Eplerenone+torsemide
About
Eplerenone+torsemide belongs to a class of medicine called 'diuretics' (water pills), primarily used to remove excess water from the body. It also maintains the bloodstream's potassium level and prevents hypertension (high blood pressure) due to Oedema (fluid retention). Oedema or fluid overload is associated with pulmonary hypertension (high blood pressure in the lung) or heart failure (irregular heart pumping). Leg swelling is the main characteristic of Oedema, accompanied by shortness of breath, chest pain (angina), abnormal heart rhythms (arrhythmia) and swelling in other hands or abdomen areas.
Eplerenone+torsemide is a combination of medications containing Eplerenone and Torsemide, which are prescribed for the treatment of resistant Oedema (fluid overload) associated with pulmonary hypertension (high blood pressure in the lungs), heart failure and hepatic cirrhosis (chronic liver damage). Eplerenone+torsemide works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats Oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain).
Take Eplerenone+torsemide as prescribed by your doctor. You are advised to take Eplerenone+torsemide for as long as your doctor has prescribed it. In some cases, you may experience dehydration, electrolyte disturbances (calcium, magnesium, and sodium), constipation, increased uric acid and itching. Most of these side effects of Eplerenone+torsemide do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Try not to stop taking Eplerenone+torsemide of your own, as doing so may raise your blood pressure, thereby increasing the risk of getting a heart attack and stroke. Inform your doctor if you suffer from any kidney, liver or heart disease. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Eplerenone+torsemide can be prescribed accordingly. Please tell your doctor if you are taking any other medicines or are allergic to Eplerenone+torsemide. Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling.
Uses of Eplerenone+torsemide
Medicinal Benefits
Eplerenone+torsemide is primarily used to remove excess water from the body. It also maintains the bloodstream's potassium level and prevents hypertension (high blood pressure) due to Oedema (fluid retention). Eplerenone+torsemide is a combination of medications containing Eplerenone and Torsemide. Both Eplerenone and Torsemide are diuretics and are prescribed for the treatment of resistant Oedema (fluid overload) associated with pulmonary hypertension (high blood pressure in the lungs), heart failure and hepatic cirrhosis (chronic liver damage). Eplerenone+torsemide works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats Oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain).
Directions for Use
Storage
Side Effects of Eplerenone+torsemide
- Dehydration
- Electrolyte disturbances (calcium, magnesium, and sodium)
- Constipation
- Itching
- Increased uric acid
In-Depth Precautions and Warning
Drug Warnings
Eplerenone+torsemide should not be given to the people allergic to Eplerenone+torsemide, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease (with creatinine clearance less than 30 mL/min), liver disease, pregnant women, or planning to get pregnant and breastfeeding women. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Eplerenone+torsemide can pass into breast milk, but its effect on the baby is unknown, so it is better to tell your doctor if you take Eplerenone+torsemide and breastfeeding. Dehydration with electrolyte and acid-base disturbances must be corrected before using Eplerenone+torsemide. Do not take extra potassium supplements or potassium-rich foods such as bananas and broccoli with Eplerenone+torsemide. It may lead to an excessive blood potassium level (hyperkalemia). Please take Eplerenone+torsemide at least 4 hours before sleeping to avoid frequent urination at night.
Drug Interactions
Drug-Drug Interactions: Eplerenone+torsemide may interact with other high blood pressure-lowering pills (e.g. metoprolol, ramipril, losartan), blood-thinning medicines (e.g. aspirin, warfarin), certain antibiotic medications (e.g. gentamicin, gentamycin, cephalexin, ceftriaxone, trimethoprim), certain medications used to treat skin certain skin conditions such as psoriasis or eczema (e.g. tacrolimus or ciclosporin), certain medicines used to treat bipolar disorder (e.g. lithium), certain medicines used for heart conditions (e.g. digoxin), certain NSAID medications (e.g. ibuprofen), certain antifungal medications (e.g. itraconazole), and medicines that affect potassium levels (e.g. spironolactone or amiloride).
Drug-Food Interactions: You are recommended not to consume alcohol along with Eplerenone+torsemide to avoid unpleasant side effects.
