Imeglimin
About
Imeglimin is an antidiabetic medicine used to treat diabetes. It is used for the treatment of Type II Diabetes. Type II Diabetes Mellitus is a serious condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels. Type II diabetes patients either do not create enough insulin, or the insulin they do make does not accomplish its purpose in the body (insulin resistance). This condition mostly occurs in middle-aged or older patients.
Imeglimin contains Imeglimin, which belongs to the aminotriazines class of antidiabetic medicine. It works in two ways: 1) increased glucose-stimulated insulin secretion (GSIS) and cell mass preservation; 2) improved insulin action, including the potential for reduction of hepatic glucose output and improvement in insulin signalling in both the liver and skeletal muscle. Diet management and exercise, along with treatment of Imeglimin are used to control blood sugar levels.
Imeglimin may cause certain side effects such as vomiting, nausea, abdominal pain, headache and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Imeglimin should be taken as prescribed by your doctor. It can be taken with or without food. The dose of the medicine will be decided by the doctor based on your disease condition.
Imeglimin should be avoided if you are allergic to any of the medicines or the components in it. Inform your doctor about your medical history and the medicines you are taking, including herbs and supplements, before starting the treatment with Imeglimin. This can help prevent unwanted effects. Imeglimin is not recommended for use in patients with severe liver or kidney disease. It is unknown whether Imeglimin can be given to pregnant women or breastfeeding mothers. Hence, inform your doctor if you are pregnant or breastfeeding before taking Imeglimin. It is not recommended for use in children below 18 years of age.
Uses of Imeglimin
Medicinal Benefits
Imeglimin contains Imeglimin, which belongs to the aminotriazines class of antidiabetic medicine. It works in two ways: 1) increased glucose-stimulated insulin secretion (GSIS) and cell mass preservation; 2) improved insulin action, including the potential for reduction of hepatic glucose output and improvement in insulin signalling in both the liver and skeletal muscle. Diet management and exercise, along with treatment of Imeglimin are used to control blood sugar levels.
Directions for Use
Storage
Side Effects of Imeglimin
- Headache
- Nausea
- Stomach upset
- Vomiting
- Abdominal pain
In-Depth Precautions and Warning
Drug Warnings
Imeglimin should be avoided if you are allergic to any of the medicines or the components in it. Before starting the treatment, inform your doctor about your medical history and the medications you take, including herbs and supplements. This can help prevent unwanted effects. Imeglimin is not recommended for use in patients with severe liver or kidney disease. It is unknown whether Imeglimin can be given to pregnant women or breastfeeding mothers. Hence, inform your doctor if you are pregnant or breastfeeding. It is not recommended for use in children below 18 years of age.
Drug Interactions
Drug-Drug Interactions: Imeglimin interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine).
Drug-Food Interactions: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Imeglimin.
Drug-Disease Interactions: Inform your doctor if you have any kidney or liver disease or heart problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is unknown whether Imeglimin will interact with alcohol. Please consult a doctor before consuming alcohol while on treatment with Imeglimin.
Pregnancy
cautionImeglimin is not recommended in pregnancy as it may cross the placental barrier and harm your foetus. If you are pregnant or planning pregnancy, inform your doctor before taking Imeglimin.
Breast Feeding
cautionImeglimin passes into the breastmilk in traces. Hence, if you are breastfeeding, inform your doctor before taking Imeglimin. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Driving
not applicableImeglimin usually does not affect your ability to drive or operate machinery.
Liver
cautionUse Imeglimin with caution, especially if you have a history of liver disease. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Kidney
cautionUse Imeglimin with caution, especially if you have a history of kidney disease. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Children
unsafeImeglimin is not recommended for children below 18 years as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Try doing 30 minutes of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise weekly.
- Include your diet with whole grain foods, fruits and veggies and other fiber-enriched foods.
- Add omega-3 fatty acid-containing oils for daily cooking.
- Avoid taking too much stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes, meditation, or yoga.
- Loss of weight gradually to achieve a healthy body mass index (18.5 to 24.9).
- Keep your blood pressure as normal (140/90) as possible, as it reduces the risk of cardiovascular diseases in diabetes patients.
- Avoid smoking and alcohol consumption while on treatment with Imeglimin.
- Take short, frequent meals, and avoid prolonged fasting when taking Imeglimin.
Special Advise
- Imeglimin may sometimes cause hypoglycemia (low blood sugar levels) as a side effect. Try to carry candies or sugar biscuits in your pocket every time you feel symptoms such as sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc.
- Inform your physician about all your underlying conditions, like kidney disease or liver disease, prior heart attack, alcohol intake, etc., before the doctor prescribes you Imeglimin.
- Avoid drinking alcohol while on Imeglimin as it increases the risk of hypoglycemia (decrease in blood sugar, which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).
- Lifestyle modifications are the most important step in controlling blood sugar levels.
- Your doctor may advise frequent blood tests to check your blood sugar levels.
Patients Concern
Disease/Condition Glossary
Type II Diabetes Mellitus: It is a chronic and lifelong condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels. Therefore, people affected with type 2 diabetes either do not produce enough insulin or there is resistance to the action of insulin. Individuals middle-aged or older are most likely to suffer from type 2 diabetes, which is also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, weight gain, and blurred vision. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increased chance of heart attack or stroke.
FAQs
Imeglimin contains Imeglimin, which belongs to the aminotriazines class of antidiabetic medicine. It works in two ways: 1) increased glucose-stimulated insulin secretion (GSIS) and cell mass preservation; 2) improved insulin action, including the potential for reduction of hepatic glucose output and improvement in insulin signalling in both the liver and skeletal muscle.
Yes, Imeglimin can cause a minor upset of the stomach. However, do not stop taking it. Discuss with your doctor in case of severe stomach upset.
Please consult your doctor if you have concerns and for more information on this.
If you forget to take Imeglimin, take it as soon as you remember. However, if it's time for the next dose, avoid taking it and do not double dose to make up for your forgotten dose. Taking an overdose might cause your sugar level to fall down rapidly.
