Domperidone+flunarizine+paracetamol
About
Domperidone+flunarizine+paracetamol is a combination medicine used for the symptomatic treatment of migraine, and any medical condition with concomitant nausea/vomiting and fever/pain. Migraine is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head, eyes, face, and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.
Domperidone+flunarizine+paracetamol is a combination of three drugs, namely: Domperidone, flunarizine, and Paracetamol. Domperidone prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Flunarizine is a calcium channel blocker that works by preventing the narrowing of blood vessels in the head thereby preventing migraine headache. Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain.
Your doctor will recommend how often you take Domperidone+flunarizine+paracetamol based on your medical condition. Some people may experience some side effects like weight gain, drowsiness, dryness in the mouth. Most of these side effects of Domperidone+flunarizine+paracetamol do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
You can increase the efficacy of Domperidone+flunarizine+paracetamol by taking a small meal or snacks frequently. Do not take Domperidone+flunarizine+paracetamol if you are allergic to Domperidone+flunarizine+paracetamol and other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Domperidone+flunarizine+paracetamol. Inform your doctor if you have heart, kidney, and liver disease. Prolonged intake of Domperidone+flunarizine+paracetamol may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Domperidone+flunarizine+paracetamol, immediately contact your doctor. Domperidone+flunarizine+paracetamol is not recommended n depression, Parkinson's disease, or breast cancer.
Uses of Domperidone+flunarizine+paracetamol
Medicinal Benefits
Domperidone+flunarizine+paracetamol is a combination of three drugs, namely: Domperidone, flunarizine, and Paracetamol belong to the class anti-migraine agents used for the treatment of migraine. Domperidone prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Flunarizine is a calcium channel blocker that works by preventing the narrowing of blood vessels in the head thereby preventing migraine headache. Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain.
Directions for Use
Storage
Side Effects of Domperidone+flunarizine+paracetamol
- Weight gain
- Drowsiness
- Dryness in mouth
In-Depth Precautions and Warning
Drug Warnings
You can increase the efficacy of Domperidone+flunarizine+paracetamol by taking a small meal or snacks frequently. Do not take Domperidone+flunarizine+paracetamol if you are allergic to Domperidone+flunarizine+paracetamol and other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Domperidone+flunarizine+paracetamol. Inform your doctor if you have heart, kidney, and liver disease. Prolonged intake of Domperidone+flunarizine+paracetamol may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. Domperidone+flunarizine+paracetamol is not recommended in depression, shock, phenylketonuria, Parkinson's disease, breast cancer. Prolonged intake of Domperidone+flunarizine+paracetamol may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack), urinary tract obstruction. This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose.
Drug Interactions
Drug-Drug Interaction: Domperidone+flunarizine+paracetamol interact with medicines used to treat heart problems (amiodarone, amlodipine, dronedarone, quinidine, sotalol, diltiazem, verapamil), antibiotics (erythromycin, clarithromycin, moxifloxacin), gastrointestinal disorder (cisapride, dolasetron), blood thinners (warfarin), vomiting and nausea related pills (metoclopramide) and bile related medicines (cholestyramine), anti-epileptics (carbamazepine), estrogens (Ethinyl estradiol)
Drug-Food Interaction: Domperidone+flunarizine+paracetamol may interact with alcohol.
Drug-Disease interaction: The use of Domperidone+flunarizine+paracetamol is restricted in people with liver disease, a history of gastrointestinal bleeding, or any problem involving the bowels, depression, Parkinson's disease, shock, phenylketonuria, breast cancer.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAlcohol may increase the risk of tiredness and drowsiness with Domperidone+flunarizine+paracetamol. If you do feel tired or drowsy whilst taking Domperidone+flunarizine+paracetamol, avoid alcoholic drinks
Pregnancy
unsafeDomperidone+flunarizine+paracetamol is not recommended during pregnancy. Consult your doctor before taking Domperidone+flunarizine+paracetamol.
Breast Feeding
unsafeDomperidone+flunarizine+paracetamol is not recommended during breastfeeding. Consult your doctor before taking Domperidone+flunarizine+paracetamol.
Driving
unsafeTaking Domperidone+flunarizine+paracetamol may cause dizziness, drowsiness, tiredness, or any visual disturbances; you must not drive or use machinery.
Liver
cautionDomperidone+flunarizine+paracetamol is to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
Kidney
cautionDomperidone+flunarizine+paracetamol is to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.
Children
safe if prescribedGenerally, Domperidone+flunarizine+paracetamol is not recommended for children below 12 years with or without a doctor's consent. In case it has to be given, then the dose has to be adjusted and recommended by a child specialist only.
Habit Forming
Diet & Lifestyle Advise
- Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating overly- sweet food and include more salty food, especially if you have been vomiting.
- Also, if you like vomiting at a specific time, avoid eating your favourite food at that particular time as your taste for that food may get turned off.
- Include more cool beverages in your food like clear soup, flavoured gelatin, carbonated beverages. Also, when you drink with a stray, sip slowly to avoid swallowing air that may lead to gas and acidity.
- Drink after or any other liquid at least 30 minutes after eating food.
- Avoid smoking and alcohol intake.
- Avoid chronic stress as it can raise your migraine pain. Try to enjoy and spending time with your friends to cope with stress and practice mindfulness techniques.
Special Advise
- Do not use this Domperidone+flunarizine+paracetamol if your suffering current depressive illness or with a history of recurrent depression, let your doctor know about it.
- A Prolonged intake of Domperidone+flunarizine+paracetamol can increase the risk of cardiac arrhythmia (irregular heartbeat), so close monitoring of heartbeat is required.
Patients Concern
Disease/Condition Glossary
Migraine: Migraine is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head. People may experience migraine pain in the eyes face and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound. Migraine attacks can last for hours to days, and the pain and symptoms can be so severe that it interferes with your daily activities.
FAQs
Domperidone+flunarizine+paracetamol is a combination of three drugs, namely: Domperidone, flunarizine, and Paracetamol. Domperidone prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Flunarizine is a calcium channel blocker that works by preventing the narrowing of blood vessels in the head thereby preventing migraine headache. Paracetamol is an analgesic (pain reliever) and antipyretic (fever reducer). It blocks the release of certain chemical messengers in the brain that are responsible for pain.
Some people may experience common side effects like weight gain, drowsiness, dryness in the mouth. Most of these side effects of Domperidone+flunarizine+paracetamol do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Talk to your doctor if you do not feel better even after taking Domperidone+flunarizine+paracetamol for 14 days. Do not take Domperidone+flunarizine+paracetamol for longer durations unless prescribed by the doctor.
It is best to avoid alcohol while taking Domperidone+flunarizine+paracetamol as it can make damage to your liver.
Yes, Domperidone+flunarizine+paracetamol is known to cause weight gain. So, do regular exercise and try to eat home-cooked food to avoid excessive weight gain.