Pantoprazole+domperidone
About
Pantoprazole+domperidone is composed of two medicines, namely: Domperidone and Pantoprazole. Domperidone is a prokinetic and anti-nausea agent that helps to treat indigestion and stomach pain. On the other hand, Pantoprazole is a proton pump inhibitor that reduces the excess stomach acid formation by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). Pantoprazole+domperidone is a widely used medicine to treat peptic ulcers and gastroesophageal reflux disease (GERD). Pantoprazole+domperidone prevents the release of stomach acid and relieves symptoms of food pipe lining inflammation (esophagitis), and gastroesophageal reflux disease (GERD), or heartburn.
Domperidone works by increasing the movement of food through the stomach and the digestive tract more quickly and in this way reduces the feeling of bloating, or fullness and indigestion. On the other hand, it effectively blocks the action of a vomiting centre (chemoreceptor trigger zone - CTZ) located in your brain, that is responsible for inducing the feeling of nausea and vomiting. Pantoprazole helps in reducing the stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This proton pump lies in the cells of the stomach wall responsible for the release of gastric acid secretion damaging tissues in the food pipe, stomach, and duodenum.
It should be taken as prescribed by the doctor. Like all medicines, Pantoprazole+domperidone may cause side effects, although not everybody gets them. The most common side effects of Pantoprazole+domperidone are diarrhoea, stomach pain, flatulence (gas), dryness in the mouth, dizziness, and headache. Everyone doesn't need to experience the above side effects. In case of any discomfort, speak with your doctor.
It is recommended not to use if you are allergic to any ingredinets present in it. Prolonged intake of Pantoprazole is associated with a low level of Vitamin B12 and low magnesium. Hence yearly test of Vitamin B12 and magnesium is required if you are taking Pantoprazole+domperidone for the long term. Use of Pantoprazole+domperidone is contraindicated in people with lupus (autoimmune inflammatory disease). Try to avoid caffeine-containing beverages (coffee, tea), spicy/deep fried/processed foods, carbonated drinks, acidic foods like citrus fruits/vegetables (tomatoes).
Uses of Pantoprazole+domperidone
Medicinal Benefits
Pantoprazole+domperidone plays a vital role in preventing nausea, vomiting, stomach upset, stomach pain, peptic ulcer, and other conditions due to hyperacidity or acid reflux. Pantoprazole prevents the proton pumps gate from producing an excessive amount of stomach acid. While Domperidone stops nausea (feeling sick) and vomiting (being sick) blocking messages between parts of your brain called the chemoreceptor trigger zone (CTZ) and the vomiting centre.
Directions for Use
Side Effects of Pantoprazole+domperidone
- Headache
- Diarrhoea
- Nausea
- Abdominal pain
- Vomiting
- Flatulence
- Dizziness
- Arthralgia (joint pain)
In-Depth Precautions and Warning
Drug Warnings
You should avoid taking Pantoprazole+domperidone if you are allergic to Pantoprazole+domperidone or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, pregnant or planning for pregnancy, and breastfeeding mothers. Pantoprazole+domperidone may interact with a blood thinner (warfarin), antifungal (ketoconazole), anti-HIV drug (atazanavir, nelfinavir), iron supplements, ampicillin antibiotic, anti-cancer drug (methotrexate). Let your doctor know if you are taking these medicines. Prolonged intake of Pantoprazole+domperidone may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its own tissues), Vitamin B12, and magnesium deficiency. Intake of Pantoprazole+domperidone may mask the symptom of gastric cancer, so if you have any severe stomach pain or gastric bleeding (blood in mucous or stool) immediately consult the doctor.
Drug Interactions
Drug-Drug Interactions: Pantoprazole+domperidone may interact with a blood thinner (e.g. clopidogrel, warfarin), antifungal (e.g. ketoconazole, voriconazole, itraconazole, posaconazole), anti-HIV drug (e.g. atazanavir, nelfinavir), iron supplements, antibiotic (e.g. ampicillin, rifampicin), heart medicine (e.g. digoxin) and anti-cancer drug (e.g. methotrexate). Let your doctor know if you are taking these medicines.
