Moxifloxacin+loteprednol
About
Moxifloxacin+loteprednol belongs to a group of medications called 'Antibiotics and Corticosteroids' used to treat bacterial eye infections or eye discomfort. It is also used in patients who have undergone eye surgeries. It is effectively used to treat eye inflammation caused by allergies, shingles, severe acne, iritis (inflammation of the coloured part of the eye (iris)), uveitis (inflammation of the middle layer of the eye (uvea)), eye injury, radiation, and chemical burns. A bacterial eye infection occurs when bacteria invade any part of the eyeball or its surrounding tissues, including the cornea (clear front surface of the eye) and the conjunctiva (thin membrane lining the outer eye and inner eyelids). Moxifloxacin+loteprednol is used to prevent or treat only bacterial eye infections. It does not work against infections caused by viruses and fungi.
Moxifloxacin+loteprednol contains two medicines: Moxifloxacin (antibiotic) and Loteprednol (corticosteroid). Moxifloxacin belongs to a class of drugs called fluoroquinolone antibiotics. Moxifloxacin is an antibiotic that helps treat and prevent a wide range of bacterial infections. It kills bacteria (bactericidal action) by preventing the synthesis of enzymes, namely DNA gyrase and Topoisomerase II and IV, which is essential for the growth and survival of the bacterial cell. Loteprednol belongs to the class of corticosteroids. It blocks prostaglandins' production (chemical messengers), making the eye red, swollen, and itchy. Together, Moxifloxacin+loteprednol prevents the spread of eye infections caused by bacteria and reduces inflammation and pain.
Moxifloxacin+loteprednol is available in the form of an ophthalmic solution (eye drops). Your doctor will advise on how often you take Moxifloxacin+loteprednol based on your medical condition. Some common side effects of eye drop formulation of Moxifloxacin+loteprednol include redness in the eyes, blurred vision, burning or stinging sensation in the eye, and eye discomfort. These side effects do not require medical attention and gradually resolve over time.
Please do not use Moxifloxacin+loteprednol without consulting your doctor if you have a damaged cornea, ulcers in the eye, eye infection and producing pus, open lesions in the eye, and glaucoma (a condition where the pressure inside the eye is increased). Inform your doctor if you are pregnant or breastfeeding before using Moxifloxacin+loteprednol. Avoid touching the eyedropper with bare hands or taking it closer to the eyelids while administering drops since it contaminates the dropper tip and solution. If you wear contact lenses, please inform your doctor since the Moxifloxacin+loteprednol may contain additives like Benzalkonium chloride that change the lens's colour. Moxifloxacin+loteprednol sometimes may make your eye red after administration; in such cases, please avoid wearing a lens until the eye improves. Avoid driving or operating machines since the administration of eye drops of Moxifloxacin+loteprednol cause blurred vision for a while after use.
Uses of Moxifloxacin+loteprednol
Medicinal Benefits
Moxifloxacin+loteprednol is a combination of two medicines: Moxifloxacin and Loteprednol. Moxifloxacin is a fluoroquinolone and broad-spectrum antibiotic. It can act against both gram-positive and gram-negative bacteria. It kills bacteria (bactericidal action) by preventing the synthesis of enzymes, namely DNA gyrase and Topoisomerase II and IV, which is essential for the growth and survival of the bacterial cell. Loteprednol is a corticosteroid with anti-inflammatory properties and acts by inhibiting the chemicals such as prostaglandins production (chemical messengers) that make the eye red, swollen, and itchy. It reduces symptoms associated with infection, such as redness and irritation of the eye, and decreases the risk of infections. Collectively, Moxifloxacin+loteprednol treats and prevents bacterial eye infections and eye inflammation caused by allergies, shingles, severe acne, iritis (inflammation of the coloured part of the eye (iris)), uveitis (inflammation of the middle layer of the eye (uvea)), eye injury, radiation, and chemical burns. Moxifloxacin+loteprednol is used to prevent or treat only bacterial eye infections. It does not work against infections caused by viruses and fungi.
Directions for Use
Storage
Side Effects of Moxifloxacin+loteprednol
- Blurred vision
- Burning/stinging sensation in the eyes
- Redness in the eyes
- Watery eyes
- Inflammation of cornea
In-Depth Precautions and Warning
Drug Warnings
Please inform your doctor if you are allergic to Moxifloxacin+loteprednol or any other medicines. Before taking Moxifloxacin+loteprednol, inform your doctor if you have vision problems, severe eye pain, ulcers, glaucoma (raised pressure in the eye), eye injury, or have undergone eye surgery or any other eye drops or eye ointment. If you wear contact lenses, please inform your doctor since Moxifloxacin+loteprednol may contain additives like Benzalkonium chloride that change the lens's colour. Moxifloxacin+loteprednol sometimes may make your eye red after administration; in such cases, please avoid wearing a lens until the eye becomes better. Do not use eye drops for longer than recommended by your doctor, as it may increase the risk of cataracts (clouding of the eye) and increase the risk of a second infection. So, inform your doctor immediately if you notice any persistent visual disturbances while using this medicine. It is advised to check with your doctor before using Moxifloxacin+loteprednol if you are pregnant or breastfeeding. Avoid driving or operating machines since the administration of eye drops of Moxifloxacin+loteprednol cause blurred vision for a while after use.
