Mefenamic Acid+tizanidine
About
Mefenamic Acid+tizanidine belongs to a group of NSAID (Non-Steroidal Anti-Inflammatory Drug) medicines used to provide relief from abdominal cramps caused before and during the menstrual cycle. Abdominal cramps are throbbing pains in the lower abdomen due to the menstrual cycle every month in females. In some females, the pain and discomfort caused due to menstruation are so severe that they have to take some medicine to lower the pain intensity.
Mefenamic Acid+tizanidine is a combination drug that contains 'mefenamic acid' and 'Tizanidine.' Mefenamic acid works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes, that make another chemical, 'prostaglandins' (PG) which are responsible for causing pain. Tizanidine works on the centres of the spinal cord and brain. This helps relax the intestine or stomach muscles and stops muscle contractions. Collectively, both of them help to relieve pain, bloating, cramps, and discomfort caused.
Take Mefenamic Acid+tizanidine as prescribed. Depending on your medical condition, you are advised to take Mefenamic Acid+tizanidine for as long as your doctor has prescribed it for you. In some cases, you may experience common side effects, such as abdominal pain, nausea, vomiting, diarrhoea, indigestion, weakness, dry mouth, and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Please inform your doctor if you are allergic to Mefenamic Acid+tizanidine or other medicines. Mefenamic Acid+tizanidine can increase the risk of fatal heart attack or stroke, gastrointestinal bleeding, ulceration, and perforation of the stomach and intestines. Do not take Mefenamic Acid+tizanidine if you are pregnant or breastfeeding unless prescribed by the doctor. Mefenamic Acid+tizanidine may cause drowsiness and dizziness, so drive with caution. Mefenamic Acid+tizanidine should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol and Mefenamic Acid+tizanidine as it could lead to increased drowsiness and dizziness; it might also increase stomach bleeding risk. Do not take other painkillers with Mefenamic Acid+tizanidine unless prescribed by the doctor. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Uses of Mefenamic Acid+tizanidine
Medicinal Benefits
Mefenamic Acid+tizanidine is a combination drug that contains 'mefenamic acid' and 'Tizanidine.' Mefenamic acid belongs to a group of medicines called NSAID (Non-Steroidal Anti-Inflammatory Drug), used to relieve mild to moderate pain associated with period pain, symptoms of premenstrual syndrome (PMS), and management of excessively heavy periods. Mefenamic Acid+tizanidine works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical, 'prostaglandins' (PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzymes' effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Tizanidine works in the centres of the spinal cord and brain. This helps relax the intestine or stomach muscles and stops muscle contractions. Collectively, both of them help to relieve pain, bloating, cramps, and discomfort caused.
Directions for Use
Storage
Side Effects of Mefenamic Acid+tizanidine
- Abdominal pain
- Nausea
- Vomiting
- Diarrhoea
- Indigestion
- Heartburn
- Weakness
- Dryness in the mouth
In-Depth Precautions and Warning
Drug Warnings
Please inform your doctor if you are allergic to Mefenamic Acid+tizanidine or other medicines. Mefenamic Acid+tizanidine can increase the risk of fatal heart attack or stroke, gastrointestinal bleeding, ulceration, and perforation of the stomach and intestines. Do not take Mefenamic Acid+tizanidine if you are pregnant or breastfeeding unless prescribed by the doctor. Mefenamic Acid+tizanidine may cause drowsiness and dizziness, so drive with caution. Mefenamic Acid+tizanidine should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol and Mefenamic Acid+tizanidine as it could lead to increased drowsiness and dizziness; it might also increase stomach bleeding risk. Do not take other painkillers with Mefenamic Acid+tizanidine unless prescribed by the doctor. Keep your doctor informed about your health condition and medicines to rule out any side effects. Avoid taking Mefenamic Acid+tizanidine with fluvoxamine and ciprofloxacin as it may cause adverse effects such as slurred speech, dizziness, weakness, confusion, low blood pressure, or drowsiness. You are advised not to take more than three doses of Mefenamic Acid+tizanidine in a single day as too much of Mefenamic Acid+tizanidine may cause liver damage. If you have low blood pressure or liver or kidney diseases, inform your doctor before taking Mefenamic Acid+tizanidine.
