Hyaluronidase
About
Hyaluronidase belongs to a class of an enzyme primarily used together with fluids injected into the body to treat dehydration. It is also used to aid in the absorption of injections that are given into a muscle or under the skin. It is also used to enable excess fluids and blood in the tissues to be more easily re-absorbed. Besides this, it is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.
Hyaluronidase contains Hyaluronidase is an enzyme, a natural spreading or diffusing substance that activates processes in the body. It works by increasing the permeability of connective tissue through hyaluronic acid hydrolysis (a chemical substance that retains water to keep your tissues well-lubricated and moist). It is used to temporarily break down the natural barriers in the body tissues so that injections or fluids injected under the skin or into muscle are more easily spread and absorbed.
Hyaluronidase will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side-effects such as hormone imbalance, allergic reaction, slow growth in children and teenagers, angioedema (swelling of deeper layers of skin), dizziness, injection site reaction, edema (swelling). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Do not take Hyaluronidase if you are allergic to Hyaluronidase or any other contents present in it. Do not take Hyaluronidase if you are pregnant or breastfeeding unless prescribed. Care should be taken in children and elderly patients to control the speed, and total volume of fluid administered and avoid over-hydration, especially in renal impairment. It is unknown if Hyaluronidase alters your ability to drive, so be cautious while driving or operating machinery. Consult your doctor before consuming alcohol, along with Hyaluronidase. Keep your doctor informed about your health condition and medicines to rule out any side-effects.
Uses of Hyaluronidase
Medicinal Benefits
Hyaluronidase contains Hyaluronidase is an enzyme, a natural spreading or diffusing substance that activates processes in the body. It works by increasing the permeability of connective tissue through hyaluronic acid hydrolysis (a chemical substance that retains water to keep your tissues well lubricated and moist). It is used to temporarily break down the natural barriers in the body tissues so that injections or fluids injected under the skin or into muscle are more easily spread and absorbed. Hyaluronidase is also used to enable excess fluids and blood in the tissues to be more easily reabsorbed and help contrast dyes in your body show more clearly on certain types of x-rays or scans.
Directions for Use
Storage
Side Effects of Hyaluronidase
- Allergic reaction
- Hormone imbalance
- Skinn rash
- Slow growth in children and teenagers
- Angioedema (swelling of deeper layers of skin)
- Dizziness
- Injection site pain, redness
- Edema (swelling)
In-Depth Precautions and Warning
Drug Warnings
Hyaluronidase should not be injected into a vein (as an intravenous injection) because the enzyme is rapidly inactivated. If you have had cardiovascular disease, thyroid disease, diabetes, digital nerve block, ischemia of the fingers and toes, inform your doctor before taking Hyaluronidase. Use with caution in children and elderly patients. Inform your doctor before taking Hyaluronidase if you are pregnant or are nursing. Consumption of alcohol should be avoided during the treatment with Hyaluronidase as it may lead to increased risk of liver damage. Hyaluronidase should not be used for anesthetic procedures in cases of unexplained premature labor. Also, it should not be injected into or around an infected or inflamed area because of the danger of spreading a localized infection.
Drug Interactions
Drug-Drug Interaction: Hyaluronidase can interact with water pills (furosemide), antianxiety (diazepam, lorazepam, alprazolam), antiepileptic (phenytoin), pain killers (aspirin), hormones (estrogens).
Drug-Food Interaction: No interaction found.
Drug-Disease Interaction: People dealing with cardiovascular disease, thyroid disease, diabetes, digital nerve block, ischemia of the fingers and toes should take Hyaluronidase with caution.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is unknown if alcohol interacts with Hyaluronidase. Please consult your doctor before consuming alcohol, along with Hyaluronidase.
Pregnancy
cautionHyaluronidase is pregnancy category C drug. It can only be injected in pregnant women if suggested by the doctor as the safety and effectiveness of Hyaluronidase has not been established.
Breast Feeding
cautionHyaluronidase can only be injected in breastfeeding women when suggested by the doctor as safety and effectiveness of Hyaluronidase has not been established.
Driving
cautionIn some cases, Hyaluronidase may cause dizziness and drowsiness. So if you observe such symptoms, immediately consult your doctor.
Liver
cautionHyaluronidase can only be injected in persons dealing with liver disease if prescribed by a doctor.
Kidney
cautionHyaluronidase can only be injected in persons dealing with kidney disease if prescribed by a doctor.
Children
cautionHyaluronidase can be used in children only when prescribed by a doctor.
Habit Forming
Diet & Lifestyle Advise
- Acupuncture, massage, and physical therapy may also be helpful.
- Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
- Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.
- These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.
- Avoid smoking and alcohol consumption.
Special Advise
Your doctor may perform a skin test to see if you are allergic to Hyaluronidase before you receive]ing the medication.
Patients Concern
Disease/Condition Glossary
Drug absorption is a parameter in which the drug is absorbed from a pharmaceutical formulation into the bloodstream. Many patients with chronic diseases require injections as part of their prolonged medical therapy. Hypodermoclysis is a useful technique for the cure of dehydration in patients and especially for its prevention. Dehydration occurs when more water and fluids leave the body than enter it. Urography is radiography of any part of the urinary tract (kidneys, ureters, or bladder).
FAQs
Hyaluronidase contains Hyaluronidase, an enzyme that increases the permeability of connective tissue through the hydrolysis of hyaluronic acid and increases the diffusion of injected fluids or localized transudates exudates, thus facilitating their absorption.
Do not try to take injections on your own. Hyaluronidase has to be given by the registered medical practitioner (RMP) or doctor.
Yes, Hyaluronidase can cause dizziness in some patients. So, drive only if you are alert and omit driving or operating machinery if you feel dizzy or drowsy.
The common side-effects of Hyaluronidase are allergic reaction, hormone imbalance, slow growth in children and teenagers, angioedema (swelling of deeper layers of skin), dizziness, injection site reaction, edema (swelling).
A person of age 65 or older should use Hyaluronidase with caution, as directed by the doctor, as the chances of side effects increase in older people.
