Ceftazidime+avibactam
About
Ceftazidime+avibactam belongs to a class of medicines called antibiotics used in the treatment of bacterial infections of the urinary tract, respiratory tract and abdomen. A bacterial infection is a condition in which harmful bacteria grow in the body and cause infection. Bacteremia is the presence of bacteria in the blood.
Ceftazidime+avibactam contains Ceftazidime and Avibactam. Ceftazidime works by interfering with the formation of the bacterial cell wall (a protective covering) that is necessary for their survival. Avibactam decreases bacterial resistance and enhances the activity of Ceftazidime against the bacteria. Together, Ceftazidime+avibactam helps to treat bacterial infections.
In some cases, you may experience redness and swelling at the site of injection, and/or nausea and diarrhoea. Most of these side effects of Ceftazidime+avibactam do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Ceftazidime+avibactam or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, please inform your doctor before taking Ceftazidime+avibactam. Drive only if you are alert as Ceftazidime+avibactam may cause dizziness. Ceftazidime+avibactam should be used with caution in those with renal impairment and Clostridium difficile-associated diarrhoea.
Uses of Ceftazidime+avibactam
Medicinal Benefits
Ceftazidime+avibactam contains Ceftazidime and Avibactam; they act against both aerobic (grow in the presence of oxygen) and anaerobic (grow in the absence of oxygen) gram-negative and gram-positive bacteria. It is used in the treatment of bacterial infections of the urinary tract, respiratory tract, and abdomen. Ceftazidime inhibits enzymes that regulate the formation of the bacterial cell wall, thereby arresting bacterial development. Avibactam is a beta-lactamase inhibitor. Beta-lactamase is an enzyme that inactivates antibiotics and builds up a drug resistance. By inhibiting beta-lactamase, avibactam makes the bacteria more susceptible to antibiotic action. Ceftazidime+avibactam damages the bacterial cell wall, kills bacteria and makes the bacteria more sensitive to the action of the antibiotic. Hence Ceftazidime+avibactam finds widespread use in treating complicated bacterial infections.
Directions for Use
Storage
Side Effects of Ceftazidime+avibactam
- Redness and swelling on injection site
- Diarrhoea
- Dizziness
- Nausea
In-Depth Precautions and Warning
Drug Warnings
If you are allergic to Ceftazidime+avibactam or any other medicines, please tell your doctor. If you have kidney problems or diabetes, inform your doctor before taking Ceftazidime+avibactam. Consult your doctor if you are pregnant or breastfeeding. If you are on a controlled sodium diet, inform your doctor before taking Ceftazidime+avibactam. Ceftazidime+avibactam should not be administered if you are currently on any vaccinations or are scheduled for the same. If you have a widespread rash with peeling skin and blisters, please consult a doctor immediately as these might be signs of Stevens-Johnson syndrome. Drive only if you are alert as Ceftazidime+avibactam may cause dizziness. You are recommended to complete the full course of Ceftazidime+avibactam as prescribed by your doctor for effective results.
Drug Interactions
Drug-Drug Interaction: Ceftazidime+avibactam may interact with gout therapy (probenecid), antibiotics (chloramphenicol, tobramycin, gentamicin) and water tablets (furosemide).
Drug-Food Interaction: No interactions found.
Drug-Disease Interaction: If you have kidney problems or diabetes, inform your doctor before taking Ceftazidime+avibactam.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionThe interaction of Ceftazidime+avibactam with alcohol is unknown. Please consult a doctor before consuming alcohol while using Ceftazidime+avibactam.
Pregnancy
cautionPlease consult a doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionCeftazidime+avibactam may be excreted in human milk in small amounts. Therefore, it is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.
Driving
cautionCeftazidime+avibactam may cause dizziness. Therefore, avoid driving if you feel dizzy after taking Ceftazidime+avibactam.
Liver
cautionTake Ceftazidime+avibactam with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.
Kidney
cautionTake Ceftazidime+avibactam with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Children
cautionCeftazidime+avibactam should be used in children only in doses as prescribed by a doctor. Ceftazidime+avibactam is not recommended for use in children below 3months.
Habit Forming
Diet & Lifestyle Advise
- Take probiotics after completing the full course of Ceftazidime+avibactam to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like cheese, yoghurt, kombucha, sauerkraut and kimchi can help to restore the good bacteria of the intestine.
- Include fibre-rich foods, as they can be easily digested by your gut bacteria, which helps stimulate their growth. Whole grains such as whole-grain bread, brown rice should be included in your diet.
- Make sure you drink plenty of water or other fluids every day while you are taking Ceftazidime+avibactam.
- Avoid alcohol consumption as it may increase adverse effects.
Special Advise
- Regular kidney function tests are recommended, especially in patients with kidney problems while taking Ceftazidime+avibactam so that the dose may be adjusted accordingly.
- If you are about to undergo any blood or urine tests, inform your doctor that you are taking Ceftazidime+avibactam as it may interfere with these tests.
- Ceftazidime+avibactam may interact with certain tests such as glucose (sugar) in urine and coomb’s test (blood test), resulting in unusual results. Therefore, inform the lab technician that you are taking Ceftazidime+avibactam before undergoing any tests.
Patients Concern
Disease/Condition Glossary
Bacterial Infection: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our body. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. It can target any body part and multiply very quickly. When you get infected with bacteria, you can experience generalized symptoms, like fevers, chills, and fatigue.
FAQs
Ceftazidime+avibactam works by damaging the bacterial cell wall (protective covering) that is necessary for their survival and by increasing bacterial sensitivity.
Ceftazidime+avibactam may cause diarrhoea as a common side effect. However, if the condition persists, worsens or if you notice blood or mucus in stools, avoid taking Ceftazidime+avibactam and consult a doctor immediately.
Exercise caution while taking Ceftazidime+avibactam with diuretics/water tablets. You are not advised to take Ceftazidime+avibactam with a diuretic called furosemide as co-administration of these two medicines may increase the risk of kidney problems, especially in patients with kidney impairment and also when Ceftazidime+avibactam is given in high doses. However, please consult your doctor before taking Ceftazidime+avibactam with other medicines.
Ceftazidime+avibactam is not used to treat viral infections. Ceftazidime+avibactam is an antibiotic that is used to treat only bacterial infections.