Drug Interactions
Drug-Drug Interactions: Mefenamic Acid+tizanidine may have interaction with pain killers (aspirin, ibuprofen, celecoxib, diclofenac, naproxen), anti-gout (probenecid), immunosuppressants (cyclosporine, tacrolimus), anticoagulants (warfarin, heparin), anti-rheumatoid (methotrexate), anti-HIV (zidovudine), anti-depressant (duloxetine, lithium, fluoxetine, sertraline), steroid medication (mifepristone), anti-allergic drugs (diphenhydramine, cetirizine), an anti-anxiety drug (alprazolam), sedative-hypnotic drug (zolpidem), bronchodilator (albuterol), antibiotic (ciprofloxacin).
Drug-Food Interactions: Avoid alcohol consumption while taking Mefenamic Acid+tizanidine as it might cause increased dizziness and risk of stomach bleeding.
Drug-Disease Interactions: Mefenamic Acid+tizanidine may have interactions with patients having peptic ulcers, bleeding disorders, asthma, fluid retention, gastrointestinal toxicity, rash, renal toxicity, thrombosis, anaemia, heart failure, liver toxicity, high blood pressure, platelet aggregation inhibition, and hyperkalemia (high potassium levels).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended to avoid alcohol consumption with Mefenamic Acid+tizanidine as it may increase the risk of adverse effects.
Pregnancy
cautionMefenamic Acid+tizanidine belongs to pregnancy category C. Please consult your doctor before taking the Mefenamic Acid+tizanidine if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionIt is unknown whether Mefenamic Acid+tizanidine is excreted in human milk. Therefore, please consult a doctor if you are breastfeeding. Mefenamic Acid+tizanidine is given to breastfeeding mothers only if the doctor thinks the benefits outweigh the risks.
Driving
cautionMefenamic Acid+tizanidine may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
unsafeMefenamic Acid+tizanidine should not be given to children as safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Massages can also be helpful.
- Avoid having too spicy and junk food and instead eat home-cooked food as it will help to lower contracting and make the job of the stomach easier.
- Avoid freezing and hot temperatures.
- Avoid wearing tight-fitting clothes; instead, wear loose garments.
- Rest well, and get plenty of sleep.
- Stay hydrated, and drink plenty of water.
Special Advise
Regular blood tests are recommended to monitor liver functioning while taking Mefenamic Acid+tizanidine.
Patients Concern
Disease/Condition Glossary
Abdominal cramps: Abdominal cramps are the throbbing pains in the lower abdomen due to menstruation every month in females. Menstruation is the release of blood in females in the fertilization of the egg that does not take place. In some females, the pain and discomfort caused due to menstruation are so severe that they have to take some medicine to lower the pain intensity. It generally occurs one to two days before the menses and lasts till the day menses are over.
FAQs
Mefenamic Acid+tizanidine is used to provide relief from abdominal cramps caused before and during the menstrual cycle. Mefenamic Acid+tizanidine is a combination drug that contains 'mefenamic acid' and 'Tizanidine.' Mefenamic acid works by blocking the effect of a chemical messenger in your body, which is responsible for causing pain. Tizanidine works in the centres of the spinal cord and brain. This helps relax the intestine or stomach muscles and stops muscle contractions. Collectively, both of them help to relieve pain, bloating, cramps, and discomfort caused.
Mefenamic Acid+tizanidine is used to relieve menstrual (period) pain, premenstrual syndrome (PMS) symptoms, and management of excessively heavy periods. Take only as prescribed by the doctor.
You are not recommended to take Mefenamic Acid+tizanidine with ciprofloxacin as Mefenamic Acid+tizanidine contains Tizanidine. Co-administrating these two medicines may cause adverse effects such as slurred speech, dizziness, weakness, confusion, low blood pressure, and drowsiness. However, please consult a doctor before taking Mefenamic Acid+tizanidine with other medicines.
Avoid taking Mefenamic Acid+tizanidine if you have stomach ulcers as Mefenamic Acid+tizanidine contains Mefenamine, which might increase the risk of stomach ulcers, perforation of the stomach and intestinal bleeding with higher doses.
Do not take Mefenamic Acid+tizanidine if you are planning for pregnancy as Mefenamic Acid+tizanidine might make it more difficult to get pregnant.
Diarrhoea might be a side-effect of Mefenamic Acid+tizanidine. Drink plenty of fluids and eat food rich in fibre. Consult your doctor if you experience excessive diarrhoea or if you find blood in stools.
