Isoniazid+pyrazinamide+pyridoxine+rifampicin
About
Isoniazid+pyrazinamide+pyridoxine+rifampicin belongs to the group of medicines called 'anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine, and bone marrow. Isoniazid+pyrazinamide+pyridoxine+rifampicin does not work against infections caused by the virus, such as the common cold and flu.
Isoniazid+pyrazinamide+pyridoxine+rifampicin is a combination of four drugs: Isoniazid, Pyrazinamide, Pyridoxine (vitamin B6), and Rifampicin. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the bacterial cell wall. Pyrazinamide is an antibiotic that works by stopping the growth of bacteria that cause tuberculosis. Pyridoxine treats nerve damage (neuritis) caused by tuberculosis. Rifampicin inhibits DNA dependent RNA polymerase activity in the bacteria.
Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of Isoniazid+pyrazinamide+pyridoxine+rifampicin include muscle/joint pain, nausea, vomiting, rash, dark coloured urine, weakness, dry mouth, stomach pain, and upset stomach. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.
Avoid foods and drinks that contain histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking Isoniazid+pyrazinamide+pyridoxine+rifampicin as they may interact. Maintain a gap of one hour between Isoniazid+pyrazinamide+pyridoxine+rifampicin and antacid medicines. Isoniazid+pyrazinamide+pyridoxine+rifampicin may cause dizziness, and vision problems, so drive with caution. It is essential to let your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother. Avoid consuming alcohol along with Isoniazid+pyrazinamide+pyridoxine+rifampicin as it might lead to liver problems. Isoniazid+pyrazinamide+pyridoxine+rifampicin is not recommended for use in children unless the doctor has prescribed it.
Uses of Isoniazid+pyrazinamide+pyridoxine+rifampicin
Medicinal Benefits
Isoniazid+pyrazinamide+pyridoxine+rifampicin contains Isoniazid, Pyrazinamide, Pyridoxine (vitamin B6), and Rifampicin. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the bacterial cell wall. Pyrazinamide is an antibiotic that stops the growth of bacteria that cause tuberculosis. Pyridoxine (vitamin B6) treats nerve damage (neuritis) caused by tuberculosis. Rifampicin inhibits DNA dependent RNA polymerase activity in the bacteria. Together, Isoniazid+pyrazinamide+pyridoxine+rifampicin kills Mycobacterium tuberculosis which causes TB (tuberculosis).
Directions for Use
Storage
Side Effects of Isoniazid+pyrazinamide+pyridoxine+rifampicin
- Muscle/joint pain
- Nausea
- Vomiting
- Rash
- Dark coloured urine
- Weakness
- Dry mouth
- Stomach pain
- Upset stomach
In-Depth Precautions and Warning
Drug Warnings
Do not take Isoniazid+pyrazinamide+pyridoxine+rifampicin if you are allergic to any of its contents, if you have jaundice, or take HIV medicines (saquinavir or ritonavir). Before starting Isoniazid+pyrazinamide+pyridoxine+rifampicin, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, and kidney or liver problems. Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking Isoniazid+pyrazinamide+pyridoxine+rifampicin as they might cause interaction. Maintain a gap of one hour between Isoniazid+pyrazinamide+pyridoxine+rifampicin and antacid medicines. Consult your doctor before taking Isoniazid+pyrazinamide+pyridoxine+rifampicin if you are pregnant. Avoid breastfeeding while taking Isoniazid+pyrazinamide+pyridoxine+rifampicin as it passes into breast milk. Isoniazid+pyrazinamide+pyridoxine+rifampicin may cause dizziness, and vision problems, so drive with caution. Avoid alcohol consumption while taking Isoniazid+pyrazinamide+pyridoxine+rifampicin as it could lead to increased liver damage. Store Isoniazid+pyrazinamide+pyridoxine+rifampicin below 25°C away from direct sunlight.
Drug Interactions
Drug-Drug Interaction: Isoniazid+pyrazinamide+pyridoxine+rifampicin may interact with antibiotics (erythromycin), pain killers (acetaminophen), anti-diabetic drugs (insulin isophane), anti-HIV drugs (saquinavir, ritonavir), supplements (ergocalciferol), gout medicines (probenecid, sulfinpyrazone), and oral contraceptives.
Drug-Food Interaction: Do not consume alcohol while taking Isoniazid+pyrazinamide+pyridoxine+rifampicin as it could lead to increased dizziness and liver damage. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking Isoniazid+pyrazinamide+pyridoxine+rifampicin as they might cause interaction.
