Olmesartan Medoxomil+indapamide
About
Olmesartan Medoxomil+indapamide is a combination of blood pressure-lowering medicine (Olmesartan Medoxomil) and water pills or diuretics (Indapamide) primarily used to treat high blood pressure. Hypertension or high blood pressure is a chronic condition in which the force exerted by the blood against the artery wall increases. As a result, it leads to heart disease, irregular heartbeat, and other complications.
Olmesartan Medoxomil+indapamide is a combination of two medicines: Olmesartan Medoxomil and Indapamide. Olmesartan is an angiotensin receptor blocker (ARB) that works by blocking the hormone angiotensin, thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Indapamide is a diuretic or water pill that removes extra water and certain electrolytes from the body. Together it lowers fluid overload and blood pressure and improves blood flow.
You can take Olmesartan Medoxomil+indapamide with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on how often you take your tablets based on your medical condition. In some cases, you may experience headaches, nausea, or dizziness. Most of these side effects of Olmesartan Medoxomil+indapamide do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and can increase the risk of heart disease and stroke. Inform your doctor if you are suffering from kidney, liver, heart disease, or diabetes. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Olmesartan Medoxomil+indapamide can be prescribed accordingly. Do not use the Olmesartan Medoxomil+indapamide if you cannot urinate, are dehydrated, have low blood pressure (hypotension), or have a cardiogenic shock (sudden stopping blood flow to the heart). Please tell your doctor if you are taking any other medicines or are allergic to this medicine. Reducing the amount of table salt (sodium chloride) in your food often relieves the swelling of the body.
Uses of Olmesartan Medoxomil+indapamide
Medicinal Benefits
Olmesartan Medoxomil+indapamide is a combination medication, generally used when a single medicine is ineffective in controlling blood pressure. Olmesartan Medoxomil+indapamide is used to treat hypertension, whereas Olmesartan Medoxomil works by relaxing the blood vessels. On the other hand, Indapamide, a diuretic, works by increasing the amount of urine passed out from the kidneys, lowering blood pressure. Together it lowers the overall raised blood pressure and reduces the risk of heart attack, stroke, or kidney problems.
Directions for Use
Storage
Side Effects of Olmesartan Medoxomil+indapamide
- Bradycardia (slow heart rate)
- Cold extremities
- Drowsiness
- Gastrointestinal disturbances
- Nausea
- Fatigue
In-Depth Precautions and Warning
Drug Warnings
It is recommended not to use if you are allergic to any component present in the Olmesartan Medoxomil+indapamide. Inform your doctor if you have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, or liver disease, are pregnant women, or planning to get pregnant and breastfeed women. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Olmesartan Medoxomil+indapamide can pass into breast milk, but its effect on the baby is unknown. So, it is better to tell your doctor if you take Olmesartan Medoxomil+indapamide and breastfeeding.
Drug Interactions
Drug-Drug Interactions: Olmesartan Medoxomil+indapamide may interact with other high blood pressure-lowering pills (benazepril, metoprolol, ramipril, hydrochlorothiazide, simvastatin, diltiazem, verapamil, azilsartan, benazepril, lisinopril, amiloride), medicines used to treat erectile dysfunction (sildenafil), antibiotics (clarithromycin, erythromycin, rifampicin), antifungal (itraconazole, ketoconazole), anti-HIV drugs (ritonavir), anti-epilepsy medicines (carbamazepine, phenytoin, phenobarbital, primidone), immune-suppressing drugs (cyclosporine, tacrolimus), and pain killers (ibuprofen, aspirin).
Drug-Food Interactions: Olmesartan Medoxomil+indapamide severely interacts with grapefruit, grapefruit juices, and St. John’s wort (a plant used to treat depression). Hence it should not be taken with Olmesartan Medoxomil+indapamide.
Drug-Disease Interactions: Olmesartan Medoxomil+indapamide should not be given to people with cardiogenic shock (when the heart fails to pump required blood to the body), heart valve problem (stenosis), low blood pressure (hypotension), coronary heart disease, liver disease, renal impairment, or heart failure.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionYou are recommended not to consume alcohol along with Olmesartan Medoxomil+indapamide to avoid unpleasant side-effects.
