. Please consult your doctor in case of any concerns.

    Your treatment regimen depends entirely on your doctor. While Bemcentinib is highly efficient in mild COVID, it should be used with caution in those with a history of substance abuse.

    Available Medicines for

    Bemcentinib

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