Omeprazole+domperidone
About
Omeprazole+domperidone belongs to a group of medicines called gastrointestinal agents used to treat heartburn, indigestion, epigastric pain, gastro-oesophageal reflux disease (GERD), peptic ulcers and Zollinger-Ellison syndrome. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach. Zollinger-Ellison syndrome is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production.
Omeprazole+domperidone is a combination of two drugs, namely: Omeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Omeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid Domperidone works by increasing the movements and contractions of stomach muscle. Together, Omeprazole+domperidone helps in treating acidity.
Take Omeprazole+domperidone 30-60minutes prior to food. Swallow Omeprazole+domperidone as a whole with a glass of water; do not chew, or break it. You are advised to take Omeprazole+domperidone for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Inform your doctor if you have a history of gastrointestinal bleeding or intestinal obstruction. Consult your doctor before taking Omeprazole+domperidone if you are pregnant or breastfeeding. Omeprazole+domperidone may cause sleepiness, so drive only if you are alert. Omeprazole+domperidone should not be given to children as safety has not been established. Avoid consuming alcohol along with Omeprazole+domperidone as it could lead to increased drowsiness and can elevate the production of stomach acid.
Uses of Omeprazole+domperidone
Medicinal Benefits
Omeprazole+domperidone belongs to a group of medicines called gastrointestinal agents used to treat heartburn, indigestion, epigastric pain, gastro-oesophageal reflux disease (GERD), peptic ulcers and Zollinger-Ellison syndrome. Omeprazole+domperidone is a combination of two drugs, namely: Omeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Omeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid Domperidone works by increasing the movements and contractions of stomach muscle. Together, Omeprazole+domperidone helps in treating acidity.
Directions for Use
Storage
Side Effects of Omeprazole+domperidone
- Dry mouth
- Stomach pain
- Diarrhoea
- Headache
- Flatulence
In-Depth Precautions and Warning
Drug Warnings
Do not take Omeprazole+domperidone if you are allergic to any of its contents; if you are taking nelfinavir (anti-HIV); if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment. Inform your doctor before taking Omeprazole+domperidone if you have severe liver or kidney problems; if you are due to have Chromogranin A test; if you experience unexplained weight loss, stomach pain, indigestion, vomit food or blood, or if you pass black stools. Talk to your doctor before taking Omeprazole+domperidone if you have osteoporosis as Omeprazole+domperidone may increase the risk of bone fractures on long-term treatment. Consult your doctor before taking Omeprazole+domperidone if you are pregnant or breastfeeding. Omeprazole+domperidone may cause sleepiness, so drive only if you are alert. Omeprazole+domperidone should not be given to children as safety has not been established. Avoid consuming alcohol along with Omeprazole+domperidone as it could lead to increased drowsiness and can elevate the production of stomach acid.
Drug Interactions
Drug-Drug Interactions: Omeprazole+domperidone may interact with painkillers (aspirin), antibiotics (ciprofloxacin), statin (atorvastatin), anti-HIV (atazanavir), blood thinner (clopidogrel, warfarin, cilostazol), a drug used to treat hypothyroidism (levothyroxine), anti-fungal (ketoconazole, itraconazole, voriconazole), anti-cancer (erlotinib, methotrexate), anti-depressant (citalopram, escitalopram, duloxetine), anti-anxiety (alprazolam), vitamin (cyanocobalamin), anti-convulsant (phenytoin), gastroprokinetic agent (cisapride), cardiac glycoside (digoxin), immunosuppressant (tacrolimus), anti-tuberculosis (rifampicin).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interaction: Inform your doctor if you have epilepsy, mania, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, or hypomagnesemia (low levels of magnesium).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Omeprazole+domperidone. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Pregnancy
cautionConsult your doctor before taking Omeprazole+domperidone if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionOmeprazole+domperidone may pass into breast milk. Consult your doctor before taking Omeprazole+domperidone; your doctor will decide whether Omeprazole+domperidone can be taken by breastfeeding mothers or not.
Driving
cautionOmeprazole+domperidone may cause sleepiness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor before taking Omeprazole+domperidone if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Omeprazole+domperidone if you have kidney impairment or any concerns regarding this.
Children
unsafeOmeprazole+domperidone should not be given to children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating as it causes acid reflux.
- Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
- Practise relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.
Special Advise
- Inform your doctor before taking Omeprazole+domperidone if you are due to have Chromogranin A test.
- Omeprazole+domperidone may cause changes in a blood test to check liver functioning. Inform the person doing the tests that you are taking Omeprazole+domperidone.
- Talk to your doctor before taking Omeprazole+domperidone if you have osteoporosis as Omeprazole+domperidone may increase the risk of bone fractures on long-term treatment.
Patients Concern
Disease/Condition Glossary
Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers: Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of the stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion
Zollinger-Ellison syndrome: It is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting.
FAQs
Omeprazole+domperidone contains Omeprazole and Domperidone. Omeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of stomach muscles. Together, Omeprazole+domperidone helps in treating acidity.
Diarrhoea might be a side-effect of Omeprazole+domperidone. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you experience severe diarrhoea or if you find blood in your stools.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Dry mouth could be a side-effect of Omeprazole+domperidone. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Omeprazole+domperidone contains domperidone which helps in treating nausea and vomiting. However, Omeprazole+domperidone is used to treat acidity. Please consult your doctor, he/she may prescribe you an alternate medicine for treating nausea and vomiting.
Do not take Omeprazole+domperidone for longer durations unless prescribed by the doctor. Consult your doctor if your condition does not improve even after taking Omeprazole+domperidone for 14days.
