Rabeprazole+domperidone+zinc
About
Rabeprazole+domperidone+zinc belongs to a group of medicines called gastrointestinal agents used to treat acidity, heartburn, gastro-oesophageal reflux disease (GERD). The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, leading to complications like GERD and acidity. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn.
Rabeprazole+domperidone+zinc is a combination of three medicines: Rabeprazole (proton pump inhibitor), domperidone (a dopamine antagonist), and zinc (nutrition supplement). Rabeprazole is a type of medicine called a proton pump inhibitor (PPI). Rabeprazole works by decreasing the acid amount in the stomach, which helps reduce acid-related indigestion and heartburn. Domperidone works by increasing the movement of food through the stomach and the digestive tract more quickly and in this way reduces the feeling of bloating, or fullness and indigestion. It also blocks messages between parts of your brain called the chemoreceptor trigger zone (CTZ) and the vomiting centre. This stops you from feeling sick (nauseous) and prevents you from vomiting. Zinc is a nutritional supplement that speeds up the ulcers healing in the intestine and stomach. Together, Rabeprazole+domperidone+zinc helps treat acidity related problems.
Take Rabeprazole+domperidone+zinc as prescribed by your doctor. You are advised to take Rabeprazole+domperidone+zinc for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience diarrhoea, stomach pain, dryness in the mouth, flatulence, dizziness, headache, weakness, and flu-like symptoms. Most of these side effects of Rabeprazole+domperidone+zinc do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Inform your doctor before taking Rabeprazole+domperidone+zinc if you have a history of gastrointestinal bleeding or intestinal obstruction. Talk to your doctor before taking Rabeprazole+domperidone+zinc if you have osteoporosis: Rabeprazole+domperidone+zinc may increase bone fractures' risk on long-term treatment. Consult your doctor before taking Rabeprazole+domperidone+zinc if you are pregnant or breastfeeding. Rabeprazole+domperidone+zinc may cause dizziness, so drive only if you are alert. Rabeprazole+domperidone+zinc should not be given to children as safety has not been established. Avoid consuming alcohol and Rabeprazole+domperidone+zinc as it could lead to increased drowsiness and elevate stomach acid production. Keep your doctor informed about your health condition and medicines to rule out any side-effects.
Uses of Rabeprazole+domperidone+zinc
Medicinal Benefits
Rabeprazole+domperidone+zinc is a combination of three medicines: Rabeprazole (proton pump inhibitor), Domperidone (a dopamine antagonist), and Zinc (nutrition supplement). Rabeprazole+domperidone+zinc is primarily used to treat acidity, heartburn, gastro-oesophageal reflux disease (GERD). Besides this Rabeprazole+domperidone+zinc is also used to treat Zollinger-Ellison syndrome, nausea, vomiting, the fullness of stomach, bloating, gas, helicobacter pylori infection, gastric and duodenal ulcers. Rabeprazole is a type of medicine called a proton pump inhibitor (PPI). Proton pumps are tiny substances in the stomach lining that help it make acid to digest food. Rabeprazole prevents proton pumps from working properly. This reduces the amount of acid your stomach makes. Domperidone is a dopamine antagonist that works by increasing the movements and contractions of stomach muscle. Zinc is a nutritional supplement which speeds up the ulcers healing in intestine and stomach. Together, Rabeprazole+domperidone+zinc helps treat acidity related problems.
Directions for Use
Storage
Side Effects of Rabeprazole+domperidone+zinc
- Diarrhea
- Stomach pain
- Dryness in mouth
- Flatulence
- Dizziness
- Headache
- Weakness
- Flu-like symptoms
In-Depth Precautions and Warning
Drug Warnings
Do not take Rabeprazole+domperidone+zinc if you are allergic to any of its contents; if you are taking atazanavir (used to treat HIV); if you have galactose intolerance, lactase deficiency, glucose-galactose malabsorption, electrolyte disturbance, heart failure, or gastrointestinal haemorrhage. Inform your doctor before taking Rabeprazole+domperidone+zinc if you have a stomach tumour, kidney, heart, or liver disease, or if you are due to have Chromogranin A blood test. On long-term treatment, Rabeprazole+domperidone+zinc may cause low magnesium levels, vitamin B12 levels, and increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition. Do not take Rabeprazole+domperidone+zinc if you are pregnant or breastfeeding unless prescribed by the doctor. Rabeprazole+domperidone+zinc may cause dizziness, so drive only if you are alert. Rabeprazole+domperidone+zinc should not be given to children as safety has not been established. Avoid consuming alcohol and Rabeprazole+domperidone+zinc as it could lead to increased drowsiness and elevate stomach acid production. Prolonged intake of Rabeprazole+domperidone+zinc is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor.
