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BEMPEDOIC ACID

About

BEMPEDOIC ACID belongs to a group of medicines called adenosine triphosphate-citrate lyase (ACL) inhibitors used together with lifestyle changes and certain cholesterol-lowering medicines to decrease bad cholesterol in patients with heart disease or familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally).
 
BEMPEDOIC ACID contains Bempedoic acid, which works by blocking an enzyme (ATP citrate lyase) needed for the production of cholesterol. This helps block the production of cholesterol in the liver and increases the removal of LDL cholesterol. Thereby, it helps decrease bad cholesterol in the body.
 
In some cases, BEMPEDOIC ACID may cause side effects such as anaemia, gout, and pain in the shoulders, arms or legs. Most of these side effects may not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Do not take BEMPEDOIC ACID if you are pregnant or breastfeeding. BEMPEDOIC ACID is not recommended for children below 18 years as the safety and effectiveness have not been established. Inform the doctor regarding your health condition and medicines you are taking to rule out any possible side effects/interactions.

Uses of BEMPEDOIC ACID

High cholesterol

Medicinal Benefits

BEMPEDOIC ACID belongs to a group of medicines called adenosine triphosphate-citrate lyase (ACL) inhibitors used in addition to the cholesterol-lowering diet in adult patients with primary hypercholesterolaemia (high cholesterol) or mixed dyslipidaemia (imbalance of lipids), which are conditions that cause a high cholesterol level in the blood. BEMPEDOIC ACID contains Bempedoic acid, which works by blocking an enzyme (ATP citrate lyase) needed for the production of cholesterol. This helps block the production of cholesterol in the liver and increases the removal of LDL cholesterol. Thereby, it helps decrease bad cholesterol in the body.

Directions for Use

Take BEMPEDOIC ACID with food or between meals or as advised by the doctor. Swallow the medicine as a whole with a glass of water; do not chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of BEMPEDOIC ACID

  • Anaemia (low red blood cells)
  • Gout (increased levels of uric acid)
  • Pain in arms, legs, or shoulders
  • Muscle spasms

In-Depth Precautions and Warning

Drug Warnings

Do not take BEMPEDOIC ACID if you are allergic to any of its components, if you are pregnant or breastfeeding. Inform the doctor if you have/had gout, severe kidney or liver problems, or tendon problems. Consult the doctor immediately if you become pregnant during treatment with BEMPEDOIC ACID. Seek medical attention if you experience symptoms of gout (tender joints, joint redness, severe foot pain, especially in the toe joint, warm joints, and swelling), tendon problems (pain, swelling, tears and inflammation of tendons), or tendon rupture (hear or feel a snap or pop in a tendon area, bruising right after an injury in a tendon area, or are unable to move the affected area or put weight on the affected area).

Drug Interactions

Drug-Drug Interactions: Inform the doctor if you are taking statins (atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin), medicine used to treat pulmonary artery hypertension (bosentan), anti-hypertensive (fimasartan), or medicines used to treat hepatitis C (asunaprevir, glecaprevir, grazoprevir, voxilaprevir).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Inform the doctor if you have gout/hyperuricemia (high uric acid levels), tendon problems, or severe kidney or liver problems.

Drug-Drug Interactions Checker List:

  • ATORVASTATIN
  • FLUVASTATIN
  • PITAVASTATIN
  • PRAVASTATIN
  • ROSUVASTATIN
  • SIMVASTATIN
  • BOSENTAN
  • FIMASARTAN
  • GLECAPREVIR
  • GRAZOPREVIR
  • VOXILAPREVIR
  • Safety Advice

    • Safety Warning

      Alcohol

      consult your doctor

      It is not known if alcohol interacts with BEMPEDOIC ACID. Please consult a doctor.

    • Safety Warning

      Pregnancy

      unsafe

      BEMPEDOIC ACID may harm the unborn baby. Do not take BEMPEDOIC ACID if you are pregnant, think you may be pregnant or if you are trying to become pregnant. Consult the doctor immediately if you become pregnant during treatment with BEMPEDOIC ACID.

    • Safety Warning

      Breast Feeding

      unsafe

      It is unknown if Bempedoic acid passes into breast milk. Do not take BEMPEDOIC ACID if you are breastfeeding.

    • Safety Warning

      Driving

      not applicable

      BEMPEDOIC ACID has no or little influence on your ability to drive.

    • Safety Warning

      Liver

      caution

      It is not known if BEMPEDOIC ACID is safe and effective in people with liver disease. Please consult the doctor if you have a liver impairment or any concerns regarding this.

    • Safety Warning

      Kidney

      caution

      It is not known if BEMPEDOIC ACID is safe and effective in people with kidney disease, including end-stage kidney disease, who are on dialysis. Please consult the doctor if you have kidney impairment or any concerns regarding this.

    • Safety Warning

      Children

      unsafe

      BEMPEDOIC ACID is not recommended for children below 18 years as the safety and effectiveness have not been established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Follow a cholesterol-lowering diet.
    • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
    • Limit salt and sugar intake.
    • Avoid smoking and alcohol consumption. 
    • Choose healthy fats and cut down on trans fats.
    • Include omega-3 fatty acids, fibre-rich food, fruits and vegetables.
    • Get active by doing any physical activity such as swimming, brisk walking or jogging. Take stairs instead of elevators/lifts.

    Special Advise

    • Before starting the treatment, you should confirm you are not pregnant. Also, use effective contraception, as advised by your doctor during treatment with BEMPEDOIC ACID.
    • BEMPEDOIC ACID treatment may increase liver enzyme levels. Your doctor may suggest tests to check your liver functioning while on treatment with this medicine.

    Patients Concern

    Disease/Condition Glossary

    High cholesterol: High cholesterol levels in the blood might build up on the walls of the arteries, leading to blockage of blood flow to the heart and other body parts, which could cause heart disease, heart attack or stroke. Cholesterol is mainly of two types, namely, 'bad cholesterol' and 'good cholesterol'. Bad cholesterol comprises low-density lipoprotein (LDL) and triglycerides (TG), which deposit fat in the arteries, leading to their blockage. Good cholesterol consists of high-density lipoprotein (HDL), which prevents the deposition of fats. Risk factors of high cholesterol are high-fat diet, obesity, lack of physical exercise, and smoking.

    FAQs

    BEMPEDOIC ACID works by blocking the production of cholesterol in the liver. Thereby, it helps treat high cholesterol.

    Do not discontinue BEMPEDOIC ACID without consulting your doctor, as it could lead to a rise in cholesterol. To get effective results, continue taking BEMPEDOIC ACID for as long as prescribed. Do not hesitate to speak with your doctor if you experience any difficulty while taking BEMPEDOIC ACID.

    Tendon problems may happen in people taking BEMPEDOIC ACID. Consult the doctor if you experience pain, swelling, inflammation and tears of tendons, including Achilles (back of ankle), arm and shoulder. The risk of tendon problems may be increased if you are above 60 years of age, have renal problems, have had tendon problems or are taking antibiotics or corticosteroids.

    Available Medicines for

    BEMPEDOIC ACID

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