COBICISTAT

Please do not take COBICISTAT if you are allergic to COBICISTAT or any of its ingredients without discussing the healthcare professional. Please seek medical advice from the doctor before taking COBICISTAT if you are pregnant or breastfeeding. Your doctor will prescribe only if the benefits outweigh the risks. COBICISTAT causes weakness, and headache, so drives only if you are alert. COBICISTAT should not be given to children and adulterants as safety and effectiveness have not been established. Avoid consuming alcohol along with COBICISTAT as it could lead to undesirable effects. Keep your doctor informed about all your health conditions and the medicines you are using to rule out any side effects. Do not begin a new medication without first consulting your healthcare provider. Your healthcare provider can advise you on whether it is safe to combine COBICISTAT with atazanavir or darunavir, as well as other medications. Co-administration of COBICISTAT with ritonavir-containing medications or regimens is not recommended.

Drug-Drug Interactions: COBICISTAT may interact with similar category anti-viral medications (e.g. ritonavir, emtricitabine/tenofovir), medicines used to treat fungal infections (e.g. ketoconazole, itraconazole, voriconazole, posaconazole and fluconazole), medicines used to treat bacterial infections including tuberculosis (e.g. clarithromycin and rifabutin), medicines used to treat cancer (e.g. dasatinib, nilotinib, vinblastine), corticosteroids (e.g. betamethasone, budesonide, fluticasone), and medicines used to lower cholesterol (e.g. atorvastatin, fluvastatin), and medicine used to relieve red, itchy, watery eyes, sneezing (e.g. chlorpheniramine).

Drug-Food Interactions: It is not suggested to consume alcohol while using COBICISTAT since it may cause unpleasant side effects or make you more susceptible to the effects of alcohol.

Drug-Disease Interactions: Inform your doctor before taking COBICISTAT if you have renal dysfunction.

• Remember always to wear a mask when you're around other people. Wearing a mask aids in the prevention of illness spread.
• Take care of your mental health. Fear and anxiety can hamper the immune system as well. Therapy, yoga, and meditation effectively allow the mind a state of peace.
• Keep a social distance and avoid social gatherings.
• Do not touch your eyes, nose or mouth if your hands are not clean.
• Hands should be washed with soap and water or an alcohol-based sanitiser on a regular basis.
• Surfaces should be cleaned and disinfected on a regular basis.
• Gargling with salt water and inhaling steam would be beneficial.
• Never exchange personal objects that have been contaminated with bodily fluids or blood, such as razor blades or toothbrushes.
• Never share used needles and other injection or drug equipment, as it may spread viruses.
• Consume a well-balanced diet. Consume vitamin and nutrient-rich foods like dark green, yellow, orange, and red vegetables and fruits to enhance your immune system. Choose lean protein and whole carbohydrates over-processed foods.
• Consume no raw meat or eggs. Consume boiled and cooked meat, poultry, or seafood.
• If you have nausea or vomiting, eat bland, low-fat foods and avoid spicy or greasy foods.
• Spending time with family or doing whatever makes you happy might help you minimise emotional and physical stress.

• Assess estimated creatinine clearance prior to commencing COBICISTAT since COBICISTAT reduces estimated creatinine clearance by inhibiting creatinine tubular secretion without changing actual renal glomerular function.
• Assess estimated creatinine clearance, urine glucose, and urine protein at baseline when co-administering COBICISTAT with tenofovir disoproxil fumarate.