Rabeprazole+cinitapride
About
Rabeprazole+cinitapride belongs to a class of drugs called gastrointestinal agents used to treat gastroesophageal reflux disease (GERD), peptic ulcers and Zollinger-Ellison syndrome. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach. Zollinger-Ellison syndrome is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production.
Rabeprazole+cinitapride is a combination of two drugs: Rabeprazole (proton pump inhibitor) and Cinitapride (gastroprokinetic agent). Rabeprazole works by blocking the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe. On the other hand, Cinitapride increases the food pipe movement (oesophagus), small intestine and stomach, thereby enhancing bowel movement and the digestive tract gets emptied from the food in a shorter time. Together, Rabeprazole+cinitapride helps in preventing acid reflux, thereby provides relief from hyperacidity and heartburn.
Take Rabeprazole+cinitapride as prescribed by your doctor. You are advised to take Rabeprazole+cinitapride for as long as your doctor has prescribed it for you based on your medical condition. You may experience diarrhoea, nausea, vomiting, headache, dizziness, flatulence (gas), stomach pain, or constipation in some cases. Most of these side effects of Rabeprazole+cinitapride do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Rabeprazole+cinitapride or any other medicines, please tell your doctor. Rabeprazole+cinitapride is not recommended for children as safety and effectiveness were not established. Avoid taking Rabeprazole+cinitapride if you are pregnant, especially in the first 3 months of pregnancy as it may cause harm to the fetus. Therefore, if you are pregnant or breastfeeding, please inform your doctor before taking Rabeprazole+cinitapride. Inform your doctor if you have any risk factors for reduced vitamin B12 as Rabeprazole+cinitapride may reduce the absorption of vitamin B12. Drive only if you are alert as Rabeprazole+cinitapride may cause drowsiness. Avoid alcohol consumption as it may lead to increased stomach acid production, thereby increasing acidity and heartburn.
Uses of Rabeprazole+cinitapride
Medicinal Benefits
Rabeprazole+cinitapride is a combination of two drugs, namely: Rabeprazole and Cinitapride used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. Rabeprazole blocks the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe. On the other hand, Cinitapride increases the food pipe movement (esophagus), small intestine, and stomach, thereby enhancing bowel movement and the digestive tract gets emptied from the food in a shorter time. Together, Rabeprazole+cinitapride helps in preventing acid reflux, thereby providing relief from hyperacidity and heartburn.
Directions for Use
Storage
Side Effects of Rabeprazole+cinitapride
- Diarrhoea
- Nausea
- Vomiting
- Headache
- Dizziness
- Flatulence (gas)
- Stomach pain
- Constipation
In-Depth Precautions and Warning
Drug Warnings
If you are allergic to Rabeprazole+cinitapride or any other medicines, please tell your doctor. Rabeprazole+cinitapride is not recommended for children as safety and effectiveness were not established. Avoid taking Rabeprazole+cinitapride if you are pregnant, especially in the first 3 months of pregnancy as it may cause harm to the fetus. Therefore, if you are pregnant or breastfeeding, please inform your doctor before taking Rabeprazole+cinitapride. If you have a stomach tumor, liver problems, bleeding, low magnesium levels in the blood, osteoporosis (weak and brittle bones), or lupus (an autoimmune disorder), inform your doctor before taking Rabeprazole+cinitapride. Inform your doctor if you have any risk factors for reduced vitamin B12 as Rabeprazole+cinitapride may reduce the absorption of vitamin B12. If you get any skin rash, particularly in areas exposed to sun, or have pain in joints, inform your doctor. If you are taking Rabeprazole+cinitapride for more than 1 year, it may increase the risk of fracture of the spine, hip, or wrist. Drive only if you are alert as Rabeprazole+cinitapride may cause drowsiness. Avoid alcohol consumption as it may lead to increased stomach acid production, thereby increasing acidity and heartburn. Rabeprazole+cinitapride may decrease magnesium levels in the blood, especially if taken for more than 3 months. Therefore, regular blood tests are recommended to monitor magnesium levels. If you experience bloody or watery diarrhoea with symptoms such as stomach pain, fever, or tenderness, contact your doctor immediately.
Drug Interactions
Drug-Drug Interaction: Rabeprazole+cinitapride may interact with the anti-HIV drug (atazanavir), antifungals (ketoconazole, itraconazole), anticancer drug (methotrexate), heart-related medicine (digoxin), blood thinner (warfarin, clopidogrel), pain reliever (aspirin), anticholinergic drugs (atropine), antipsychotic (phenothiazine), opioid analgesics (morphine, fentanyl), an antidepressant (duloxetine), medicines to treat thyroid (levothyroxine), and vitamin (cyanocobalamin).
