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Casirivimab+imdevimab

About

Casirivimab+imdevimab belongs to the group of monoclonal antibodies used in the post-exposure treatment of mild to moderate respiratory illness caused by COVID-19 in people aged 12 years or older, weighing at least 40kgs. Casirivimab+imdevimab is used in non-hospitalised cases of COVID-19 that are at risk of progressing to severe disease. 

Casirivimab+imdevimab contains Casirivimab and Imdevimab which work by using proteins (monoclonal antibodies) that mimic the natural immune system of the body and fight off the harmful virus. They block the virus attachment and entry into the human cells, thereby preventing the progression of the illness.

A qualified healthcare professional will administer Casirivimab+imdevimab. Do not self-administer. Casirivimab+imdevimab may cause certain common side effects such as redness, pain and soreness at the injection site. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to any of its components. Consult your doctor if you are pregnant, planning to get pregnant or are breastfeeding. Casirivimab+imdevimab is not authorized for use in patients who require oxygen therapy or hospitalisation due to COVID-19.

Uses of Casirivimab+imdevimab

COVID-19

Medicinal Benefits

Casirivimab+imdevimab contains monoclonal antibodies used in the post-exposure treatment of mild to moderate disease caused by SARS-CoV-2. Casirivimab+imdevimab works by using monoclonal proteins to imitate the natural defence mechanism of the body. The COVID virus contains a capsid with spike proteins, through which it penetrates into the body cells to cause infection. Casirivimab+imdevimab binds to the spike protein of the virus. Thereby blocking the spike protein of the virus from attaching to the human receptor cell and arresting the progress of the disease. Hence, Casirivimab+imdevimab finds use in preventing the progression of mild to moderate covid cases to severe cases requiring hospitalisation. Thus, Casirivimab+imdevimab finds use in reducing rates of hospitalisation. Casirivimab+imdevimab may also be used as post-exposure prophylaxis of coronavirus disease in people who are not fully vaccinated against COVID-19, people with immunocompromising conditions, and in those who are at high risk of being exposed to someone with COVID-19.

Directions for Use

Casirivimab+imdevimab will be administered by a qualified healthcare professional. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Casirivimab+imdevimab

  • Redness, soreness and pain at the injection site

In-Depth Precautions and Warning

Drug Warnings

It is advisable to inform the doctor if you are allergic to any of its components. Keep your doctor informed if you suffer from any chronic diseasea such as HIV, asthma, cancer, liver disease, kidney problems, heart disease, neurodevelopmental disorders, sickle cell disease or if you have recently had surgery, gastrostomy, tracheostomy or positive pressure ventilation. Offer a detailed medical and vaccination history. Discuss any recent vaccinations with the doctor. Inform the doctor especially if you are on any radiotherapy, immunosuppressant drugs, blood thinners or any other medicines. Consult your doctor if you are planning to get pregnant or are breastfeeding. Casirivimab+imdevimab is not meant for use as vaccination and in severe hospitalised cases.

Drug Interactions

Drug-Drug Interactions: No interactions found.

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: No interactions found.

Drug-Drug Interactions Checker List:

Safety Advice

  • Safety Warning

    Alcohol

    caution

    It is not recommended to consume alcohol with Casirivimab+imdevimab. Please consult your doctor if you have any concerns.

  • Safety Warning

    Pregnancy

    caution

    Not enough studies exist to ascertain the effect of Casirivimab+imdevimab on pregnancy. Please consult your doctor if you have any concerns.

  • Safety Warning

    Breast Feeding

    caution

    Not enough studies exist to ascertain the effect of Casirivimab+imdevimab on nursing. Please consult your doctor in case of any concerns.

  • Safety Warning

    Driving

    caution

    It is not known if Casirivimab+imdevimab affects your ability to drive. Drive only if you are alert.

  • Safety Warning

    Liver

    caution

    Exercise caution before using Casirivimab+imdevimab in case of established liver disease. Please consult your doctor to address any concerns.

  • Safety Warning

    Kidney

    caution

    Exercise caution before using Casirivimab+imdevimab in case of established kidney disease. Please consult your doctor to address any concerns.

  • Safety Warning

    Children

    caution

    Casirivimab+imdevimab is not recommended for use in children below 12years. Please consult your doctor if you have any concerns.

Habit Forming

No

Diet & Lifestyle Advise

  • Keep a healthy state of mind. Fear is one of the biggest causes of decreased immunity. See a therapist when you feel overwhelmed.
  • Meditation, music and yoga have also proven very effective in helping with mental health.
  • Keep yourself at a safe distance from people.
  • Always sneeze or cough into your elbow and keep a handkerchief on you.
  • Wash your hands with soap and water and keep yourself clean.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. Load up on Vitamin-C rich citrus fruit for enhanced immunity.
  • Do not forget to take your Vitamin B complex and Vitamin C supplements every day as these are essential for the body and immunity.
  • Steam inhalation for 3-5 minutes every day and salt-water gargle with warm water has been proven very effective in keeping respiratory infections at bay and in promoting health. 
  • Stay hydrated by drinking plenty of water as dehydration is often seen in pneumonia.
  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid tobacco use as smoking hampers lung health and makes breathing even more difficult.

Special Advise

  • In case of a fever or rash following Casirivimab+imdevimab, do not use any antipyretic or anti-allergic medicines without consulting the doctor.
  • In case of worsening symptoms such as changes in BP, wheezing, hives, shortness of breath, weakness or confusion, call your doctor immediately.

Patients Concern

Disease/Condition Glossary

Coronavirus Disease: Coronavirus disease is an infection caused by the SARS-CoV-2 virus. It can range from a mild cold, cough and fever to full-blown pneumonia. Coronavirus belongs to a group of RNA viruses and has crown-like projections on the surface of the pathogen. The virus transmits through droplets generated from an infectious person’s cough, sneeze or heavy breathing. The common symptoms of coronavirus disease are dry cough, tiredness, breathlessness, fever, loss of sense of taste and smell, diarrhoea, body pains, headache, and sore throat.

FAQs

Casirivimab+imdevimab works by inducing an antibody response in the body by instilling monoclonal antibodies that mimic the natural defences of the body and block the spike protein of the virus from attaching to body cells, thus arresting the progression of the disease.

Advanced age, obesity, chronic kidney disease, lung disease, sickle cell disease, neurodevelopmental disorders (for example cerebral palsy) and diseases of metabolism are high-risk factors for disease progression.

Not enough literature exists to ascertain the effects of Casirivimab+imdevimab on fertility. Please consult your doctor in case of any concerns.

Covid-19 spreads through respiratory droplets when in close or direct contact with an infected person. The virus can spread through an infected person’s sneeze or cough. The virus can also be transmitted by touching any contaminated surfaces and then touching the nose, mouth or eyes without washing the hands.

Vaccines stimulate the body to make its own antibodies against infection. On the other hand, monoclonal antibodies deliver lab-made antibodies against the virus.

Available Medicines for

Casirivimab+imdevimab

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