Drug-Food Interactions: Pantoprazole+domperidone interact with St John's wort plant that is used as an anti-depressant. This plant may affect the working of Pantoprazole+domperidone. So avoid its intake with Pantoprazole+domperidone.
Drug-Disease Interactions: Pantoprazole+domperidone should be not given in patients with C. difficile induced colitis, liver disease, bone fractures, low Vitamin B12 (anaemia), low magnesium (hypomagnesemia).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is best to avoid alcohol while taking medication.
Pregnancy
cautionIf you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. You should use this medicine only if your doctor considers the benefit for you greater than the potential risk for your unborn child or baby.
Breast Feeding
cautionPantoprazole+domperidone should be used in breastfeeding mothers only if the benefits outweigh the risks.
Driving
cautionDrive only if you are physically stable and mentally focussed, If you experience drowsiness after taking Pantoprazole+domperidone you should not drive or operate any machinery or vehicles.
Liver
cautionIn patients with severe liver impairment, the liver enzymes should be monitored regularly during treatment with pantoprazole, particularly on long-term use
Kidney
cautionInform your doctor before receiving the Pantoprazole+domperidone if you have a kidney impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.
Children
safe if prescribedPantoprazole+domperidone can be given safely to children provided; dose has been prescribed by a child specialist.
Habit Forming
Diet & Lifestyle Advise
- Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
- Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows; one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
- Avoid taking alcohol and smoking cigarettes. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), which prevents backflow of the stomach acid back into the food pipe.
- Include high fibre-containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal. These foods are full of antioxidants, calcium and vitamin B 12 that can help cope with the long-term effects of the medicine. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help prevent excess stomach acid production. Cranberry juice can be beneficial for peptic ulcers and H Pyroli infection.
- Avoid regular sitting continuously, as it can increase stomach acid production. Take a break of 5 minutes in 1 hour by brisk walking or stretching.
Patients Concern
Disease/Condition Glossary
Normally a thick layer of mucous protects the stomach against its own acid secretion. But, in long run, it gets eroded by excessive stomach acid production leading to complications like GERD, peptic ulcer, and Zollinger Ellison syndrome. Gastroesophageal reflux disease (GERD) is a gastrointestinal disorder that occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe that causes heartburn. On the other hand, a peptic ulcer is a painful condition followed by the development of sores or ulcers in the stomach lining or duodenum (first part of the small intestine). Zollinger Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers.
FAQs
Domperidone works by increasing the movement of food through the stomach and the digestive tract more quickly and in this way reduces the feeling of bloating, or fullness and indigestion. On the other hand, it effectively blocks the action of a vomiting centre (chemoreceptor trigger zone - CTZ) located in your brain, which is responsible for inducing the feeling of nausea and vomiting. Pantoprazole helps in reducing the stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This proton pump lies in the cells of the stomach wall responsible for the release of gastric acid secretion damaging tissues in the food pipe, stomach, and duodenum.
Pantoprazole+domperidone can be safely taken as long as your doctor has prescribed it to you.
Yes, taking Pantoprazole+domperidone for a very long time can cause calcium depletion from the body leading to weakening of bones. Hence a calcium and vitamin D supplement is recommended along with Pantoprazole+domperidone to replenish calcium depletion in the body.
Yes. Pantoprazole+domperidone can alter certain medical tests like neuroendocrine tumours (secretin stimulation test), and urine screening tests for tetrahydrocannabinol (THC). So before undergoing such diagnostics test contact your doctor.
Prolonged intake of Pantoprazole+domperidone may weaken your bone and lower haemoglobin level. Your doctor may prescribe you Vitamin B12 for enhancing haemoglobin and calcium/vitamin D/magnesium supplements for bone health.
Combination of pantoprazole and domperidone is effective & safe.
No, Pantoprazole+domperidone is a prescribed drug with minimal side effects. Only take it if your doctor has recommended it to you for acidity.
