Olmesartan+cilnidipine+chlorthalidone
About
Olmesartan+cilnidipine+chlorthalidone belongs to a group of medications called 'anti-hypertensives primarily used to treat high blood pressure (hypertension). High blood pressure is a chronic (long-term) condition in which blood pressure is elevated persistently in higher than normal levels. This condition can also cause fluid retention, leading to peripheral oedema (swelling of legs and hands). If left untreated, this condition can increase the risk of heart-related diseases like heart attack, heart failure, stroke, irregular heartbeat, and other complications.
Olmesartan+cilnidipine+chlorthalidone contains Olmesartan, Cilnidipine, and Chlorthalidone. Olmesartan is an angiotensin-II receptor blocker (ARB). Angiotensin narrows the blood vessels increasing the blood pressure, therefore blocking angiotensin can result in widening of the narrowed blood vessels. Cilnidipine is a calcium channel blocker. It acts by relaxing the blood vessels and improving the blood flow. Chlorthalidone is a diuretic or water pill that acts by expelling excess water and salt from the body. It helps in decreasing fluid accumulation and oedema (fluid overload).
You should take this medicine exactly as prescribed by the doctor. The common side-effects of Olmesartan+cilnidipine+chlorthalidone are dizziness, low blood pressure, flushing (reddening of the skin, especially face), headache, palpitations (pounding heartbeat), increased micturition (frequency of urination), and lethargy (feeling weak). These side-effects usually resolve without requiring any medical attention. However, if any of these side-effects persist or get worse, inform your doctor immediately.
It is not recommended to take Olmesartan+cilnidipine+chlorthalidone if you are allergic to any contents of it. It is not advised to take Olmesartan+cilnidipine+chlorthalidone if you are allergic to sulfa drugs, unable to urinate, taking aliskiren, and have diabetes or kidney disease. It is not recommended for use in children, pregnant women, and breastfeeding mothers. It should be used with caution in elderly people. Alcohol consumption may increase the risk of side-effects. Olmesartan+cilnidipine+chlorthalidone may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.
Uses of Olmesartan+cilnidipine+chlorthalidone
Medicinal Benefits
Olmesartan+cilnidipine+chlorthalidone is used to treat hypertension (high blood pressure) in adults. It works by lowering the body’s production of substances that could increase heart rate and also widens narrowed blood vessels. It allows the blood to flow more smoothly in the blood vessels. It also helps to reduce oedema or fluid overload. Olmesartan+cilnidipine+chlorthalidone is a combination of medicines, so it shows greater efficacy and tolerability when compared to monotherapies. It helps to reduce serious complications of hypertension such as heart attack, stroke, and end-stage kidney disease.
Directions for Use
Storage
Side Effects of Olmesartan+cilnidipine+chlorthalidone
- Dizziness
- Low blood pressure
- Flushing (reddening of the skin, especially face)
- Headache
- Palpitations (pounding heartbeat)
- Increased micturition (frequency of urination)
- Lethargy (feeling weak)
In-Depth Precautions and Warning
Drug Warnings
Before taking Olmesartan+cilnidipine+chlorthalidone, inform your doctor if you have liver or kidney disease, heart failure, are on a low-salt diet, gout, high cholesterol, diabetes, and severe hypotension (low blood pressure). Do not get overheated in hot weather or by doing heavy exercise. Make sure to get hydrated by drinking fluids in these conditions. Olmesartan+cilnidipine+chlorthalidone may cause imbalances in the electrolyte levels. Olmesartan+cilnidipine+chlorthalidone may cause low blood pressure, so inform your doctor if you experience vomiting, diarrhoea, or excessive sweating.
Drug Interactions
Drug-Drug Interactions: Olmesartan+cilnidipine+chlorthalidone may interact with other blood pressure medicines, medicines used to treat heart disease (digoxin and quinidine), antidiabetic medicine (insulin), oral diabetes medicines, steroid medicines, anti-psychotic drugs, antibiotics (rifampicin and erythromycin), and medicine used to treat fits (phenytoin).
Drug-Food Interactions: No interactions found.
