Doxylamine Succinate+pyridoxal 5 Phosphate
About
Doxylamine Succinate+pyridoxal 5 Phosphate belongs to the class of medications called “anti-emetics” primarily used to treat nausea and vomiting during pregnancy. It helps treat morning sickness (nauseous feeling during the first trimester) in pregnant women. Nausea is an uneasy feeling in which a person feels an urge to vomit, while vomiting is the body's natural response to discharge the stomach content forcefully.
Doxylamine Succinate+pyridoxal 5 Phosphate is a combination of two drugs, namely: Doxylamine succinate and Pyridoxal-5-phosphate (vitamin B6). Doxylamine succinate belongs to the class of antihistamines that works by blocking the natural chemical (histamine) in the body, thereby preventing nausea and vomiting. Pyridoxine/vitamin B6 deficiency may cause nausea and vomiting during pregnancy. Pyridoxal-5-phosphate works by increasing the level of vitamin B6 in the body and thus treating nausea and vomiting during pregnancy.
You are advised to take Doxylamine Succinate+pyridoxal 5 Phosphate for as long as your doctor has prescribed it, depending on your medical condition. In some cases, you may experience certain common side effects, such as dizziness, stomach pain, constipation, and dry mouth. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
If you are allergic to Doxylamine Succinate+pyridoxal 5 Phosphate or any other medicines, please tell your doctor. Consult your doctor before taking Doxylamine Succinate+pyridoxal 5 Phosphate if you are pregnant, planning for pregnancy, or breastfeeding. Doxylamine Succinate+pyridoxal 5 Phosphate may make you dizzy or drowsy, hence avoid driving if you are not alert. Avoid consuming alcohol along with Doxylamine Succinate+pyridoxal 5 Phosphate as it could lead to increased drowsiness. Doxylamine Succinate+pyridoxal 5 Phosphate should not be given to anyone below 18 years of age as the safety and efficacy have not been established.
Uses of Doxylamine Succinate+pyridoxal 5 Phosphate
Medicinal Benefits
Doxylamine Succinate+pyridoxal 5 Phosphate contains Doxylamine succinate and Pyridoxal-5-phosphate (vitamin B6). It is used to treat nausea and vomiting during pregnancy. Doxylamine succinate belongs to the class of antihistamines that works by blocking the natural chemical (histamine) in the body, thereby preventing nausea and vomiting. Pyridoxine/Vitamin B6 deficiency may cause nausea and vomiting during pregnancy. Pyridoxal-5-phosphate works by increasing the level of vitamin B6 in the body and treats nausea and vomiting during pregnancy.
Directions for Use
Storage
Side Effects of Doxylamine Succinate+pyridoxal 5 Phosphate
- Dizziness
- Stomach pain
- Constipation
- Dry mouth
In-Depth Precautions and Warning
Drug Warnings
Do not take Doxylamine Succinate+pyridoxal 5 Phosphate if you are allergic to any of its contents. Tell your doctor if you have a medical history of asthma, glaucoma, stomach ulcer, or a blockage in your gut (digestive tract), liver, and kidney problems before starting Doxylamine Succinate+pyridoxal 5 Phosphate. Please consult your doctor if you are pregnant or breastfeeding before taking Doxylamine Succinate+pyridoxal 5 Phosphate. Drive only if you are alert as Doxylamine Succinate+pyridoxal 5 Phosphate may make you feel dizzy. Avoid consuming alcohol along with Doxylamine Succinate+pyridoxal 5 Phosphate as it could lead to increased dizziness. Doxylamine Succinate+pyridoxal 5 Phosphate is not recommended in children below 18 years of age.
Drug Interactions
Drug-Drug Interaction: Doxylamine Succinate+pyridoxal 5 Phosphate may interact with monoamine oxidase inhibitors (MAOIs) (selegiline, isocarboxazid, phenelzine), anti-anxiety medications (alprazolam, chlordiazepoxide), sedative-hypnotics (lorazepam), and other antihistamine drugs (diphenhydramine, chlorpheniramine).
