Esomeprazole+domperidone
About
Esomeprazole+domperidone belongs to a group of gastrointestinal agents used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and stomach ulcers. The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, peptic ulcers and Zollinger-Ellison syndrome.
Esomeprazole+domperidone is a combination of two drugs: Esomeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Esomeprazole works by blocking an enzyme called gastric proton pump, which is responsible for the production of acid Domperidone works by increasing the movements and contractions of stomach muscle. Together, Esomeprazole+domperidone helps in treating acidity-related problems.
You are advised to take Esomeprazole+domperidone for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Consult your doctor before taking Esomeprazole+domperidone if you are pregnant or breastfeeding. Esomeprazole+domperidone may cause dizziness, so drive only if you are alert. Esomeprazole+domperidone should not be given to children as safety has not been established. Avoid consuming alcohol and Esomeprazole+domperidone as it could lead to increased drowsiness and elevate stomach acid production. Keep your doctor informed about your health condition and medicines to rule out any side-effects.
Uses of Esomeprazole+domperidone
Medicinal Benefits
Esomeprazole+domperidone is a combination of two drugs: Esomeprazole and Domperidone. Esomeprazole+domperidone is used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and stomach ulcers. It may also be indicated in the treatment of nausea, vomiting, fullness of the stomach, belching, heavy bloating, heartburn, acidity, gas, upper abdominal pain, erosive oesophagitis, and swallowing problems. Esomeprazole is a proton pump inhibitor that blocks an enzyme called gastric proton pump, responsible for acid production. Domperidone is a dopamine antagonist which works by increasing the movements and contractions of stomach muscles. Together, Esomeprazole+domperidone helps in treating acidity-related problems.
Directions for Use
Storage
Side Effects of Esomeprazole+domperidone
- Dry mouth
- Stomach pain
- Diarrhoea
- Headache
- Flatulence
In-Depth Precautions and Warning
Drug Warnings
Do not take Esomeprazole+domperidone if you are allergic to any of its contents or other proton pump inhibitors (such as pantoprazole, rabeprazole, lansoprazole or omeprazole); if you are taking nelfinavir (used to treat HIV); if you have prolactinoma (tumour of the pituitary gland), blockage in intestines, bleeding in stomach or intestine, moderate to severe liver disease, low level of potassium or magnesium or high levels of magnesium, or heart problems. Inform your doctor before taking Esomeprazole+domperidone if you have severe kidney, heart or liver disease, or if you are due to have Chromogranin A blood test; if you have fungal infections, heart problems or HIV infection. Talk to your doctor if you experience weight loss, problems with swallowing, stomach pain, indigestion, vomit food or blood, or if you pass black stools while taking Esomeprazole+domperidone. On long-term treatment, Esomeprazole+domperidone may cause low magnesium levels, vitamin B12 levels, and might increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition. Consult your doctor if you are pregnant or breastfeeding. Esomeprazole+domperidone may cause dizziness, so drive only if you are alert. Esomeprazole+domperidone should not be given to children as safety has not been established. Avoid consuming alcohol along with Esomeprazole+domperidone as it could lead to increased drowsiness and can elevate the production of stomach acid. A prolonged intake of Esomeprazole+domperidone is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor.
Drug Interactions
Drug-Drug Interactions: Esomeprazole+domperidone may interact with anti-HIV (atazanavir, nelfinavir, saquinavir, ritonavir), blood thinner (clopidogrel, warfarin), anti-fungal (ketoconazole, itraconazole, voriconazole, fluconazole), anti-cancer (erlotinib, toremifene, vandetanib, vincamine), benzodiazepine (diazepam), anti-convulsant (phenytoin), anti-platelet (Cilostazol), antacid (cisapride, dolasetron, prucalopride), immunosuppressant (tacrolimus), anti-TB (rifampicin), antibiotics (Erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine), a drug used to treat hypothyroidism (levothyroxine), anti-rheumatoid (methotrexate), anti-depressant (citalopram, escitalopram), cardiac glycoside (digoxin), anti-malarial (halofantrine), anti-psychotic (haloperidol, pimozide, sertindole), anti-allergy ( mequitazin, mizolastine), anti-arrhythmic (amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol), anti-hypertensives (diltiazem, verapamil), St.John’s wort (herbal supplement used to treat depression).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, prolactinoma (tumour of the pituitary gland), blockage in the intestines, bleeding in the stomach or intestine, moderate to severe liver disease, low level of potassium/magnesium, high levels of magnesium, or heart problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Esomeprazole+domperidone. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Pregnancy
cautionConsult your doctor before taking Esomeprazole+domperidone if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor before taking Esomeprazole+domperidone; your doctor will decide whether Esomeprazole+domperidone can be taken by breastfeeding mothers or not.
Driving
cautionEsomeprazole+domperidone may cause dizziness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor before taking Esomeprazole+domperidone if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Esomeprazole+domperidone if you have kidney impairment or any concerns regarding this.
Children
unsafeEsomeprazole+domperidone should not be given to children as safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating as it causes acid reflux.
- Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
- Practise relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes every hour by doing brisk walking or stretching.
Special Advise
- Inform your doctor before taking Esomeprazole+domperidone if you are due to have Chromogranin A blood test.
- Esomeprazole+domperidone may cause changes in blood tests. Inform the person doing the tests that you are taking Esomeprazole+domperidone.
Patients Concern
Disease/Condition Glossary
Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Stomach/Peptic ulcers: They are sores that develop on the stomach and intestine lining due to erosion of the stomach's protective lining. Symptoms include nausea, appetite changes, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
Zollinger-Ellison syndrome: It is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting.
FAQs
Esomeprazole+domperidone contains Esomeprazole and Domperidone. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of stomach muscles. Together, Esomeprazole+domperidone helps in treating acidity.
Diarrhoea might be a side-effect of Esomeprazole+domperidone. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you experience excessive diarrhoea or if you find blood in your stools.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Dry mouth could be a side-effect of Esomeprazole+domperidone. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help stimulate saliva and thereby prevent drying of the mouth.
Esomeprazole+domperidone contains domperidone which helps in treating nausea and vomiting by increasing the movements and contractions of stomach muscles.
Do not take Esomeprazole+domperidone for longer durations unless prescribed by the doctor. Consult your doctor if your condition does not improve even after taking Esomeprazole+domperidone for 14days.
Esomeprazole+domperidone should not be taken along with HIV medicines such as atazanavir, ritonavir, nelfinavir, and saquinavir as Esomeprazole+domperidone might affect their absorption. Consult your doctor before taking Esomeprazole+domperidone with other medicines to avoid unpleasant side-effects.
On long-term treatment, Esomeprazole+domperidone might increase the risk of bone fracture in the spine, wrist or hip. Inform your doctor if you have osteoporosis or if you are taking corticosteroids, as they can increase the risk of bone fractures.