Drug Interactions
Drug-Drug Interactions: Rabeprazole+domperidone+zinc may have interaction with painkillers (aspirin), anti-HIV (atazanavir, nelfinavir, saquinavir), blood thinner (clopidogrel, warfarin), a drug used to treat hypothyroidism (levothyroxine), anti-rheumatoid (methotrexate), anti-depressant (duloxetine), vitamin (cyanocobalamin), and cardiac glycoside (digoxin).
Drug-Food Interactions: Rabeprazole+domperidone+zinc may have interaction with St.John’s wort (herbal supplement used to treat depression). Avoiding alcohol consumption as alcohol intake leads to increased stomach acid production, thereby increasing acidity and heartburn.
Drug-Disease Interactions: Rabeprazole+domperidone+zinc may have interactions with epilepsy, mania, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, hypomagnesemia (low levels of magnesium).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Rabeprazole+domperidone+zinc. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Pregnancy
cautionConsult your doctor before taking Rabeprazole+domperidone+zinc if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor before taking Rabeprazole+domperidone+zinc; your doctor will decide whether Rabeprazole+domperidone+zinc can be taken by breastfeeding mothers or not.
Driving
unsafeRabeprazole+domperidone+zinc may cause dizziness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor before taking Rabeprazole+domperidone+zinc if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Rabeprazole+domperidone+zinc if you have kidney impairment or any concerns regarding this.
Children
cautionRabeprazole+domperidone+zinc should be given to children only if prescribed by the doctor as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating as it causes acid reflux.
- Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
- Practice relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea, and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes break every hour by doing brisk walking or stretching.
Special Advise
Prolonged intake of proton pump inhibitors like pantoprazole, rabeprazole, esomeprazole, omeprazole etc. may lower your magnesium and vitamin B12 level in your body. Hence, your doctor might prescribe calcium and magnesium supplements to you during the treatment.
Patients Concern
Disease/Condition Glossary
The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, peptic ulcers, and Zollinger-Ellison syndrome. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing. Gastric ulcers are sores that develop on the stomach and intestine lining due to erosion of the stomach protective lining. Symptoms include nausea, appetite changes, bloody or dark stools, unexplained weight loss, vomiting, and indigestion. Zollinger-Ellison syndrome is characterized by the formation of tumours in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting.
FAQs
Rabeprazole+domperidone+zinc is a combination of three drugs, namely: Rabeprazole and domperidone, and zinc. Rabeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for acid production. Domperidone works by increasing the movements and contractions of stomach muscles. Zinc is a nutritional supplement that speeds up the ulcers healing in the intestine and stomach. Together, Rabeprazole+domperidone+zinc helps in treating acidity.
Dry mouth could be a side-effect of Rabeprazole+domperidone+zinc. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Yes, acidity may arise in new-born babies because there is an undeveloped gastrointestinal tract in new-born babies. There is poor coordination of muscles in the stomach which may cause reflux of stomach content upwards, and the infant may vomit also.
Acidic fruits and foods like citrus fruits (orange, lemon), grapes, etc. may stimulate acid contents in the stomach and cause acidity problems. Banana is a low acid comprising food that may be helpful in patients with heartburn or acidity. On the other hand, cucumber is an alkaline food, thus normally does not cause acidity problems.
Rabeprazole+domperidone+zinc contains domperidone, which helps treat nausea and vomiting by increasing the movements and contractions of stomach muscle. Domperidone block triggering of CTZ receptor, which is the centre point of vomiting.
Do not take Rabeprazole+domperidone+zinc for longer durations unless prescribed by the doctor. Consult your doctor if your condition does not improve even after taking Rabeprazole+domperidone+zinc for 14 days.