Drug-Disease Interactions: Eplerenone+torsemide interact with disease conditions including heart disorders, diabetes and microalbuminuria (persistent elevation of albumin in the urine), hyperkalemia (high potassium), anuria or renal dysfunction, liver disease or cirrhosis, electrolyte losses, ototoxicity (Ear Poisoning), and hyperuricemia (Elevated uric acid).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid consuming alcohol while on treatment with Eplerenone+torsemide as it may lead to serious side effects.
Pregnancy
cautionEplerenone+torsemide is generally not recommended during pregnancy. Talk to your doctor about the benefits and potential risks of taking this medicine if you're trying to get pregnant or are already pregnant.
Breast Feeding
cautionEplerenone+torsemide is generally not advised during breastfeeding. Eplerenone+torsemide should be used in breastfeeding mothers only if the benefits outweigh the risks.
Driving
cautionIt is not advised to drive after taking Eplerenone+torsemide because it may cause drowsiness due to orthostatic hypotension (sudden drop in blood pressure on standing from a lying position).
Liver
cautionEplerenone+torsemide to be taken with caution, especially if you have a history of Liver diseases/conditions. Your doctor may adjust the dose depending on your current liver conditions.
Kidney
cautionEplerenone+torsemide to be taken with caution, especially if you have a history of Kidney diseases/conditions. Your doctor may adjust the dose depending on your current kidney conditions.
Children
cautionEplerenone+torsemide is not recommended for children below 12 years of age.
Habit Forming
Diet & Lifestyle Advise
- Keep your weight under control with a BMI of 19.5-24.9.
- Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you lower your raised blood pressure by about 5 mm of Hg.
- Opt for a diet rich in whole grains, fruits, veggies and low-fat dairy products.
- Limit sodium chloride (table salt) intake in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
- If you take alcohol, only one serving for women and two servings for men is advisable.
- Quitting smoking is the best strategy to lower the risk of heart disease.
- Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
- Monitor your blood pressure daily, and if there is too much fluctuation, immediately contact your doctor.
- Try to include heart-healthy omega-3 fatty acids containing food and drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.
Special Advise
- Treatment with Eplerenone+torsemide requires regular monitoring of serum potassium, sodium and creatinine levels.
- Monitor your blood pressure daily, and if there is too much fluctuation, immediately contact your doctor.
- Regular monitoring of uric acid in patients with gouty arthritis.
Patients Concern
Disease/Condition Glossary
Oedema: Oedema or fluid overload is associated with pulmonary hypertension (high blood pressure in the lung) or heart failure (irregular heart pumping). The main characteristics of Oedema are leg swelling, shortness of breath, chest pain (angina), abnormal heart rhythms (arrhythmia) and swelling in other hands or abdomen areas.
Hypertension: Blood pressure measures our heart's force to pump blood to all body parts. Hypertension is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). High blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor. Systolic pressure is the pressure with which the heart pumps blood out. On the other hand, diastolic pressure is when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, the systolic pressure is 140 mm, and the diastolic pressure is 90 mm. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.
FAQs
Eplerenone+torsemide works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels and treats Oedema (swelling) associated with heart, liver, kidney or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it also helps lower high blood pressure, reducing the chances of any future heart attack, stroke or angina (chest pain).
Oedema, also known as dropsy, is the medical term for fluid retention in the body. The build-up of fluid causes affected tissue to become swollen. The swelling can occur in one particular part of the body – for example, due to an injury – or it can be more general. This is usually the case with Oedema due to certain health conditions, such as heart failure or kidney failure. If it does not subside, please consult your doctor immediately.
The main side effect of Eplerenone+torsemide is peeing (urination) more often than usual. Most people need to pee about 30 minutes after taking Eplerenone+torsemide and again within a few hours. Do not take Eplerenone+torsemide before going to bed, or you may have to frequently wake up in the night to go for urination.
Yes, Eplerenone+torsemide is known to cause dehydration (excessive loss of fluids). The patient may experience dry mouth, decreased urine output, excessive thirst, and hypotension (decreased blood pressure). So, please increase the intake of fluids to avoid excessive dehydration.
Yes, Eplerenone+torsemide can cause increased potassium levels (hyperkalemia), especially in patients with kidney problems or if you are taking potassium supplements along with Eplerenone+torsemide. Please monitor your electrolyte level regularly to avoid increasing blood potassium levels.
Yes, Eplerenone+torsemide may occasionally cause dizziness due to orthostatic hypotension (sudden drop in blood pressure on standing from lying position) or passing out. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
