Brinzolamide+brimonidine
About
Brinzolamide+brimonidine is indicated for lowering high intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Glaucoma is an eye disease that causes damage to the optic nerve and results in reduced vision. Ocular hypertension is increased pressure in the eye due to poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow).
Brinzolamide+brimonidine is a combination of two drugs, namely: Brinzolamide (carbonic anhydrase inhibitor) and Brimonidine (alpha-2 adrenergic receptor agonist). Brinzolamide+brimonidine decreases the production of aqueous humour, thereby helps lower the increased pressure in the eye.
In some cases, you may experience certain common side effects such as blurred vision, eye redness, discomfort, drowsiness and bad taste in the mouth. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Consult a doctor if you are pregnant or breastfeeding. Brinzolamide+brimonidine is not recommended for children below 18 years as the safety and effectiveness have not been established. Brinzolamide+brimonidine might cause dizziness, drowsiness, and abnormal/blurred vision; so, drive only if you have clear vision. Avoid touching the tip of the dropper as it may contaminate the contents.
Uses of Brinzolamide+brimonidine
Medicinal Benefits
Brinzolamide+brimonidine is a combination of two drugs, namely: Brinzolamide (carbonic anhydrase inhibitors) and Brimonidine (alpha-2 adrenergic receptor agonists). Brinzolamide+brimonidine is indicated for lowering high intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Brinzolamide+brimonidine decreases the production of aqueous humour, thereby helps lower the increased pressure in the eye.
Directions for Use
Storage
Side Effects of Brinzolamide+brimonidine
- Blurred/abnormal vision
- Eye redness
- Eye discomfort
- Drowsiness
- Bad taste in the mouth
- Dry mouth
- Dizziness
- Eye surface inflammation
- Eye pain
In-Depth Precautions and Warning
Drug Warnings
Do not take Brinzolamide+brimonidine if you are allergic to any of its components, if you are taking monoamine oxidase inhibitors, antidepressants, if you have severe kidney problems or excess acidity in the blood. Inform your doctor if you have liver problems, narrow-angle glaucoma, dry eyes, cornea problems, coronary heart disease, depression, poor or disturbed blood circulation. Consult a doctor before using Brinzolamide+brimonidine if you are pregnant or breastfeeding. Brinzolamide+brimonidine is not recommended for children below 18 years as safety and effectiveness have not been established. Brinzolamide+brimonidine might cause dizziness, drowsiness, abnormal/blurred vision; so, drive only if you are alert.
Drug Interactions
Drug-Drug Interactions: Inform your doctor if you are taking digitalis glycoside (digoxin), drugs used to treat glaucoma (acetazolamide, methazolamide, dorzolamide), antipsychotics (chlorpromazine), an alkaloid (reserpine), antidepressants, antiviral, antifungal, anaesthetics, sedatives, opiates, and barbiturates.
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have severe kidney problems, depression, heart problems, or excess acidity in the blood.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid consuming alcohol while using Brinzolamide+brimonidine as it might cause increased dizziness and drowsiness. Please consult your doctor if you have any concerns.
Pregnancy
unsafeBrinzolamide+brimonidine belongs to pregnancy category C. Use effective contraception while using Brinzolamide+brimonidine. Avoid using Brinzolamide+brimonidine during pregnancy unless clearly indicated by the doctor. Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
unsafeBrinzolamide+brimonidine might pass into breastmilk. Avoid breastfeeding while using Brinzolamide+brimonidine.
Driving
unsafeBrinzolamide+brimonidine might cause dizziness, drowsiness, and blurred/abnormal vision. So, avoid driving or operating machinery until your vision is clear.
Liver
cautionPlease consult your doctor if you have any concerns regarding the usage of Brinzolamide+brimonidine in patients with liver impairment.
Kidney
cautionPlease consult your doctor if you have any concerns regarding the usage of Brinzolamide+brimonidine in patients with kidney impairment. Brinzolamide+brimonidine is not recommended for patients with severe kidney disease.
Children
unsafeBrinzolamide+brimonidine is not recommended for children below 18years as the safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Include fresh fruits and vegetables in your diet.
- Avoid smoking and alcohol consumption.
- Avoid intake of baked foods such as cakes, cookies, doughnuts or fried items such as French fries and stick margarine as these foods may worsen glaucoma and damage the optic nerve.
- Cut down your coffee intake as it may increase pressure in the eye. Replace coffee with green tea.
- Avoid exercises such as any position where the head is lower than the body, like an inverted yoga pose, as it may increase pressure in the eye. Doing selective exercises is advised for glaucoma patients.
Patients Concern
Disease/Condition Glossary
Glaucoma: It is an eye condition that causes damage to the optic nerve (essential for good vision) due to abnormally increased pressure in the eye. If it is not treated in time, it may cause blindness. Usually, there are no symptoms for glaucoma initially, except the slow loss of vision gradually. However, some symptoms include visible rainbow-coloured circles around bright lights or blurred vision. Rarely, glaucoma can develop suddenly with intense pain in the eye, visual disturbance or nausea.
Ocular hypertension: It is a condition caused due to poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow). This leads to a build-up of excess fluid in the eye resulting in increased pressure inside the eye without any damage to the optic nerve. If ocular hypertension is not controlled, it may lead to glaucoma.
FAQs
Brinzolamide+brimonidine decreases the production of aqueous humour, thereby helps lower the increased pressure in the eye.
Continue using Brinzolamide+brimonidine for as long as your doctor has prescribed it to you. Consult the doctor if irritation occurs or worsens.
Brinzolamide+brimonidine might cause blurred or abnormal vision. So, avoid driving or operating machinery until your vision is clear to prevent any mishappening.
Do not wear contact lens while using Brinzolamide+brimonidine. Remove contact lenses before using Brinzolamide+brimonidine and put them back 15minutes after using Brinzolamide+brimonidine.
Dry mouth could be a side-effect of Brinzolamide+brimonidine. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol; drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Brinzolamide+brimonidine can be used with other eye medications if prescribed by the doctor. However, maintain a gap of 5-10minutes between Brinzolamide+brimonidine and other eye medications.