Drug-Food Interaction: You are recommended to avoid alcohol consumption while taking Doxylamine Succinate+pyridoxal 5 Phosphate since it could lead to increased dizziness and drowsiness.
Drug-Disease Interaction: Doxylamine Succinate+pyridoxal 5 Phosphate should be cautiously used in patients with depression, asthma/COPD, heart problems, severe liver or kidney diseases, glaucoma, and malabsorption syndrome.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended to avoid alcohol consumption while taking Doxylamine Succinate+pyridoxal 5 Phosphate since it could lead to increased dizziness and drowsiness.
Pregnancy
safe if prescribedDoxylamine Succinate+pyridoxal 5 Phosphate is intended for use in pregnant women. However, please consult your doctor if you have any concerns.
Breast Feeding
cautionDoxylamine Succinate+pyridoxal 5 Phosphate passes into breast milk. Please consult your doctor if you are a nursing mother before starting Doxylamine Succinate+pyridoxal 5 Phosphate.
Driving
cautionDoxylamine Succinate+pyridoxal 5 Phosphate may cause dizziness, drowsiness, and tiredness; hence do not drive or operate heavy machinery if you feel dizzy.
Liver
cautionLet your doctor know if you have any history of liver diseases or hepatic impairment when you are prescribed Doxylamine Succinate+pyridoxal 5 Phosphate.
Kidney
cautionLet your doctor know if you have any history of kidney diseases when you are prescribed Doxylamine Succinate+pyridoxal 5 Phosphate.
Children
unsafeDoxylamine Succinate+pyridoxal 5 Phosphate is not recommended for children below 18 years of age, as the safety and efficacy have not been established.
Habit Forming
Diet & Lifestyle Advise
- Limit taking foods and drinks that contain chocolate, alcohol, caffeine, fructose, or sorbitol, carbonated drinks, fried, and fatty foods.
- Do not have large meals at a time, instead try having small and simpler meals at regular intervals, including fresh fruits and vegetables in your diet.
- Practice yoga and recreation techniques to manage your emotional stress.
- If you are lactose intolerant, avoid using dairy products since it can worsen your stomach discomfort.
- If you cannot take dairy products, it is advised to include other calcium-rich foods like leafy greens, beans, nuts, and seeds.
- Drink plenty of fluids to prevent dehydration.
- Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
Patients Concern
Disease/Condition Glossary
Morning sickness: It is a common symptom during pregnancy that usually happens within the first trimester (first three months) of pregnancy, but some pregnant women have it throughout pregnancy. In some cases, pregnant women experience excessive nausea and vomiting that progresses to a condition called hyperemesis gravidarum. It causes electrolyte imbalance and weight loss in pregnant women. The most common cause of morning sickness is increased hormone levels during the first weeks of pregnancy.
Nausea: It is an uneasy feeling in the stomach that may come and go in waves in which a person feels a strong urge to vomit. It happens before vomiting.
Vomiting: It is a natural response of the body in which a person expels stomach contents from the mouth forcefully. It can be triggered by taste, anxiety, smell, pain or irritation to the stomach.
FAQs
Doxylamine Succinate+pyridoxal 5 Phosphate contains Doxylamine succinate and Pyridoxal-5-phosphate (vitamin B6). Doxylamine succinate works by blocking the natural chemical (histamine) in the body, thereby preventing nausea and vomiting. Pyridoxal-5-phosphate works by increasing the level of vitamin B6 in the body and treating nausea and vomiting during pregnancy.
Please do not discontinue Doxylamine Succinate+pyridoxal 5 Phosphate without consulting your doctor. To treat your condition effectually, continue taking Doxylamine Succinate+pyridoxal 5 Phosphate for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Doxylamine Succinate+pyridoxal 5 Phosphate.
Doxylamine Succinate+pyridoxal 5 Phosphate may cause constipation as one of its side effects. You can avoid it by including high fibre food in your diet that helps improve digestion. Limit the intake of alcohol to manage your constipation.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose.
