Glucosamine+diacerein+methylsulfonylmethane
About
Diacerein+glucosamine+methylsulfonylmethane belongs to a group of medications known as 'supplements & adjuvant therapy' used to reduce the pain of osteoarthritis (OA) in specific large and small joints. Osteoarthritis is a chronic (lifelong) joint condition in which Glucosamine sulfate (a chemical found in the human body, especially in joints) gets reduced. The body uses this fluid to produce other chemicals required to make ligaments, cartilage, tendons and the thick fluid surrounding joints. When this chemical get reduces, then the cartilage breaks down and becomes thin which causes friction between the bones leading to wear and tear (damage) of the joint tissues leading to pain, stiffness, inflammation, and reduced locomotion.
Diacerein+glucosamine+methylsulfonylmethane compromises three medicines, namely Glucosamine, Diacerein and Methylsulfonylmethane. Taking Glucosamine may either enhance the cartilage and fluid surrounding joints or prevent both component's breakdown. At the same time, Diacerein restricts the action of a protein responsible for causing inflammation and destruction of cartilage or osteoarthritis. Methylsulfonylmethane (MSM) reduces joint pain, lowers inflammation, improves skin health, reduces allergic symptoms, and increases recovery after exercise. All in combination helps in the formation of cartilage (the soft tissue that cushions the joints) and make the joints lubricated for better movement and flexibility. Diacerein+glucosamine+methylsulfonylmethane relieves pain, thereby improving joint functioning and helping an individual restore his/her quality of life. It also increases the cushioning and lubrication of joints providing relief from pain and easily do physical activity.
Take Diacerein+glucosamine+methylsulfonylmethane as prescribed by your doctor. You are suggested to take Diacerein+glucosamine+methylsulfonylmethane as long as your doctor has prescribed it after checking your medical condition. In some cases, you may experience certain common side effects such as headache, tiredness, nausea, abdominal pain, indigestion, diarrhea, constipation and wind. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these undesirable effects persistently.
Diacerein+glucosamine+methylsulfonylmethane is not allowed to use in children younger than 18 years old. Consult with your doctor if you have ever had blood clots or circulation problems in your legs or if you are pregnant or planning to be pregnant as this may harm an unborn baby. Tell your doctor if you are breastfeeding as It may not be safe to breastfeed a baby while taking Diacerein+glucosamine+methylsulfonylmethane.
Uses of Glucosamine+diacerein+methylsulfonylmethane
Medicinal Benefits
Diacerein+glucosamine+methylsulfonylmethane compromises three medicines, namely Glucosamine, Diacerein, and Methylsulfonylmethane. Glucosamine sulfate is a natural protein used by the body to produce various chemicals responsible for building ligaments, cartilage, tendons and the thick fluid surrounding joints. When an individual becomes old, the levels of this fluid start reducing, which leads to a slow breakdown of joints. Taking it as a supplement boosts joint health and eases pain related to osteoarthritis. Diacerein is a slowly-acting medication that effectively treats swelling and pain in the joints. Methylsulfonylmethane is a type of natural chemical found in animals, plants and humans. Taking it as a supplement helps reduce inflammation, lowers pain and speeds recovery after exercise. It also reduces joint degeneration, which is a common reason for pain in the back, hands, knees and hips. All three medicines in combination, relieve pain or swelling due to Osteoarthritis.
Directions for Use
Storage
Side Effects of Glucosamine+diacerein+methylsulfonylmethane
- Nausea
- Diarrhoea
- Headache
- Tiredness
- Indigestion
- Constipation
- Abdominal pain
- Discoloration of urine
In-Depth Precautions and Warning
Drug Warnings
People with joint infection or skin disease in the affected area should consult a doctor before taking Diacerein+glucosamine+methylsulfonylmethane. People dealing with impaired glucose tolerance, kidney or liver dysfunction risk factors for heart (cardiovascular) disease and who have asthma should take Diacerein+glucosamine+methylsulfonylmethane with caution. Consumption of alcohol should be avoided during the treatment with Diacerein+glucosamine+methylsulfonylmethane as it may lead to increased risk of liver damage. Patients with blood clots or circulation problems in their legs should not take Diacerein+glucosamine+methylsulfonylmethane. Although Diacerein+glucosamine+methylsulfonylmethane provides symptomatic relief in conditions like arthritis and may reduce the inflammation caused by these conditions, to achieve the best results, it is strongly recommended to remain physically active as much as your condition allows. Adopting a healthy lifestyle coupled with a healthy diet containing high proteins is the mainstay of managing arthritic conditions.
Drug Interactions
Drug-Drug Interactions: Diacerein+glucosamine+methylsulfonylmethane can interact with medicines used for blood thinning (Warfarin), medications for cancer (Paclitaxel), painkillers (Acetaminophen), antidiabetes drugs (glimepiride, pioglitazone). Inform your doctor if you are using any of these.
Drug-Food Interactions: Avoid intake of Vitamin E, St. John’s wort (antidepressant) and Ginkgo Biloba with Diacerein+glucosamine+methylsulfonylmethane.
