Pantoprazole+amoxicillin+clarithromycin
About
Pantoprazole+amoxicillin+clarithromycin belongs to a group of medicines called gastrointestinal agents which is used in the treatment of peptic ulcer disease caused by infection with a common type of bacteria called Helicobacter pylori (H. pylori). Peptic ulcers are sores (small, shallow wounds) that develop on the intestine and stomach's inner lining.
Pantoprazole+amoxicillin+clarithromycin is a combination of three drugs, namely: Pantoprazole, amoxicillin, and clarithromycin. Amoxicillin is bactericidal (kills bacteria) that works by preventing the formation of bacterial cell covering (protective cell wall) necessary for their survival, thereby preventing the growth of bacteria. Clarithromycin is a bacteriostatic antibiotic i.e., it stops the growth of bacteria but necessarily does not kill them. It works by inhibiting the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Pantoprazole is a proton pump inhibitor that works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid in the stomach. Thereby, reduces the amount of acid produced in the stomach. Altogether, Pantoprazole+amoxicillin+clarithromycin helps in the treatment of peptic ulcer disease.
You are advised to take Pantoprazole+amoxicillin+clarithromycin for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, diarrhea, vomiting, stomach pain, taste change, headache. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Inform your doctor before taking Pantoprazole+amoxicillin+clarithromycin if you have a history of liver disease, kidney disease, myasthenia gravis (neuromuscular disease). Do not take Pantoprazole+amoxicillin+clarithromycin if you are pregnant or breastfeeding unless prescribed by the doctor. Pantoprazole+amoxicillin+clarithromycin causes drowsiness, so drive only if you are alert. Pantoprazole+amoxicillin+clarithromycin should not be given to children as safety has not been established. Avoid consuming alcohol along with Pantoprazole+amoxicillin+clarithromycin as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side-effects.
Uses of Pantoprazole+amoxicillin+clarithromycin
Medicinal Benefits
Pantoprazole+amoxicillin+clarithromycin is a combination of three drugs, namely: Pantoprazole, amoxicillin, and clarithromycin. Amoxicillin is bactericidal (kills bacteria) that works by preventing the formation of bacterial cell covering (protective cell wall) necessary for their survival, thereby preventing the growth of bacteria. Clarithromycin is a bacteriostatic antibiotic i.e., it stops the growth of bacteria but necessarily does not kill them. It works by inhibiting the protein synthesis process required for the growth of the bacterial cell. As a result, bacterial cells are not able to reproduce and grow. Pantoprazole is a proton pump inhibitor that works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid in the stomach. Thereby, reduces the amount of acid produced in the stomach. Altogether, Pantoprazole+amoxicillin+clarithromycin helps in the treatment of peptic ulcer disease.
Directions for Use
Storage
Side Effects of Pantoprazole+amoxicillin+clarithromycin
- Upset stomach or throwing up
- Diarrhoea
- Headache
- Bad taste in your mouth
- Belly pain
- Headache
- Rash
In-Depth Precautions and Warning
Drug Warnings
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes break every hour by doing brisk walking or stretching.
Drug Interactions
DRUG-DRUG INTERACTIONS: Pantoprazole+amoxicillin+clarithromycin may have interaction with medicines used to treat HIV (such as atazanavir, saquinavir, zidovudine), medicines used to treat fungal infections (such as fluconazole), medicines used to treat bacterial infections (such as itraconazole), medicines used to lower cholesterol level (such as atorvastatin), medicines help to stop blood clots (such as warfarin), and vitamin (vitamin b12).
FOOD-DRUG INTERACTIONS: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
DRUG-DISEASE INTERACTION: Pantoprazole+amoxicillin+clarithromycin may have interactions with gastrointestinal bleeding, diabetes, myasthenia gravis (neuromuscular disease), liver disease, bone fractures, hypomagnesemia (low levels of magnesium), and liver disease.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Pantoprazole+amoxicillin+clarithromycin. Alcohol intake leads to increased production of stomach acid.
Pregnancy
cautionConsult your doctor before taking Pantoprazole+amoxicillin+clarithromycin if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor before taking Pantoprazole+amoxicillin+clarithromycin, your doctor will decide whether Pantoprazole+amoxicillin+clarithromycin can be taken by breastfeeding mothers or not.
Driving
cautionPantoprazole+amoxicillin+clarithromycin causes dizziness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor before taking Pantoprazole+amoxicillin+clarithromycin if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Pantoprazole+amoxicillin+clarithromycin if you have kidney impairment or any concerns regarding this.
Children
unsafePantoprazole+amoxicillin+clarithromycin should not be given to children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
- Avoid tight-fitting clothes.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes break every hour by doing brisk walking or stretching.
Special Advise
- Take Pantoprazole+amoxicillin+clarithromycin 1-hour prior food.
- Do not stop taking Pantoprazole+amoxicillin+clarithromycin on your own. Stopping abruptly might cause the symptoms to reappear and will make the infection difficult to treat due to antibiotic resistance.
- Make sure you drink plenty of fluids when you are sick. This will, in general help you clear out the infection faster, protect you from dehydration.
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If you feel nauseous after taking Pantoprazole+amoxicillin+clarithromycin, stick to simple meals like khichdi, dal roti and other home-cooked meals. Avoid spicy and fatty food.
Patients Concern
Disease/Condition Glossary
Peptic ulcers: Peptic ulcers are sores (small, shallow wounds) that develop on the lining of the stomach and intestine due to erosion of the stomach protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion-like pain. The indigestion-like pain can be brief or may last for hours, one may experience more severe pain when the stomach is empty or right after eating. If the ulcer is untreated, then it may lead to several complications such as internal bleeding, peritonitis (ulcer bores a hole through the wall of the stomach or small intestine), and it may also cause pyloric stenosis (chronic inflammation in the lining of the stomach or duodenum). Taking prescribed medicines like Pantoprazole+amoxicillin+clarithromycin helps to relieve symptoms associated with peptic ulcer disease.
FAQs
Speak to your doctor if you do not feel better even after taking Pantoprazole+amoxicillin+clarithromycin for 14 days. Do not take Pantoprazole+amoxicillin+clarithromycin for longer durations unless prescribed by the doctor.
Pantoprazole+amoxicillin+clarithromycin may causes dizziness. Drive only if you are alert and omit driving and operating machinery if you feel dizzy after taking Pantoprazole+amoxicillin+clarithromycin.
Avoid or limit the consumption of alcohol while on Pantoprazole+amoxicillin+clarithromycin as it may lead to increased dizziness. Alcohol intake may also lead to excess production of stomach acid, thereby increases acidity and heartburn.
Diarrhoea might be a side-effect of Pantoprazole+amoxicillin+clarithromycin. Drink enough fluids and eat fibre rich food if you experience diarrhoea after taking Pantoprazole+amoxicillin+clarithromycin. If you find blood in stools (tarry stools) or if you experience excess diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Pantoprazole+amoxicillin+clarithromycin contains pantoprazole which may increase the risk of bone fracture in the hip, spine or wrist. This is because, recent clinical studies indicated that pantoprazole may affect the absorption of certain nutrients and minerals that are required for maintaining good bone health, so as a result, it can lead to fractures. This mainly occurs in people taking higher doses of Pantoprazole+amoxicillin+clarithromycin for longer durations. Inform your doctor before taking Pantoprazole+amoxicillin+clarithromycin if you have osteoporosis or if you are already taking corticosteroids.
Dry mouth could be a side-effect of Pantoprazole+amoxicillin+clarithromycin. Limiting caffeine intake, avoiding smoking, drinking enough water, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents dryness of the mouth.
