Mecobalamin+pregabalin+nortriptyline
About
Mecobalamin+pregabalin+nortriptyline is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).
Mecobalamin+pregabalin+nortriptyline combines three drugs: Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin is a vitamin that aids in producing myelin, which protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Mecobalamin+pregabalin+nortriptyline helps to treat neuropathic pain.
Take Mecobalamin+pregabalin+nortriptyline as prescribed. Your doctor will decide the dose and duration based on your medical condition. In some cases, Mecobalamin+pregabalin+nortriptyline may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. These side effects do not necessitate medical attention and will subside gradually over time. However, you should consult your doctor if you are experiencing these side effects regularly.
Please do not take Mecobalamin+pregabalin+nortriptyline if you are allergic to any of its ingredients. Consult your doctor before taking Mecobalamin+pregabalin+nortriptyline if you are pregnant or breastfeeding. Mecobalamin+pregabalin+nortriptyline may cause drowsiness and dizziness, so drive only if alert. Mecobalamin+pregabalin+nortriptyline should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol with Mecobalamin+pregabalin+nortriptyline as it could increase dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to avoid side effects.
Uses of Mecobalamin+pregabalin+nortriptyline
Medicinal Benefits
Mecobalamin+pregabalin+nortriptyline is a combination of three drugs: Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin+pregabalin+nortriptyline is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Mecobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Mecobalamin+pregabalin+nortriptyline helps to treat neuropathic pain.
Directions for Use
Storage
Side Effects of Mecobalamin+pregabalin+nortriptyline
- Constipation
- Dry mouth
- Headache
- Feeling sleepy, tired or dizzy
- Diarrhoea
In-Depth Precautions and Warning
Drug Warnings
If you are allergic to any of the ingredients in Mecobalamin+pregabalin+nortriptyline, do not consume it. Please do not stop taking Mecobalamin+pregabalin+nortriptyline without consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Mecobalamin+pregabalin+nortriptyline unless your doctor has prescribed it. Mecobalamin+pregabalin+nortriptyline may cause drowsiness and dizziness; therefore, drive only if alert. Mecobalamin+pregabalin+nortriptyline is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Mecobalamin+pregabalin+nortriptyline as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.
Drug Interactions
Drug-Drug Interactions: Mecobalamin+pregabalin+nortriptyline may have interaction with antidepressant medications (e.g. duloxetine, sertraline, escitalopram), pain killer medications (e.g. codeine, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), anti-convulsant medications (e.g. topiramate), anti-anxiety medications (e.g. alprazolam), sedative-hypnotics medications (e.g. zolpidem), antihistamine medications (e.g. diphenhydramine, cetirizine), muscle relaxant medications (e.g. cyclobenzaprine), antiemetic medications (e.g. ondansetron), and herbal medications to treat depression (e.g. St John's wort).
Drug-Food Interactions: Avoid alcohol consumption while taking Mecobalamin+pregabalin+nortriptyline as it might cause increased drowsiness and sleepiness.
Drug-Disease Interactions: Use Mecobalamin+pregabalin+nortriptyline with medical advice if you have had anticholinergic effects, cardiovascular disease, pheochromocytoma, acute myocardial infarction recovery, cardiovascular disease, depression, seizure disorders, drug dependence, suicidal tendency, angioedema, creatine kinase elevations, peripheral oedema, PR interval prolongation, bone marrow suppression, diabetes, renal/liver disease, schizophrenia/bipolar disorder, hyper/hypoglycemia, schizophrenia, thyroid disorders and urinary retention.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Mecobalamin+pregabalin+nortriptyline as it may increase drowsiness and sleepiness.
Pregnancy
cautionIf you're pregnant, don't take Mecobalamin+pregabalin+nortriptyline unless your doctor tells you to. Please consult your doctor if you have any concerns about this; your doctor will only prescribe if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor as there is no substantial research yet on the use of Mecobalamin+pregabalin+nortriptyline in breastfeeding/nursing mothers.
Driving
cautionMecobalamin+pregabalin+nortriptyline causes drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.
Liver
cautionInform your doctor before receiving the Mecobalamin+pregabalin+nortriptyline if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.
Kidney
cautionInform your doctor before receiving the Mecobalamin+pregabalin+nortriptyline if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.
Children
unsafeMecobalamin+pregabalin+nortriptyline should not be given to children as the safety and efficacy have not been established.
Habit Forming
Diet & Lifestyle Advise
- Include vitamin B and D-rich foods in your diet.
- Your diet should include Cayenne pepper because it can help with neuropathic pain.
- Exercising regularly helps to improve overall health and combat pain.
- Rest well and get plenty of rest.
- Taking a warm bath can be very relaxing.
- Avoid smoking and drinking alcohol.
- Meditation and yoga can reduce stress, and pain sensitivity, and improve coping skills.
- Acupuncture, by stimulating pressure points, can be beneficial.
- Massages with essential oils can help increase circulation.
Special Advise
Mecobalamin+pregabalin+nortriptyline contains Nortriptyline (antidepressant), which can lead to suicidal thoughts. Suicidal thoughts or behaviour should be closely monitored in people taking Mecobalamin+pregabalin+nortriptyline. If you have suicidal thoughts, don't hesitate to talk to your doctor immediately.
Patients Concern
Disease/Condition Glossary
Neuropathic pain: Neuropathic pain is caused due to damaged sensory nerves. It is caused by chronic progressive nerve disease or due to infection or injury. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also familiar with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury. The body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping and evoked pain (pain caused by events usually not painful).
FAQs
Mecobalamin+pregabalin+nortriptyline contains Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Together, Mecobalamin+pregabalin+nortriptyline helps to treat neuropathic pain.
Mecobalamin+pregabalin+nortriptyline contains pregabalin. It may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.
Dry mouth could be a side-effect of Mecobalamin+pregabalin+nortriptyline. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Do not stop taking Mecobalamin+pregabalin+nortriptyline without consulting your doctor, as this could result in withdrawal symptoms. Continue taking Mecobalamin+pregabalin+nortriptyline for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking Mecobalamin+pregabalin+nortriptyline, do not be afraid to speak with your doctor.
Mecobalamin+pregabalin+nortriptyline is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.
Mecobalamin+pregabalin+nortriptyline may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.
