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Benralizumab

About

Benralizumab belongs to the class of 'immunomodulators', primarily used to treat asthma. Asthma is a chronic (long-term) respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty in breathing. Benralizumab is used as an add-on maintenance treatment in severe asthma patients above 12 years of age.

Benralizumab consists of Benralizumab as an active ingredient which belongs to interleukin-5 receptor (IgG1) monoclonal antibody (that serves as a substitute antibody). It works by reducing the synthesis of cytokine, a substance released by the body that initiates an inflammatory response.

Benralizumab may cause common side effects such as fever, itching, headache, sore throat, and breathing difficulty. These side effects resolve over time. Inform your doctor if any of these side effects bother you. Benralizumab will be administered by a healthcare professional. Do not self-administer

Benralizumab should be avoided if allergic to it or any other components present in it. Before starting Benralizumab, inform your doctor if you have any liver or kidney disease or active parasitic infections and are taking any inhaled corticosteroids. Pregnant and breastfeeding mothers should inform the physician before starting treatment with Benralizumab. Benralizumab may cause dizziness, so drive only if you are alert and focused. Avoid consuming alcohol along with Benralizumab as it could lead to increased dizziness. 

Uses of Benralizumab

Asthma

Medicinal Benefits

Benralizumab contains Benralizumab, which is a humanized recombinant IgG1 (Immunoglobulin G1) monoclonal antibody. It works by binding to the IgG1 receptor and reduces the synthesis of cytokine, a substance released by the body that initiates an inflammatory response. Benralizumab is used as a maintenance treatment in asthma patients.

Directions for Use

A trained healthcare professional will administer it. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Benralizumab

  • Upper respiratory tract infection
  • Fever
  • Itching
  • Dizziness
  • Diarrhoea 
  • Headache
  • Sore throat
  • Pain at the site of injection

In-Depth Precautions and Warning

Drug Warnings

To treat your condition effectually, continue taking Benralizumab for the period that your doctor has prescribed. Avoid taking Benralizumab if you are allergic to it or any other components present in it. Inform your doctor if you have any liver or kidney diseases, active parasitic infections, and are taking any inhaled corticosteroids before receiving Benralizumab. Avoid close contact with people who have infections that can be easily spread. Benralizumab may cause dizziness, so drive only if you are alert and focused. Avoid consuming alcohol along with Benralizumab as it could lead to increased dizziness. Benralizumab is not recommended in children below 12 years of age as safety and efficacy are not established. Benralizumab may cause severe allergic reactions and parasitic reactions and reduce the effect of corticosteroid medicines. Hence, inform your doctor about your complete medication and medical history before taking Benralizumab.

Drug Interactions

Drug-Drug Interaction: No interactions found.

Drug-Food Interaction: Avoid alcohol consumption while being treated with Benralizumab. 

Drug-Disease Interaction: Benralizumab should be used with caution in cases of liver or kidney diseases, weak immune systems, and active parasitic infections.

Drug-Drug Interactions Checker List:

Safety Advice

  • Safety Warning

    Alcohol

    caution

    You are recommended to avoid alcohol consumption while taking Benralizumab. Alcohol intake, along with Benralizumab, may cause increased dizziness.

  • Safety Warning

    Pregnancy

    caution

    If you are pregnant or planning pregnancy, inform your doctor before receiving Benralizumab. Your doctor may prescribe this medicine if the benefits outweigh the risks.

  • Safety Warning

    Breast Feeding

    caution

    It is not known if Benralizumab passes into the breastmilk when used by a breastfeeding mother. Your doctor will prescribe Benralizumab only if the benefit outweighs the risk.

  • Safety Warning

    Driving

    unsafe

    Benralizumab may make you feel dizzy. Do not drive or operate machinery until you are completely alert.

  • Safety Warning

    Liver

    caution

    If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine.

  • Safety Warning

    Kidney

    caution

    If you have a pre-existing or a history of kidney problems, tell your doctor before taking this medicine.

  • Safety Warning

    Children

    unsafe

    Benralizumab is not recommended in children below 12 years of age as the safety and efficacy are not established.

Habit Forming

No

Diet & Lifestyle Advise

  • Maintain proper weight by following a healthy and well-balanced diet.
  • Avoid smoking and alcohol consumption.
  • Try to avoid stress by practising meditation or yoga.
  • Try including selenium-rich food sources like Brazil nuts, yellowfin tuna, rice, beans, whole-wheat bread, dairy products, ham, chicken, turkey, beef, eggs, pork, baked beans, mushrooms, oatmeal, and spinach.
  • Include zinc-rich sources like meat, shellfish, legumes, hemp seeds, nuts, eggs, dairy products, whole grains, potatoes, kale, and dark chocolate in your diet.
  • Cut down on sugar, salt and processed foods.
  • Drink plenty of water.

Special Advise

  • The doctor may suggest some tests to know the root cause of the respiratory disorder, such as Spirometry (check the narrowing of bronchial tubes) and Peak flow (check how difficult it is to exhale).
  • Please avoid the use of Tobacco and Marijuana as it decreases the efficacy of Benralizumab. 

Patients Concern

Disease/Condition Glossary

Asthma: It is a chronic (long-term) respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty in breathing. The symptoms of asthma include wheezing (whistling sound while breathing), shortness of breath, chest tightness and cough, especially at night. The treatment for asthma includes medication, breathing exercises and self-care.

FAQs

Benralizumab contains Benralizumab, which reduces the synthesis of pro-inflammatory markers called cytokines. Thus, it helps in decreasing inflammation.

Available Medicines for

Benralizumab

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