Prasugrel+aspirin
About
Prasugrel+aspirin falls into the category of medications known as 'antiplatelet agents', indicated for preventing the formation of blood clots to avoid the risk of serious heart/blood vessel problems in the future (like heart attacks, strokes, blood clots in stents). If the clots form in blood vessels like arteries are formed then it could be very dangerous as it may cut off the blood supply, causing a heart attack (myocardial infarction), stroke, or even lead to death. These clots formed in the arteries that are responsible for supplying blood to the heart which eventually reduces the supply of blood to the heart and causes unstable angina (a severe chest pain). This medication is usually prescribed to patients who have already had a heart attack or unstable angina or are already being treated with a procedure to open blocked arteries in the heart.
Prasugrel+aspirin contains 'Prasugrel' and 'Aspirin' as their active constituents. Prasugrel is an antiplatelet agent that blocks the collection of platelets in the blood cells and so decreases the chance of a blood clot formation. Platelets are very small cell particles that keep circulating in the blood. When a blood vessel is damaged, then platelets clump together to help form a blood clot. These anti-platelets effects of Prasugrel also help in the smooth flow of blood in the whole body. Aspirin has an antithrombotic action that interferes with platelet functioning and does not let them stick together, thus helping to prevent or reduce blood clots. As a combination medication, Prasugrel+aspirin reduces the risk of cardiovascular events like myocardial infarction (heart attack) or stroke in the future, especially in persons who have had heart surgery known as angioplasty.
Prasugrel+aspirin may have common side effects like headache, swelling/edema, dizziness, skin rash, small red bruises on the skin, and bruising. However not every person faces these side effects and even some off-side effects get resolved within a couple of days without any medical attention. However, a person should talk to their doctor if they are experiencing these side effects for a long time.
Prasugrel+aspirin cannot be used in children adolescents below 18 years of age. A person should not stop taking Prasugrel+aspirin on their own as it may enhance the risk of heart attack or stroke. consult your doctor before taking Prasugrel+aspirin if your weight is less than 60 kg or your age is more than 75 years or had a recent severe injury or surgery due to risk of severe bleeding problems. Prasugrel+aspirin can only be used in pregnant or breast-feeding ladies if suggested by the doctor. Prasugrel+aspirin cannot be advised to a person who had a brain stroke, bleeding in the brain, or transient ischemic attack (stroke). A regular check-up of haemoglobin (Hb) level and haematocrit count is necessary for people using Prasugrel+aspirin.
Uses of Prasugrel+aspirin
Medicinal Benefits
Prasugrel+aspirin falls in the category of medicines known as antiplatelet agents used to prevent serious heart/blood vessel problems like heart attacks, strokes, blood clots in stents by preventing the formation of blood clots. Prasugrel is responsible for inhibiting the accumulation of platelets in the blood cells which in turn reduces the chance of a blood clot formation. Platelets are very small cell particles that keep circulating in the blood and are important for stopping the bleeding. When a blood vessel gets damaged, then platelets combine together to help form a blood clot. Aspirin works as an antithrombotic action that affects platelet functioning and does not let them stick together, thus helping to prevent or reduce blood clots. As a combination medication, Prasugrel+aspirin reduces the risk of further heart attack or stokes or of dying from one of these atherothrombotic events.
Directions for Use
Storage
Side Effects of Prasugrel+aspirin
- Headache
- Swelling/edema
- Dizziness
- Skin rash
- Small red bruises on the skin
- Bruising
In-Depth Precautions and Warning
Drug Warnings
A person who is allergic to any of the contents present in Prasugrel+aspirin is not allowed to take this medicine as it may cause serious allergic reactions that include swollen lips, rash, itching, a swollen face, or shortness of breath. This medicine is not allowed to use in medical conditions like bleeding from your stomach or intestines, stroke or a transient ischaemic attack (TIA), and severe liver disease. A person should discuss with their doctor if they are 75 years or older, or faced a recent serious injury, recent surgery (including some dental procedures), recurrent bleeding from the stomach or intestines, kidney (renal) disease, or moderate liver problem. To notice the improvement in your medical condition effectually, continue taking Prasugrel+aspirin for as long as your doctor has recommended it. A person should not change the dose or stop it on their own as it may increase the risk of heart attack or stroke. Do not take Prasugrel+aspirin if you are pregnant or breastfeeding unless your doctor has prescribed it to you. Prasugrel+aspirin is not allowed to use in children as the efficacy and safety have not been established.
