Nadroparin
About Nadroparin
Nadroparin belongs to the class of ‘anticoagulants’ (blood thinners), primarily used to prevent and treat harmful blood clots. Nadroparin is also used to prevent stroke or heart attack and deep vein thrombosis (blood clots in leg veins). It reduces the risk of blood clots in patients undergoing larger orthopaedic surgeries like elective hip surgeries. A blood clot can occur in any part of the body, leading to a heart attack, stroke and damage to organs (even coma or death). Blood clots can reach the arteries or veins in the organs like the brain, kidney, heart, lungs and limbs.
Nadroparin contains ‘Nadroparin’ that belongs to the class of low molecular weight heparins (LMWHs). It works by inhibiting the production of clotting factors. This further prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein), thereby preventing blood clot formation. Nadroparin helps in the free flow of blood through your veins, making it less likely to form a serious blood clot.
Nadroparin will be administered by a healthcare professional, do not self-administer. Your doctor will advise the dosage and duration of Nadroparin based on your medical condition. The common side effects of Nadroparin include easy bruising, injection site pain and swelling, mild irritation, weakness, numbness, dizziness, headache, and confusion. Most of these side effects of Nadroparin do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Do not stop taking Nadroparin abruptly since it may worsen your condition and increase the risk of a future heart attack. Let your doctor know if you are allergic to Nadroparin or have kidney/liver diseases and active bleeding issues (like peptic ulcer, brain haemorrhage). Nadroparin is not recommended for use during pregnancy and breastfeeding; however, please seek medical advice. The patient should inform the doctor that they are taking Nadroparin before any surgery is scheduled or any new medicine is taken. Please stay away from activities that may increase your risk of bleeding, like contact sports and using sharp objects like razors and nail cutters.
Uses of Nadroparin
Medicinal Benefits
Nadroparin is composed of Nadroparin, an anticoagulant or a blood thinner. It is low molecular weight heparin and prevents the formation of blood clots by inhibiting the production of clotting factors. It also reduces the risk of blood clots in patients undergoing larger orthopaedic surgeries like elective hip surgeries. Nadroparin helps in the free flow of blood, thereby preventing the risk of heart attack, stroke, deep vein thrombosis (blood clot in the vein), and pulmonary embolism (blood clots in the arteries of lungs). Nadroparin is used to prevent blood clotting in extracorporeal circulation (apparatus carrying the blood outside the body) during haemodialysis (purifying blood in a person whose kidney are abnormally functioning) and hemofiltration (renal replacement therapy) processes.
Directions for Use
Storage
Side Effects of Nadroparin
- Easy bruising
- Injection site pain and swelling
- Mild irritation
- Weakness
- Numbness
- Dizziness
- Headache
- Confusion
Drug Warnings
Before taking Nadroparin, let your doctor know if you have a history of liver and kidney diseases or allergic reactions to Nadroparin. Inform your doctor beforehand if you have a risk of internal bleeding (stomach ulcer), blood disorders (bleeding inside any tissues, organs or joints of your body), a recent injury/surgery or a planned surgery (including dental) in the next few days, a clot in an artery of your brain (ischaemic stroke), eye problems like diabetic retinopathy, spinal problems, artificial heart valves, and high blood pressure. Nadroparin is not recommended for use during pregnancy and breastfeeding; however, please seek medical advice. Try avoiding alcohol to prevent any side effects’ occurrence further. If you experience dizziness, do not drive or operate machinery. Nadroparin is not recommended in people younger than 18 years of age. Store Nadroparin at temperatures not exceeding 25°C.
Drug Interactions
Drug-Drug Interaction: Nadroparin may interact with other blood thinners (clopidogrel, ticlopidine), pain killers, corticosteroids, abortion drugs (mifepristone), and blood pressure medicines (benazepril, captopril).
Drug-Food Interaction: Limit alcohol intake since it may cause a rise in blood pressure leading to heart diseases. Avoid fatty foods and control your cholesterol and triglyceride levels.
Drug-Disease Interaction: Brief your doctor if you have a medical history of heart diseases, active bleeding disorders, ischaemic stroke, diabetic retinopathy, spinal problems, artificial heart valves, high blood pressure, liver, and kidney diseases before taking Nadroparin.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeIt is unsafe to consume alcohol since it may worsen the side effects like dizziness and increase blood pressure.
Pregnancy
cautionNadroparin is not recommended and is probably unsafe to use during pregnancy due to limited information. Please consult your doctor if you are planning to become pregnant or already pregnant before starting Nadroparin.
Breast Feeding
cautionThere is limited data on how Nadroparin affects breastfeeding. However, it is probably unsafe to use and not recommended if you are lactating. Please consult your doctor before starting Nadroparin.
Driving
cautionDo not drive or operate machinery if you experience dizziness or drowsiness while using Nadroparin. Nadroparin can also sometimes cause blurry vision, hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.
Liver
cautionLet your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Nadroparin.
Kidney
cautionLet your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Nadroparin.
Children
unsafeNadroparin is not recommended for children below the age of 18 years. The safety and efficacy of Nadroparin have not been established in children.
Habit Forming
Diet & Lifestyle Advise
- Take the medication as directed by the doctor and at regular intervals. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Nadroparin.
- Avoid vitamin K rich foods such as coriander, cabbage, spinach, broccoli, collard greens, kale (leaf cabbage), black liquorice, turnip greens, avocados, Brussels sprouts as they may decrease the effectiveness of Nadroparin.
- Keep your cholesterol and triglyceride levels under control.
- Eat at regular intervals and maintain a healthy diet that includes fresh fruits and vegetables
- Limit alcohol intake since it raises blood pressure and increases the risk of heart diseases
- Keep a check on your weight and exercise regularly to keep your heart healthy.
- Your doctor also guides you on noticing and managing the early symptoms of detecting heart diseases.
Special Advise
Since Nadroparin may affect liver enzymes, your doctor may suggest liver function tests to check your aspartate aminotransferase (AST), alanine aminotransferase (ALT), and bilirubin levels before starting treatment and every two weeks after the treatment with Nadroparin.
Patients Concern
Disease/Condition Glossary
A blood clot is a clump of blood that has changed from liquid to gel-like or semisolid state. Blood clots are formed to stop bleeding that occurs due to tissue injury. Though blood clots are useful to stop bleeding, they may be harmful when abnormally formed within the blood vessels, restricting the blood flow to essential organs, such as the brain, heart, or lungs, resulting in severe conditions.
Deep vein thrombosis (blood clots in legs) is a medical condition in which blood clots form in deep veins, usually in the legs. The symptoms include leg pain or swelling.
A heart attack occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries). Signs of a heart attack include chest pain, upper body pain, sweating, nausea, fatigue and trouble breathing.
FAQs
Nadroparin contains Nadroparin, an anticoagulant or a blood thinner. It inhibits the production of clotting factors and prevents the formation of blood clots. Thus, Nadroparin reduces the risk of heart attack, stroke, pulmonary embolism, and deep vein thrombosis.
Nadroparin is a blood-thinning agent and can increase the risk of bleeding. It is advised to be cautious during your daily activities like shaving, cutting fingernails or using sharp objects. Also, please consult your doctor beforehand if you undergo any surgery.
Please consult your doctor if Nadroparin needs to be discontinued before undergoing surgery. The doctor might ask you to stop taking Nadroparin a few days before surgery since it can cause an increased risk of bleeding during surgery.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.