Pantoprazole+itopride
About
Pantoprazole+itopride is a combination medicine used to lower the increased level of stomach acid. It treats GERD (gastro-oesophagal reflux disease), and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.
Pantoprazole+itopride is a combination of two drugs, namely: Pantoprazole and Itopride. Pantoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Itopride works by accelerating gastric emptying and improves gastric sensitivity and tension. It also has anti-emetic action. Together, Pantoprazole+itopride helps in preventing acid reflux, thereby providing relief from acidity.
You are advised to take Pantoprazole+itopride for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as headache, nausea, stomach pain, dizziness and diarrhoea. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Inform your doctor before taking Pantoprazole+itopride if you have a history of gastrointestinal bleeding, mechanical perforation/obstruction, or movement disorder. On long-term treatment, Pantoprazole+itopride may cause osteoporosis and hypomagnesemia (low levels of magnesium). Consult your doctor if you are pregnant or breastfeeding. Pantoprazole+itopride may cause drowsiness, so drive only if you are alert. Pantoprazole+itopride should not be given to children as safety has not been established. Avoid consuming alcohol along with Pantoprazole+itopride as it could lead to increased drowsiness and can elevate the production of stomach acid.
Uses of Pantoprazole+itopride
Medicinal Benefits
Pantoprazole+itopride is a combination of two drugs, namely: Pantoprazole and Itopride. Pantoprazole belongs to a group of medicines called proton pump inhibitors whereas itopride belongs to a group of medicines called prokinetic agents. Pantoprazole+itopride is used to treat gastro-oesophageal reflux disease (reflux of gastric contents into the oesophagus), and peptic ulcers. Pantoprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Itopride works by accelerating gastric emptying, and improves gastric sensitivity and tension. It also has anti-emetic action. Together, Pantoprazole+itopride helps in preventing acid reflux, thereby providing relief from acidity.
Directions for Use
Storage
Side Effects of Pantoprazole+itopride
- Headache
- Nausea
- Stomach pain
- Dizziness
- Diarrhoea
In-Depth Precautions and Warning
Drug Warnings
Do not take Pantoprazole+itopride if you are allergic to any of its contents. Inform your doctor before taking Pantoprazole+itopride if you have a history of gastrointestinal bleeding, mechanical perforation/obstruction, or movement disorder. Pantoprazole+itopride may cause osteoporosis and hypomagnesemia (low magnesium) on long-term treatment. Consult your doctor if you are pregnant or breastfeeding. Pantoprazole+itopride may cause dizziness, so drive only if you are alert. Pantoprazole+itopride should not be given to children as safety has not been established. Avoid consuming alcohol along with Pantoprazole+itopride as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about your medications and health condition to rule out any side-effects.
Drug Interactions
Drug-Drug Interactions: Pantoprazole+itopride may interact with pain killers (aspirin, naproxen), an antidepressant (duloxetine), hypothyroidism (levothyroxine), statins (atorvastatin), blood thinner (clopidogrel), and vitamin (vitamin b12).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have gastrointestinal bleeding, mechanical obstruction or perforation, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, or hypomagnesemia (low levels of magnesium).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Pantoprazole+itopride. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Pregnancy
cautionConsult your doctor before taking Pantoprazole+itopride if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor before taking Pantoprazole+itopride; your doctor will decide whether Pantoprazole+itopride can be taken by breastfeeding mothers or not.
Driving
cautionPantoprazole+itopride may cause dizziness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor before taking Pantoprazole+itopride if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Pantoprazole+itopride if you have kidney impairment or any concerns regarding this.
Children
unsafePantoprazole+itopride should not be given to children as safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating.
- Avoid tight-fitting clothes.
- Maintain a healthy weight by regular exercising.
- Practise relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.
Patients Concern
Disease/Condition Glossary
Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, and peptic ulcers.
Gastroesophageal reflux disease (GERD): Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers: They are sores that develop on the lining of the stomach and intestine due to erosion of stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
FAQs
Pantoprazole+itopride is a combination of two drugs, namely: Pantoprazole and Itopride. Pantoprazole works by blocking the action of an enzyme called gastric proton pump, responsible for the production of acid. Itopride works by accelerating gastric emptying and improves gastric sensitivity and tension. Together, Pantoprazole+itopride helps in preventing acid reflux, thereby provides relief from acidity.
Talk to your doctor if you do not feel better even after taking Pantoprazole+itopride for 14 days. Do not take Pantoprazole+itopride for longer durations unless prescribed by the doctor.
Diarrhoea might be a side-effect of Pantoprazole+itopride. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Pantoprazole+itopride may increase the risk of osteoporosis (weak and brittle bones). This mainly occurs in people taking higher doses of Pantoprazole+itopride for longer durations. Consult your doctor if you have any concerns.