Pregnancy
cautionOlmesartan Medoxomil+indapamide is recommended to use during pregnancy. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast Feeding
cautionLet your doctor know if you are a nursing mother before taking Olmesartan Medoxomil+indapamide; your doctor will decide whether Olmesartan Medoxomil+indapamide can be taken by breastfeeding mothers or not.
Driving
cautionDriving after taking Olmesartan Medoxomil+indapamide is not recommended as it may occasionally cause drowsiness or fatigue.
Liver
cautionOlmesartan Medoxomil+indapamide to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
Kidney
cautionOlmesartan Medoxomil+indapamide to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.
Children
unsafeUse of Olmesartan Medoxomil+indapamide in children less than 1 year of age is not recommended as the safety and efficacy of Olmesartan Medoxomil+indapamide in these age groups have not yet been established.
Habit Forming
Diet & Lifestyle Advise
- Keep your weight under control with a BMI of 19.5-24.9.
- Regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the
- week. Doing this can help lower your raised blood pressure by about 5 mm Hg.
- Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
- Limit sodium chloride (table salt) intake in your daily diet to 2300 mg per day or less than 1500 mg is ideal for
- most adults.
- If you are taking alcohol, then only one serving for women and two servings for men is advisable.
- Quitting smoking is the best strategy to lower the risk of heart disease.
- Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope
- with stress and practice mindfulness techniques.
- Monitor your blood pressure daily and if there is too much fluctuation, immediately contact your doctor.
- Try to include heart-healthy omega-3 fatty acids-containing food drinks in your daily diet. You can also use low-fat
- cooking oil like olive oil, soybean oil, canola oil, and coconut oil can help lower your elevated blood pressure.
Patients Concern
Disease/Condition Glossary
Hypertension: The blood exerts increased pressure on the walls of blood vessels leading to hypertension. High blood pressure is expressed as systolic/diastolic pressure. Systolic pressure is the pressure in the arteries when the heart beats or pumps out blood. Diastolic pressure is the pressure in the arteries between the heartbeats. Blood pressure is measured in millimetres of mercury (mmHg) by a blood pressure monitor called a sphygmomanometer. Some of the symptoms are headache, dizziness, nosebleeds, altered vision, chest pain, weakness, and shortness of breath. However, most of the time, the signs and symptoms of hypertension are none.
FAQs
Usually, Olmesartan Medoxomil+indapamide is safe to prescribe to elderly patients as no overall difference in safety and efficacy of the medicine is found.
Olmesartan Medoxomil+indapamide should only be taken if prescribed by the doctor as they may advise this medicine after checking all the medical conditions of the patient. If required they will adjust the dosage.
Certain factors can cause high blood pressure, like obesity, age, genetics, inactivity and poor diet.
There are several serious health conditions associated with high blood pressure including Atherosclerosis (buildup of or fatty material inside walls of the blood vessels), Heart Disease, Kidney Disease, and Eye Disease. Thus, itis important to maintain normal blood pressure to avoid such risks.
Blood pressure is the physical force exerted by blood against the blood vessels. Each time the heart beats, the heart pumps blood into arteries.
Blood pressure changes up and down depending on your activities, as blood pressure becomes high during exercise. Even blood pressure is high during the day than at night. Bloodpressureincreasewith age particularly tends to go up as we grow old.
Hypertension or high blood pressure is a lifelong disease that can be managed effectively with treatment withOlmesartan Medoxomil+indapamide, and make some modifications in lifestyle. However, if treatment is stopped, it will return reasonably quickly.
Taking Olmesartan Medoxomil+indapamide may cause dehydration. So, to avoid dehydration, drink plenty of fluids, and inform your doctor if you feel extremely thirsty.
It's unlikely that Olmesartan Medoxomil+indapamide affects fertility in men or women. However, some water pills like hydrochlorothiazide may lead to erectile dysfunction. There's not enough evidence to say for certain. For the best advice, consult your doctor.
Try not to skip a dose in the first place. However, if you have missed a dose of Olmesartan Medoxomil+indapamide, you are advised to take it as soon as you remember. If it's time for you to take your next dose, then do not take both doses together. Take only one dose. Taking a double dose of Olmesartan Medoxomil+indapamide will lead to low blood pressure.
Olmesartan Medoxomil+indapamide can be safely taken as long as your doctor prescribes it. Conditions such as high blood pressure are life-long conditions, and one should not abruptly discontinue it without discussing it with a doctor.
You are advised not to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend discontinuing it.
