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Napafenac

About

Napafenac belongs to the class NSAID's (Non-Steroidal Anti-Inflammatory Drugs). Napafenac is used for the treatment of pain and inflammation associated with cataract surgery. Normally, the lens of your eye is clear but a cataract causes the lens to become cloudy, which eventually affects your vision. So, to treat cataracts a procedure is performed to remove the lens of your eye and replace it with an artificial lens is called cataract surgery. It causes Post-operative risks like pain, inflammation and infection in the eye.

Napafenac contains 'Nepafenac' is a non-steroidal anti-inflammatory drug (NSAID).Napafenac inhibits cyclo-oxygenase (COX) enzymes that further prevents the formation of chemical messengers called 'prostaglandins' (PGs). These prostaglandins are produced at the operated site and cause pain and swelling in the eye. By blocking COX enzymes' effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the operated site/injured or damaged site in the eye.

Napafenac is for external use only. You should take this medicine as prescribed by your doctor. The common side effects of Napafenac include decreased vision, foreign body sensation in the eye, increased intraocular pressure, and watery eyes. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, stop the medicine and consult your doctor immediately.

Before using this medicine, you should tell your doctor about all the other medicines you are taking. You should also tell your doctor if you have any other medical conditions or disorders. Pregnant and breastfeeding women should consult with their doctors before using the medicine. Shake well before using the Napafenac.Always wash your hands before using the Napafenac.Do not touch the tip of the bottle to avoid contamination. Use the Napafenac within four weeks of opening the bottle. Do not drive after its use until your vision is clear.Napafenac can be used with caution in patients with known bleeding tendencies or who are receiving other medications which may prolong bleeding time.Napafenac should not be administered by using a contact lens.

Uses of Napafenac

Post-operative cataract surgery.

Medicinal Benefits

Napafenac is used for the treatment of pain and inflammation associated with cataract surgery.Napafenac contains 'Nepafenac' is a non-steroidal anti-inflammatory drug (NSAID).Napafenac inhibits cyclo-oxygenase (COX) enzymes that further prevents the formation of chemical messengers called 'prostaglandins' (PGs). These prostaglandins are produced at the operated site and cause pain and swelling in the eye. By blocking COX enzymes' effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the operated site/injured or damaged site in the eye.

Directions for Use

Eye drops/Ophthalmic suspension: Lie down and tilt your head backwards. Pull your lower eyelid gently with your index finger to form a pocket. Instil the number of drops as advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Napafenac

  • Decreased vision
  • Foreign body sensation in the eye
  • Increased intraocular pressure
  • Watery eyes.

In-Depth Precautions and Warning

Drug Warnings

Before using this medicine, you should tell your doctor about all the other medicines you are taking. You should also tell your doctor if you have any other medical conditions or disorders. Pregnant and breastfeeding women should consult with their doctors before using the medicine. Shake well before using the Napafenac.Always wash your hands before using the Napafenac.Do not touch the tip of the bottle to avoid contamination. Use the Napafenac within 4 weeks of opening the bottle. Do not drive after its use, until your vision is clear.Napafenac can be used with caution in patients with known bleeding tendencies or who are receiving other medications which may prolong bleeding time.Napafenac should not be administered by using a contact lens.

Drug Interactions

Drug-Drug Interactions: Napafenac may interact with other NSAID'S (nimesulide,metamizole,oxy-phenbutazone), blood-thinners (warfarin),anti-platelets (clopidogrel,aspirin), corticosteroids (prednisone).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Napafenac should not be used in patients with diabetes, an increased risk of bleeding, an ulcer of the cornea of the eye, decreased sensitivity of the cornea of the eye, bleeding in the eye, rheumatoid arthritis, impaired wound healing, a hole developing in the corner of the eye, corneal epithelial degeneration, decrease in normal tears.

Drug-Drug Interactions Checker List:

  • NIMESULIDE
  • OXYPHENBUTAZONE
  • METIMAZOLE
  • CLOPIDOGREL
  • ASPIRIN
  • PREDNISONE
  • WARFARIN
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      Do not take alcohol while using Napafenac as it may affect the effectiveness of your medicine.

    • Safety Warning

      Pregnancy

      caution

      Napafenac is a category C drug. When clinically needed, Napafenac is given to pregnant women after doing a risk/benefit assessment.

    • Safety Warning

      Breast Feeding

      caution

      Napafenac should be used with caution in breastfeeding mothers

    • Safety Warning

      Driving

      caution

      Napafenac may cause vision problems. So, avoid driving until your vision clears.

    • Safety Warning

      Liver

      safe if prescribed

      Napafenac should be used in liver patients, please consult your doctor if any concerns.

    • Safety Warning

      Kidney

      safe if prescribed

      Napafenac should be used in kidney patients, please consult your doctor if any concerns.

    • Safety Warning

      Children

      caution

      Napafenac should not be used below the age of 10 years.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Don't do any strenuous activities for a few weeks. Avoid rigorous exercise and heavy lifting.
    • Don't drive. 
    • Follow your doctor's orders regarding any antibiotic and anti-inflammatory eye drops. ...
    • Stay away from dusty areas.
    • Don't rub your eye.
    • Don't swim.
    • Don't wear make-up.
    • Eat leafy greens, sweet potatoes and carrots as well as citrus fruits, sweet bell peppers and tomatoes.

    Special Advise

    If you are using other eye drops along with Napafenac, maintain an interval of at least 5 minutes before administering other medicines in the same eye to avoid dilution.

    Patients Concern

    Disease/Condition Glossary

    Cataract surgery is performed to treat cataracts. Normally, the lens of your eye is clear, but a cataract causes the lens to become cloudy, which eventually affects your vision. So, to treat cataracts, a procedure is performed to remove the lens of your eye and replace it with an artificial lens is called cataract surgery. It causes Post-operative risks like pain, inflammation and infection in the eye. 

    FAQs

    Napafenac inhibits cyclo-oxygenase (COX) enzymes that further prevents the formation of chemical messengers called 'prostaglandins' (PGs). These prostaglandins are produced at the operated site and cause pain and swelling in the eye. By blocking COX enzymes' effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the operated site/injured or damaged site in the eye.

    Napafenac is used to prevent and treat pain and swelling that occurs after cataract surgery.

    No,Napafenac cannot be administered with a contact lens. Because it does not allow the medicine into the eye.

    Napafenac cannot be stopped suddenly. It should be done as advised by your doctor.

    common side effects of Napafenac include decreased vision, foreign body sensation in the eye, increased intraocular pressure, watery eyes. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, stop the medicine and consult your doctor immediately.

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    Napafenac

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