Drug Interactions
Drug-Drug Interaction: Prasugrel+aspirin should never be consumed with medicines like clopidogrel, dalteparin, enoxaparin, rivaroxaban, warfarin (used to prevent blood clotting), esomeprazole, omeprazole (used to relieve acidity), celecoxib, hydrocodone, ibuprofen, tramadol (used to relieve pain), and ticagrelor (used to prevent heart attack or stroke).
Drug-Food Interaction: No interactions found.
Drug-Disease Interaction: It has been reported that Prasugrel+aspirin may have interactions with bleeding, coronary, and cerebral vascular disease, liver, and kidney disease.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeA person is not allowed to consume alcohol while taking Prasugrel+aspirin as it may cause unpleasant side-effects. Alcohol intake might increase the risk of stomach or intestine bleeding.
Pregnancy
cautionIt is recommended to consult your doctor before taking Prasugrel+aspirin in pregnancy as your doctor will prescribe this drug only if the benefits outweigh the risks.
Breast Feeding
cautionIt is advised to consult with your doctor if you are a breastfeeding woman, as in this case, the doctor will prescribe this medicine if the benefits outweigh the risks.
Driving
safe if prescribedPrasugrel+aspirin does not affect the thinking ability to drive. However, do not drive or operate heavy machinery if you are not alert.
Liver
cautionDose modification may be required. Prasugrel+aspirin should be used with care in patients with liver impairment/liver disorder. A person should consult with their specialist if they have liver impairment/liver disease or any concerns regarding this.
Kidney
cautionDose adjustment may be required. Prasugrel+aspirin should be used with care in patients with kidney impairment/kidney disease. Please discuss with your doctor if you have kidney impairment/kidney disorder or any concerns regarding this.
Children
unsafePrasugrel+aspirin should not be used by children, as the efficacy and safety have not been established.
Habit Forming
Diet & Lifestyle Advise
- It is advised to engage in regular exercise to complement treatment with Prasugrel+aspirin.
- Maintaining a healthy weight with proper diet and exercise is important for good heart health.
- Limit smoking and alcohol consumption as it may increase the chances of excessive bleeding.
- A person should strictly avoid eating fried food, fast food, boxed food, canned food, and processed frozen meals.
- One should eat a nutritious diet rich in whole grains, vegetables, fruits, skinless poultry, fish, eggs, and low-fat dairy products.
- One should do relaxing activities to manage stress like meditation, yoga, massage would also help in treating high blood pressure.
Special Advise
- Certain diagnostic tests like hemoglobin and hematocrit diagnostic tests can help in checking hemoglobin levels.
- To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.
Patients Concern
Disease/Condition Glossary
Blood clot and myocardial infarction: Platelets are very small cell particles that keep circulating in the blood. However, when a blood vessel gets damaged, like if it is cut, then platelets stick together to form a blood clot (thrombus) that prevents further outflow of blood or excessive loss of blood. The formation of clots in arteries can cut off the blood supply, leading to heart attack, stroke or death. Clot formation in the arteries that supply blood to the heart may cause reduced blood flow which could lead to unstable angina (chest pain). Thus platelets are important for stopping the bleeding. If clots get formed within a hardened blood vessel like an artery then they can cut off the blood supply and even cause a heart attack (myocardial infarction), stroke, or death. The formation of clots in arteries also reduces the blood supply to the heart and even cause unstable angina (a severe chest pain).
FAQs
Prasugrel+aspirin consists of Prasugrel and Aspirin which are responsible for inhibiting the accumulation of platelets in the blood cells which in turn reduces the chance of a blood clot formation. In this way, Prasugrel+aspirin helps in reducing the risk of cardiovascular events such as myocardial infarction (heart attack) or stroke.
A person taking any anti-coagulant like warfarin is restricted to take Prasugrel+aspirin as it may increase the risk of bleeding. Consult your doctor for further advice.
A person should seek medical attention immediately if they develop a medical condition called Thrombotic Thrombocytopenic Purpura (or TTP) that cause fever and bruising under the skin or noticing unexplained extreme tiredness, confusion, yellowing of the skin or eyes (jaundice).
This medicine should not be used in children and adolescents below 18 years of age.
As Prasugrel+aspirin prevents the formation of blood clots so it is possible that a person taking Prasugrel+aspirin is at higher risk of bleeding during injury, cut, or surgery. Thus, consult your doctor if you notice excessive bleeding.
A person should limit the consumption of alcohol by taking Prasugrel+aspirin as alcohol may increase the risk of stomach bleeding.
It has been reported that Prasugrel+aspirin may cause anemia (low hemoglobin and low red blood cell count). So it would be best if a person takes iron-rich food in their diet to prevent anemia.
