Domperidone+ranitidine
About
Domperidone+ranitidine belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.
Domperidone+ranitidine is a combination of two drugs, namely: Ranitidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Ranitidine works by blocking histamine H2 receptors located on the stomach lining, thereby reducing gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscles. Together, Domperidone+ranitidine helps in treating acidity.
You are advised to take Domperidone+ranitidine for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dry mouth, stomach pain, constipation, headache, sleepiness, and dizziness. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Consult your doctor if you are pregnant or breastfeeding. Domperidone+ranitidine may cause sleepiness and dizziness, so drive only if you are alert. Domperidone+ranitidine should not be given to children as safety has not been established. Avoid consuming alcohol along with Domperidone+ranitidine as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side-effects.
Uses of Domperidone+ranitidine
Medicinal Benefits
Domperidone+ranitidine belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. Domperidone+ranitidine is a combination of two drugs, namely: Ranitidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Ranitidine works by blocking histamine H2 receptors located on the stomach lining, thereby reduces gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscle. Together, Domperidone+ranitidine helps in treating acidity.
Directions for Use
Storage
Side Effects of Domperidone+ranitidine
- Dry mouth
- Stomach pain
- Constipation
- Headache
- Sleepiness
- Dizziness
In-Depth Precautions and Warning
Drug Warnings
Do not take Domperidone+ranitidine if you are allergic to any of its contents. Inform your doctor before taking Domperidone+ranitidine if you have a history of gastrointestinal bleeding, porphyria, or intestinal obstruction. Domperidone+ranitidine may cause B12 deficiency in long-term treatment. Consult your doctor if you are pregnant or breastfeeding. Domperidone+ranitidine may cause sleepiness and dizziness, so drive only if you are alert. Domperidone+ranitidine should not be given to children as safety has not been established. Avoid consuming alcohol along with Domperidone+ranitidine as it could lead to increased drowsiness and can elevate the production of stomach acid.
Drug Interactions
Drug-Drug Interactions: Domperidone+ranitidine may have interaction with pain killers (acetaminophen, ibuprofen, aspirin, naproxen, methadone), an antidepressant (duloxetine, citalopram, escitalopram), vitamin (vitamin b12), anti-fungal (ketoconazole, fluconazole, voriconazole), antibiotics (erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine), heart-related medicines (propranolol, procainamide, amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol, diltiazem, verapamil), antipsychotics (haloperidol, pimozide, sertindole), gastrointestinal drugs (cisapride, dolasetron), antihistamine (mequitazine, mizolastine), anti-malarial (halofantrine), a protease inhibitor (telaprevir), anti-cancer (toremifene, vandetanib, vincamine), anti-muscarinic (diphemanil), anti-anxiety (diazepam), anticonvulsant (phenytoin), anti-asthma (theophylline), blood thinner (warfarin), antidiabetic (glipizide).
Drug-Food Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Drug-Disease Interactions: Inform your doctor if you have gastrointestinal bleeding, porphyria, haemodialysis, phenylketonuria, liver and kidney dysfunction.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Domperidone+ranitidine. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Pregnancy
cautionConsult your doctor before taking Domperidone+ranitidine if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor before taking Domperidone+ranitidine; your doctor will decide whether Domperidone+ranitidine can be taken by breastfeeding mothers or not.
Driving
cautionDomperidone+ranitidine may cause dizziness and sleepiness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor before taking Domperidone+ranitidine if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Domperidone+ranitidine if you have kidney impairment or any concerns regarding this.
Children
unsafeDomperidone+ranitidine should not be given to children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating.
- Avoid tight-fitting clothes.
- Maintain a healthy weight by regular exercising.
- Practise relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.
Patients Concern
Disease/Condition Glossary
Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers: Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
FAQs
Domperidone+ranitidine is a combination of two drugs, namely: Ranitidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Ranitidine works by blocking histamine H2 receptors located on the stomach lining, thereby reduces gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscle. Together, Domperidone+ranitidine helps in treating acidity.
Talk to your doctor if you do not feel better even after taking Domperidone+ranitidine for 7 days. Do not take Domperidone+ranitidine for longer durations unless prescribed by the doctor.
Constipation might be a side-effect of Domperidone+ranitidine. Drink enough fluids and eat fibre rich food if you experience constipation.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Dry mouth could be a side-effect of Domperidone+ranitidine. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Domperidone+ranitidine contains domperidone which helps in treating nausea and vomiting. However, Domperidone+ranitidine is used to treat acidity. Please consult your doctor, he/she may prescribe you an alternate medicine for treating nausea and vomiting.