Drug-Disease Interactions: Olmesartan+cilnidipine+chlorthalidone should be used with caution in patients with liver or kidney disease, heart failure, are on a low-salt diet, gout, high cholesterol, diabetes, and severe hypotension (low blood pressure).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAlcohol should not be taken while using Olmesartan+cilnidipine+chlorthalidone. It may worsen the health condition by increasing the risk of side-effects.
Pregnancy
unsafeOlmesartan+cilnidipine+chlorthalidone is a category C medicine and may cause harmful effects to the fetus or unborn baby. So, it is not recommended for use in pregnant women.
Breast Feeding
cautionOlmesartan+cilnidipine+chlorthalidone should be used with caution in breastfeeding mothers. Please consult your doctor before use.
Driving
cautionOlmesartan+cilnidipine+chlorthalidone may cause dizziness and affect your ability to drive. So, do not drive or operate heavy machinery if you feel dizzy.
Liver
cautionOlmesartan+cilnidipine+chlorthalidone should be used with caution in patients with liver diseases. The dose may have to be adjusted by the doctor as required.
Kidney
cautionOlmesartan+cilnidipine+chlorthalidone should be used with extreme caution in patients with kidney diseases. The dose may have to be adjusted by the doctor as required.
Children
unsafeOlmesartan+cilnidipine+chlorthalidone is not recommended for use in children below 12 years of age.
Habit Forming
Diet & Lifestyle Advise
- Keep your weight under control with a body mass index (BMI) 19.5-24.9.
- Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
- Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
- Limit alcohol intake. One serving for women and two servings for men is advisable.
- Quit smoking as it is the best strategy to lower the risk of heart disease.
- Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
- Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
- Try to include heart-healthy omega 3 fatty acids-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.
Special Advise
- Your doctor may monitor kidney function, blood pressure, and electrolyte levels at regular intervals while using Olmesartan+cilnidipine+chlorthalidone.
- Olmesartan+cilnidipine+chlorthalidone may cause orthostatic hypotension (sudden drop in blood pressure on standing), so rise slowly while standing up from a sitting or lying position.
- Do not stop taking this medicine even if you feel better unless advised by the doctor.
Patients Concern
Disease/Condition Glossary
Hypertension: It is a chronic (long-term) condition in which blood pressure is elevated persistently at higher than normal levels. It occurs when the blood’s force against the wall of blood vessels is too high. This condition can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes damage to the brain, kidneys, and eyes. The risk of high blood pressure complications increases with the following: obesity, smoking, diabetes, alcohol intake, lack of physical inactivity, stress, and kidney diseases.
FAQs
Olmesartan+cilnidipine+chlorthalidone reduces elevated blood pressure. It contains Olmesartan, Cilnidipine, and Chlorthalidone. Olmesartan is an angiotensin-II receptor blocker (ARB). Angiotensin narrows the blood vessels increasing the blood pressure, therefore blocking angiotensin can result in widening of the narrowed blood vessels. Cilnidipine is a calcium channel blocker. It acts by relaxing the blood vessels and improving the blood flow. Chlorthalidone is a diuretic or water pill that acts by expelling excess water and salt from the body. It helps in decreasing fluid accumulation and oedema (fluid overload).
Olmesartan+cilnidipine+chlorthalidone may cause low blood pressure resulting in dizziness or fainting. It may also cause orthostatic hypotension (sudden drop in blood pressure while standing up), so rise slowly while standing up from a sitting or lying position.
You should not discontinue using Olmesartan+cilnidipine+chlorthalidone without consulting your doctor. The doctor may monitor your blood pressure for at least two weeks before reducing the dose and gradually stopping the medicine.
The common side-effects of Olmesartan+cilnidipine+chlorthalidone are dizziness, low blood pressure, flushing (reddening of the skin, especially face), headache, palpitations (pounding heartbeat), increased micturition (frequency of urination), and lethargy (feeling weak). These side-effects are usually mild and resolve without requiring any medical attention. However, if any of these side-effects persist or get worse, inform your doctor immediately.
Please inform your doctor before surgery if you are taking Olmesartan+cilnidipine+chlorthalidone as it needs to be stopped because it might lower the blood pressure further if taken along with general anaesthesia.
