Lafutidine+domperidone
About
Lafutidine+domperidone belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.
Lafutidine+domperidone is a combination of two drugs: Lafutidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Lafutidine works by blocking histamine H2 receptors located on the stomach lining, thereby reduces gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscles.
You are advised to take Lafutidine+domperidone for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects, such as nausea, diarrhoea, dryness in the mouth, headache, drowsiness, dizziness, increased liver enzymes, and increased uric acid level in the blood. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Inform your doctor before taking Lafutidine+domperidone if you have a history of gastrointestinal bleeding, intestinal obstruction, liver disease, kidney disease. Do not take Lafutidine+domperidone if you are pregnant or breastfeeding unless prescribed by the doctor. Lafutidine+domperidone may cause sleepiness and dizziness, so drive only if you are alert. Lafutidine+domperidone should not be given to children as safety has not been established. Avoid consuming alcohol along with Lafutidine+domperidone as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side-effects.
Uses of Lafutidine+domperidone
Medicinal Benefits
Lafutidine+domperidone belongs to a group of gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. Lafutidine+domperidone is a combination of two drugs: Lafutidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Lafutidine works by blocking histamine H2 receptors located on the stomach lining, thereby reduces gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscles.
Directions for Use
Storage
Side Effects of Lafutidine+domperidone
- Nausea
- Dryness in mouth
- Headache
- Drowsiness
- Dizziness
- Protein in urine
- Increased uric acid level in the blood
In-Depth Precautions and Warning
Drug Warnings
Do not take Lafutidine+domperidone if you are allergic to any of its contents. Inform your doctor before taking Lafutidine+domperidone if you have a history of gastrointestinal bleeding or intestinal obstruction. Do not take Lafutidine+domperidone if you are pregnant or breastfeeding unless prescribed by the doctor. Lafutidine+domperidone may cause drowsiness and dizziness, so drive only if you are alert. Lafutidine+domperidone should not be given to children as safety has not been established. Avoid consuming alcohol along with Lafutidine+domperidone as it could lead to increased drowsiness and can elevate the production of stomach acid. The Lafutidine+domperidone contains lafutidine which may mask gastric cancer symptoms, so Lafutidine+domperidone should be taken only after confirming the tumour is not malignant.
Drug Interactions
Drug-Drug Interactions: Lafutidine+domperidone may have interaction with antifungals (ketoconazole, fluconazole, posaconazole), medication for HIV/AIDS (saquinavir, darunavir), medication for heart diseases (bepridil), allergy medication (terfenadine), antimalarial medication (piperaquine) and antibiotic (sparfloxacin)
Drug-Food Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Drug-Disease Interactions: Lafutidine+domperidone may have interactions with gastrointestinal bleeding, pituitary (brain) tumour, hemodialysis, liver, and kidney dysfunction.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Lafutidine+domperidone. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Pregnancy
cautionConsult your doctor before taking Lafutidine+domperidone if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor before taking Lafutidine+domperidone; your doctor will decide whether Lafutidine+domperidone can be taken by breastfeeding mothers or not.
Driving
cautionLafutidine+domperidone may cause dizziness and sleepiness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor before taking Lafutidine+domperidone if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Lafutidine+domperidone if you have kidney impairment or any concerns regarding this.
Children
unsafeLafutidine+domperidone should not be given to children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating.
- Avoid tight-fitting clothes.
- Maintain a healthy weight by regular exercising.
- Practice relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes break every hour by doing brisk walking or stretching
Special Advise
Patients Concern
Disease/Condition Glossary
The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of stomach protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
FAQs
Lafutidine+domperidone is a combination of two drugs: Lafutidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Lafutidine works by blocking histamine H2 receptors located on the stomach lining, thereby reduces gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscle. Together, Lafutidine+domperidone helps in relieving symptoms of gastroesophageal reflux disease.
Talk to your doctor if you do not feel better even after taking Lafutidine+domperidone for 7 days. Do not take Lafutidine+domperidone for longer durations unless prescribed by the doctor.
Constipation might be a side-effect of Lafutidine+domperidone. Drink enough fluids and eat fibre rich food if you experience constipation.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Dry mouth could be a side-effect of Lafutidine+domperidone. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Lafutidine+domperidone contains domperidone which helps in treating nausea and vomiting. However, Lafutidine+domperidone is used to treat acidity related conditions. Please consult your doctor, he/she may prescribe you an alternate medicine for treating nausea and vomiting.