Drug-Disease Interaction: Isoniazid+pyrazinamide+pyridoxine+rifampicin may interact with colitis (inflammation in the lining of the colon), peripheral neuropathy (numbness and pain in hands and feet), porphyria, haemodialysis, diabetes, gout (high uric acid), liver toxicity, dialysis, optic neuritis (vision problems), kidney, and liver dysfunction.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended to avoid alcohol consumption while taking Isoniazid+pyrazinamide+pyridoxine+rifampicin. Alcohol intake, along with Isoniazid+pyrazinamide+pyridoxine+rifampicin, may cause increased liver damage. Please consult your doctor for more information.
Pregnancy
cautionPlease consult your doctor if you are pregnant, planning for pregnancy or think you are pregnant; your doctor will prescribe Isoniazid+pyrazinamide+pyridoxine+rifampicin only if the benefits outweigh the risks.
Breast Feeding
unsafeIsoniazid+pyrazinamide+pyridoxine+rifampicin is not recommended for use during breastfeeding since it is excreted into the breast milk and may harm a nursing baby. However, please consult your doctor before taking Isoniazid+pyrazinamide+pyridoxine+rifampicin if you are a breastfeeding mother.
Driving
unsafeIsoniazid+pyrazinamide+pyridoxine+rifampicin may cause dizziness, vision problems, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.
Liver
cautionPlease consult your doctor since Isoniazid+pyrazinamide+pyridoxine+rifampicin should be used with caution in patients with liver impairment/liver disease. Regular monitoring of liver function tests is also advised.
Kidney
cautionPlease consult your doctor since Isoniazid+pyrazinamide+pyridoxine+rifampicin should be used with caution in patients with kidney impairment/kidney disease. Your doctor may adjust the dosage in case of renal dysfunction.
Children
cautionIsoniazid+pyrazinamide+pyridoxine+rifampicin is not recommended in children unless the doctor has prescribed it.
Habit Forming
Diet & Lifestyle Advise
- Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
- Foods rich in vitamin C, such as kiwi, broccoli, and bell pepper, help improve the immune system.
- Avoid processed and fried foods.
- Warm ginger tea or warm soup can help in providing relief from cough.
- Avoid foods and drinks, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
- Quit smoking and avoid alcohol consumption.
Special Advise
- Let your doctor know that you are taking Isoniazid+pyrazinamide+pyridoxine+rifampicin if you are undergoing any medical tests.
- Your doctor may advise liver enzymes and uric acid levels tests before you start treatment to make sure you can safely take Isoniazid+pyrazinamide+pyridoxine+rifampicin.
- It is advised to undergo liver functioning tests to keep a check on your liver function.
Patients Concern
Disease/Condition Glossary
Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease that can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.
FAQs
Isoniazid+pyrazinamide+pyridoxine+rifampicin contains Isoniazid, Pyrazinamide, Pyridoxine (vitamin B6), and Rifampicin. Isoniazid+pyrazinamide+pyridoxine+rifampicin interferes with the growth and tuberculosis causing bacteria and kills it. Thus Isoniazid+pyrazinamide+pyridoxine+rifampicin effectively treats TB (tuberculosis).
Isoniazid+pyrazinamide+pyridoxine+rifampicin might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception, such as condoms or the coil while taking Isoniazid+pyrazinamide+pyridoxine+rifampicin. Consult your doctor if you have any concerns regarding this; your doctor may suggest an alternate contraception method.
Isoniazid+pyrazinamide+pyridoxine+rifampicin may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time even after you stop taking Isoniazid+pyrazinamide+pyridoxine+rifampicin. Do not worry, as it is a common side-effect of Isoniazid+pyrazinamide+pyridoxine+rifampicin.
Isoniazid+pyrazinamide+pyridoxine+rifampicin can affect live vaccines like typhoid vaccine and decrease their effectiveness. Please consult a doctor before you start Isoniazid+pyrazinamide+pyridoxine+rifampicin if you are undergoing any vaccinations.
Yes, Isoniazid+pyrazinamide+pyridoxine+rifampicin might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lens while taking Isoniazid+pyrazinamide+pyridoxine+rifampicin.
Isoniazid+pyrazinamide+pyridoxine+rifampicin may cause liver problems, especially in people who are 35 and older. Consult your doctor if you notice symptoms, such as yellowing of eyes or skin, dark urine, pale stools, weakness, loss of appetite, nausea or vomiting. Your doctor may advise you to get regular liver tests while taking Isoniazid+pyrazinamide+pyridoxine+rifampicin to check how your liver functions.
