Pefloxacin

Do not take Pefloxacin if you are allergic to any of its contents or if you had swelling or tearing of tendons while taking quinolone antibiotics. Pefloxacin is associated with an increased risk of tendon rupture and tendonitis (inflammation of the tendon) at all age groups; this risk is higher in patients older than 60years, who are taking corticosteroids and have had kidney, heart, or lung transplants. Consult your doctor immediately if you experience tendon pain, swelling, or inflammation while taking Pefloxacin. Pefloxacin should not be taken un the conditions like kidney and liver disease, epilepsy/fit disorder, and history of brain and spinal cord disease. Avoid contact with sunlight as it may cause severe sunburn. Immediately discontinue the Pefloxacin and inform your doctor if you get itchy skin, a rash, swelling of face and mouth, or have a problem in breathing. Do not take Pefloxacin on your own, as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking Pefloxacin if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Pefloxacin as it causes increased dizziness. Pefloxacin may cause dizziness and vision problems, so be cautious while driving. Pefloxacin should not be recommended for children less than 12 years.

Drug-Drug Interaction: This Pefloxacin may have an interaction with antidiabetic medicines (chlorpropamide, glimepiride, glipizide, glyburide, metformin, tolazamide, and tolbutamide), blood thinners (aspirin, warfarin), medicines used in asthma (theophylline).

Drug-Food Interactions: Avoid dairy products such as milk and yoghurt while taking Pefloxacin as they might decrease the effectiveness of Pefloxacin.

Drug-Disease Interactions: Pefloxacin may have interactions with tendonitis (inflammation in tendons), diabetes, kidney, liver, and heart problems.

• Do not drink or eat a lot of caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. Pefloxacin may increase nervousness, sleeplessness, and anxiety caused by caffeine.
• Probiotics should be taken after taking a full course of Pefloxacin in order to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help to restore the good bacteria of the intestine. 
• Include more fibre-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet. Make sure you drink plenty of water or other fluids daily while taking Pefloxacin.
• Avoid intake of alcoholic beverages with Pefloxacin as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Pefloxacin in fighting off infections.

Tendon damage can occur after a few months of starting Pefloxacin treatment. The onset of symptoms and signs of the side effects may be delayed several months after stopping treatment. At the first sign of tendinitis (like painful swelling or inflammation), immediately stop taking Pefloxacin. The affected limbs should be appropriately treated (e.g., immobilization).