Drug-Food Interaction: Rabeprazole+cinitapride may interact with St. John’s wort (herbal supplement used to treat depression). Avoid alcohol consumption as alcohol intake leads to increased production of stomach acid, thereby irritates the stomach lining and worsen the symptoms.
Drug-Disease Interaction: If you have a stomach tumour, liver problems, bleeding, low magnesium levels in the blood, osteoporosis (weak and brittle bones), or lupus (an autoimmune disorder), inform your doctor before taking Rabeprazole+cinitapride.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption as it may lead to increased stomach acid production, thereby irritating the stomach lining and worsening the symptoms.
Pregnancy
unsafeRabeprazole+cinitapride is not recommended for pregnant women, especially in the first 3 months of pregnancy as it may cause harm to the foetus. Please consult a doctor if you are pregnant.
Breast Feeding
cautionIt is unknown whether Rabeprazole+cinitapride is excreted in human milk. Rabeprazole+cinitapride is given to breastfeeding mothers if the doctor thinks benefits are more significant than risks. Please consult a doctor if you are breastfeeding.
Driving
cautionRabeprazole+cinitapride may cause drowsiness in some people. Therefore, avoid driving or operating machinery if you feel drowsy after taking Rabeprazole+cinitapride.
Liver
cautionTake Rabeprazole+cinitapride with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.
Kidney
cautionTake Rabeprazole+cinitapride with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Children
unsafeRabeprazole+cinitapride is not recommended for children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating as it causes acid reflux.
- Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
- Practice relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Special Advise
- Regular blood tests are recommended while taking Rabeprazole+cinitapride to monitor magnesium levels in the blood.
- Rabeprazole+cinitapride may cause some abnormal liver enzyme and blood values. These changes are temporary and may return to normal after treatment with Rabeprazole+cinitapride is discontinued.
Patients Concern
Disease/Condition Glossary
Gastroesophageal reflux disease (GERD): The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets irritated or eroded, which leads to complications like GERD, hyperacidity, peptic ulcers, and heartburn. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (esophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, a sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers: These are sores that develop on the stomach and intestine lining due to erosion of the stomach's protective lining. Symptoms include nausea, appetite changes, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
Zollinger-Ellison syndrome: It is characterized by the formation of tumors in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting.
FAQs
Rabeprazole+cinitapride contains Rabeprazole and Cinitapride. Rabeprazole works by blocking the action of proton pumps that are involved in producing stomach acid. Thereby, it reduces the amount of acid produced by the stomach and prevents excess acid flowing back into the food pipe. On the other hand, Cinitapride increases the movement of the food pipe (oesophagus), small intestine and stomach, thereby enhancing bowel movement and digestive tract gets emptied from the food in a shorter time. Together, Rabeprazole+cinitapride helps in preventing acid reflux, thereby provides relief from hyperacidity and heartburn.
Rabeprazole+cinitapride may cause diarrhoea as a common side effect. However, if the condition persists or worsens with fever, watery or bloody stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while taking Rabeprazole+cinitapride to prevent dehydration.
Rabeprazole+cinitapride may cause low levels of magnesium in the blood if taken for more than 3 months. If you experience involuntary muscle contractions, fits, tiredness, increased heart rate or dizziness while taking Rabeprazole+cinitapride, please consult a doctor immediately as these might be signs of low magnesium levels. However, regular blood tests are recommended to monitor magnesium levels in the blood while taking Rabeprazole+cinitapride.
You are not recommended to take Rabeprazole+cinitapride with antifungals such as ketoconazole or itraconazole as it may reduce the effectiveness of antifungal against fungal infections. However, please consult your doctor before taking Rabeprazole+cinitapride with other medicines.
Rabeprazole+cinitapride may reduce the absorption of vitamin B12 and lead to its deficiency if used for more than 3 years. Therefore, inform your doctor if you have any risk factors for reduced vitamin B12 before taking Rabeprazole+cinitapride.
Rabeprazole+cinitapride should be used with caution in osteoporosis (weak and brittle bones) patients as it may worsen the condition especially if Rabeprazole+cinitapride is taken for more than 1 year as it increases the risk of fracture of the spine, hip or wrist. Therefore, inform your doctor if you have osteoporosis or take any steroids which may increase the risk of osteoporosis.
Rabeprazole+cinitapride may cause tardive dyskinesia (involuntary and abnormal movements) in elderly patients if taken for a prolonged time. Therefore, it is recommended to use Rabeprazole+cinitapride only for the duration as prescribed by a doctor.