Drug Interactions
Drug-Drug Interactions: Moxifloxacin+loteprednol may interact with antiviral (ritonavir, cobicistat, amprenavir, atazanavir, boceprevir) painreliver opthalmatic (bromfenac, diclofenac, flurbiprofen) antifungal (itraconazole, fluconazole, posaconazole, voriconazole), and smallpox vaccine.
Drug-Food Interactions: No interaction found.
Drug-Disease Interactions: Moxifloxacin+loteprednol should not be used in patients with fungal eye infections, viral infections such as herpes simplex or varicella, parasitic infections, damaged cornea, and glaucoma (increased pressure inside the eye).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionDo not take alcohol while using Moxifloxacin+loteprednol as it may affect your ability to fight infections.
Pregnancy
cautionInform your doctor before receiving Moxifloxacin+loteprednol if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionLet your doctor know if you are a nursing mother before taking Moxifloxacin+loteprednol; your doctor will decide whether Moxifloxacin+loteprednol can be taken by breastfeeding mothers or not.
Driving
cautionMoxifloxacin+loteprednol may cause side effects like blurry vision, affecting your driving ability. Do not drive or operate machinery in such cases. Drive only when you are alert and have clear vision.
Liver
cautionInform your doctor before receiving the Moxifloxacin+loteprednol if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
cautionInform your doctor before receiving the Moxifloxacin+loteprednol if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.
Children
cautionMoxifloxacin+loteprednol should be used with caution in children. It is not recommended for use in newborns.
Habit Forming
Diet & Lifestyle Advise
- Try to maintain good hygiene to keep your eyes clean and irritant-free.
- Do not rub your eyes even though some ophthalmic drugs make your eye itchy.
- Know your allergy triggers, such as pollen, dust, and other factors.
- Sleep for at least six to eight hours to rejuvenate your eyes naturally.
- Wash your eyes with clean water at least two to three times a day
- Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
- Wash your hands thoroughly, and do not touch the dropper before using drops to avoid contamination.
- Reduce screen time (by avoiding watching tv or phone) and use sunglasses while going into the sunlight.
- Avoid alcoholic beverages as they can make you dehydrated and affect your sleep. This effect can also affect your body’s ability to fight off infections.
Special Advise
- Please consult an eye specialist if your eye infection persists or worsens after using Moxifloxacin+loteprednol for a week.
- Have frequent follow-up check-ups with your doctor to check for any problems such as cataracts, an increase in pressure, or infections if you are using it is prescribed for long-term use.
Patients Concern
Disease/Condition Glossary
Bacterial eye infections: Bacterial eye infections are the common eye problems seen in a primary care setting. The common eye problems are conjunctivitis (inflammation of the conjunctiva), stye (bump on the eyelid), and keratitis (inflammation of the cornea). The risk for eye infection is high in post-operative patients or patients who have undergone Lasik, cataract, or other eye surgeries.
Conjunctivitis: A condition caused by the inflammation and irritation of the eye's mucous membrane (conjunctiva).
FAQs
Moxifloxacin+loteprednol contains Moxifloxacin and Loteprednol. Moxifloxacin is an antibiotic that prevents bacterial cells from dividing and repairing, thereby killing the bacteria. Loteprednol, a corticosteroid, blocks prostaglandins' production (chemical messengers), making the eye red, swollen and itchy. Collectively, Moxifloxacin+loteprednol helps relieve and treat symptoms of bacterial eye infections.
You are not recommended to stop using Moxifloxacin+loteprednol without consulting your doctor even if you feel better, as it may increase pressure in the eyes and may lead to loss of vision. Your symptoms may improve before the infection is completely cured. Therefore, use Moxifloxacin+loteprednol for as long as your doctor has prescribed it, and if you experience any difficulty while taking Moxifloxacin+loteprednol, please consult your doctor.
If you are using other eye drops along with Moxifloxacin+loteprednol, maintain an interval of at least 10 minutes before administering other medicines in the same eye to avoid dilution.
Moxifloxacin+loteprednol is generally prescribed for seven days. You should take this medicine for a duration given by your doctor. Avoid prolonged use, as it may cause cataracts (clouding of the eye) and increase the second infection risk. If you use Moxifloxacin+loteprednol for longer than ten days, you may need frequent vision tests to check the pressure inside your eyes.
Moxifloxacin+loteprednol can cause blurry vision for some time in the beginning. Avoid driving and operating machinery in such cases until you feel better. If the effect persists longer, seek medical attention.
Avoid prolonged use, as it may cause cataracts (clouding of the eye) and increase the risk of a second infection. Also, do not wear contact lenses while using Moxifloxacin+loteprednol.