Drug-Disease Interactions: People dealing with impaired glucose tolerance, kidney or liver dysfunction risk factor for heart (cardiovascular) disease, suffer from asthma should take Diacerein+glucosamine+methylsulfonylmethane with caution.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionYou are recommended not to consume alcohol along with Diacerein+glucosamine+methylsulfonylmethane to avoid unpleasant side-effects.
Pregnancy
cautionDiacerein+glucosamine+methylsulfonylmethane should not be taken in pregnancy as the safety and effectiveness of Diacerein+glucosamine+methylsulfonylmethane has not been established. Your doctor will weigh the benefits and any potential risks before prescribing it to you.
Breast Feeding
cautionNot enough scientific data available for Diacerein+glucosamine+methylsulfonylmethane, hence it is best to consult a doctor.
Driving
cautionIn some cases, Diacerein+glucosamine+methylsulfonylmethane may cause dizziness and drowsiness. So if you observe such symptoms, then do not drive.
Liver
cautionDiacerein+glucosamine+methylsulfonylmethane should be used with caution in persons dealing with any liver disorders. Your doctor will weigh the benefits and any potential risks before prescribing it to you.
Kidney
cautionDiacerein+glucosamine+methylsulfonylmethane should be used with caution in persons dealing with any kidney disorders. Your doctor will weigh the benefits and any potential risks before prescribing it to you.
Children
unsafeDiacerein+glucosamine+methylsulfonylmethane can not be given to persons younger than 18 years of age as safety and effectiveness of Diacerein+glucosamine+methylsulfonylmethane has not been established.
Habit Forming
Diet & Lifestyle Advise
- Include more glucosamine, chondroitin sulfate, vitamin D, calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.
- Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on a treadmill, bike riding and swimming. You can also strengthen your muscle strength by lifting light weights.
- In the chronic condition of arthritis or joint pain, including fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.
- Your sitting posture is important, especially when have pain and inflammation condition. Try to sit little as possible, and only for a short time (10-15 min). Use back support like a rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.
Special Advise
- X- rays of affected joints is done to identify osteoarthritis
- Diacerein+glucosamine+methylsulfonylmethane may take several weeks/months to show any improvement, if there is no improvement after using Diacerein+glucosamine+methylsulfonylmethane for 2-3 months.
Patients Concern
Disease/Condition Glossary
Pain: It is an unpleasant sensation and emotional experience that is associated with tissue damage. It allows the body to react and prevent further tissue damage. Pain can be short-term (acute) or long-term (chronic). Perception of pain can differ from person to person where from tolerable to non-tolerable.
Osteoarthritis: Osteoarthritis is a chronic (lifelong) joint condition in which the Glucosamine sulfate (a chemical found in the human body, especially in joints) gets reduced. The body uses this fluid to produce other chemicals required to make ligaments, cartilage, tendons and the thick fluid surrounding joints. When this chemical get reduces, then the cartilage breaks down and becomes thin which causes friction between the bones leading to wear and tear (damage) of the joint tissues leading to pain, stiffness, inflammation, and reduced locomotion. It causes the bone to rub together, leading to pain, stiffness and other osteoarthritis symptoms. This disease can occur in any joint but commonly affected areas of the body are hands, fingertips, knees, hips, spine, typically at the neck or lower back. The most common osteoarthritis symptoms include pain, tenderness (discomfort when pressing on the area with fingers), stiffness and inflammation.
FAQs
Diacerein+glucosamine+methylsulfonylmethane is not suggested in patients having liver problems. Diacerein+glucosamine+methylsulfonylmethane is also not administered to patients with known allergy to Diacerein+glucosamine+methylsulfonylmethane.
The safety and effectiveness of Diacerein+glucosamine+methylsulfonylmethane in joints other than the knee have not been established. Consult your doctor for further advice.
Glucosamine sulfate is a natural protein found in the body used by the body to produce various chemicals responsible for building ligaments, cartilage, tendons and the thick fluid surrounding joints. Taking Diacerein+glucosamine+methylsulfonylmethane may either enhance the cartilage and fluid surrounding joints or prevent both component's breakdown.
You are advised to tell your doctor if you have diabetes, high cholesterol or triglycerides (a type of fat in the blood), cancer, liver disease, asthma or other breathing disorder if you are allergic to shellfish or you have taken a blood thinner (warfarin, Coumadin, Jantoven).
Some research suggests that the presence of Glucosamine in Diacerein+glucosamine+methylsulfonylmethane may affect antidiabetic drugs, it can also increase the blood sugar level in type 2 diabetes. This is why it is suggested to go for regular checkup of blood sugar with type 2 diabetes.
Diacerein+glucosamine+methylsulfonylmethane may increase the risk of bleeding in people taking Warfarin, so it is advised to tell your doctor if you are taking Warfarin or any other medicine.
Some research suggests that glucosamine sulfate may enhance insulin levels in the body which can increase blood pressure. To be safer side, go for regular blood checks and closely monitor your blood pressure.
It has been noticed that Diacerein+glucosamine+methylsulfonylmethane may cause allergic reactions in persons who are sensitive to shellfish. Glucosamine is produced synthetically from shells of shrimp, lobster and crabs.
Some research suggests that Diacerein+glucosamine+methylsulfonylmethane may rarely increase pressure inside the eye and may worsen glaucoma. So if you have glaucoma then inform your doctor before using Diacerein+glucosamine+methylsulfonylmethane.
