Clarithromycin+lansoprazole+tinidazole
About
Clarithromycin+lansoprazole+tinidazole is a combination medicine indicated for the eradication of Helicobacter pylori-associated with peptic ulcer disease. Helicobacter pylori weaken the protective lining of the stomach and intestine; this allows the acid to get through the sensitive lining beneath. Both the bacteria and acid irritate the mucosal lining leading to ulcers. Symptoms include burning sensation in the stomach, frequent burping, bloating, and abdominal pain.
Clarithromycin+lansoprazole+tinidazole contains Clarithromycin, Lansoprazole, and Tinidazole. Clarithromycin kills the bacteria by preventing the synthesis of necessary proteins required for vital bacterial functions. Lansoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for acid production, thereby preventing acid-related ulcers. Tinidazole damages the DNA of bacteria, thereby kills them. Together, Clarithromycin+lansoprazole+tinidazole helps treat peptic ulcer disease.
You are advised to take Clarithromycin+lansoprazole+tinidazole for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, stomach pain, constipation, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Consult your doctor if you are pregnant or breastfeeding. Clarithromycin+lansoprazole+tinidazole may cause drowsiness, so drive only if you are alert. Clarithromycin+lansoprazole+tinidazole is not recommended for children. Avoid consuming alcohol whilst taking Clarithromycin+lansoprazole+tinidazole and for 3 days after discontinuation. On long-term treatment, Clarithromycin+lansoprazole+tinidazole may cause bone fractures, hypomagnesemia (low levels of magnesium), and low levels of vitamin B12.
Uses of Clarithromycin+lansoprazole+tinidazole
Medicinal Benefits
Clarithromycin+lansoprazole+tinidazole is a combination of three drugs, namely: Clarithromycin, Lansoprazole, and Tinidazole. Clarithromycin+lansoprazole+tinidazole is indicated for the eradication of Helicobacter pylori-associated peptic ulcer disease. Clarithromycin is an antibiotic that kills bacteria by preventing the synthesis of necessary proteins required for vital bacterial functions. Lansoprazole is a proton pump inhibitor that works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid, thereby prevents acid-related ulcers. Tinidazole is an antibiotic that damages the DNA of bacteria and infectious microorganisms, thereby kills them. Together, Clarithromycin+lansoprazole+tinidazole helps treat peptic ulcer disease.
Directions for Use
Storage
Side Effects of Clarithromycin+lansoprazole+tinidazole
- Diarrhoea
- Nausea
- Stomach pain
- Constipation
In-Depth Precautions and Warning
Drug Warnings
Do not take Clarithromycin+lansoprazole+tinidazole if you are allergic to any of its contents; if you are taking any proton pump inhibitors, nitroimidazole derivatives, erythromycin or macrolide antibiotics, or rilpivirine; if you have a history of heart problems such as QT prolongation or ventricular cardiac arrhythmia, or if you have both kidney and liver problems. Inform your doctor if you have low magnesium levels, liver or kidney problems. On long-term treatment, Clarithromycin+lansoprazole+tinidazole may cause bone fractures, hypomagnesemia (low levels of magnesium), and low levels of vitamin B12. Consult your doctor if you are pregnant or breastfeeding. Clarithromycin+lansoprazole+tinidazole may cause drowsiness, so drive only if you are alert. Clarithromycin+lansoprazole+tinidazole is not recommended for children. Avoid consuming alcohol whilst taking Clarithromycin+lansoprazole+tinidazole and for 3 days after discontinuation.
Drug Interactions
Drug-Drug Interactions: Clarithromycin+lansoprazole+tinidazole may interact with anti-retroviral (rilpivirine, atazanavir), ergot alkaloid (ergotamine, dihydroergotamine), antacid (cisapride), neuroleptic (pimozide), anti-platelet (cilostazol), anti-gout (colchicine), statin (simvastatin, lovastatin).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have QT prolongation or ventricular cardiac arrhythmia, kidney and liver problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Clarithromycin+lansoprazole+tinidazole and for 3 days after discontinuation as it might cause abdominal pain, vomiting, nausea, flushing, and headache.
Pregnancy
cautionConsult your doctor if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
unsafeClarithromycin+lansoprazole+tinidazole contains tinidazole; therefore, breastfeeding should be avoided during treatment and for 72 hours following administration. Consult your doctor if you have any concerns.
Driving
cautionClarithromycin+lansoprazole+tinidazole may cause drowsiness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor if you have kidney impairment or any concerns regarding this.
Children
unsafeClarithromycin+lansoprazole+tinidazole is not recommended for children.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating to prevent acid reflux.
- Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
- Practise relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously, as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.
Patients Concern
Disease/Condition Glossary
Helicobacter pylori infection: Helicobacter pylori is a type of bacteria that weakens the protective lining of the stomach and intestine; this allows the acid to get through the sensitive lining beneath. Both the bacteria and acid irritate the mucosal lining leading to ulcers. In most cases, people having peptic ulcers also have H.pylori in their stomachs. If the bacteria are killed, it is unlikely that the ulcer will come back. Symptoms include burning sensation in the stomach, frequent burping, bloating, nausea, and abdominal pain.
FAQs
Clarithromycin+lansoprazole+tinidazole contains Clarithromycin, Lansoprazole, and Tinidazole. Clarithromycin and tinidazole kill the bacteria by interfering with their functioning. Lansoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid, thereby prevents acid-related ulcers. Together, Clarithromycin+lansoprazole+tinidazole helps treat ulcers.
Diarrhoea might be a side-effect of Clarithromycin+lansoprazole+tinidazole. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you have watery stools and stomach pain.
Clarithromycin+lansoprazole+tinidazole contains lansoprazole which might increase the risk of bone fracture in the hip, spine or wrist. This mainly occurs in people taking higher doses/multiple doses of Clarithromycin+lansoprazole+tinidazole for longer durations. Inform your doctor before taking Clarithromycin+lansoprazole+tinidazole if you have osteoporosis.
To treat your condition effectually, continue taking Clarithromycin+lansoprazole+tinidazole for as long as your doctor has advised. Do not be reluctant to speak with your doctor if you experience any difficulty whilst taking Clarithromycin+lansoprazole+tinidazole.
Avoid taking Clarithromycin+lansoprazole+tinidazole if you have a history of heart conditions such as ventricular cardiac arrhythmia or QT prolongation. Talk to your doctor if you have any concerns.
