Rabeprazole+ondansetron
About
Rabeprazole+ondansetron is a gastrointestinal medication, primarily used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, and erosive oesophagitis (acid-related damage to the lining of the oesophagus). Rabeprazole+ondansetron is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome. GERD is a condition that occurs when stomach acid frequently flows back into the food pipe (oesophagus). Zollinger Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers.
Rabeprazole+ondansetron contains two medicines: Rabeprazole and Ondansetron. Rabeprazole belongs to the group of drugs called ‘proton pump inhibitors.’ It blocks the action of the gastric proton pump that is responsible for the production of acid in the stomach. This reduces the amount of acid produced, heals the ulcers, and prevents the formation of new ulcers. Ondansetron belongs to the class of anti-emetics (prevents vomiting). It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting.
Take Rabeprazole+ondansetron as advised by the doctor. Your doctor will advise the appropriate dose that suits your medical condition. Common side effects of Rabeprazole+ondansetron include nausea, vomiting, constipation, headache, fatigue, diarrhoea, sore throat, and abdominal pain. These side effects may not occur in every patient using this medication and differ individually. If the side effects persist longer or worsen, please seek a doctor’s advice.
Let your doctor know if you are sensitive or allergic to Rabeprazole+ondansetron or any other medications. Before using Rabeprazole+ondansetron, let your doctor know if you have any liver, kidney or heart diseases, and gastrointestinal problems. Pregnant and breastfeeding women should consult their doctor before using Rabeprazole+ondansetron. Avoid alcohol intake while using Rabeprazole+ondansetron since it can increase acid production in the stomach. Ondansetron in Rabeprazole+ondansetron is not recommended for children below four years of age.
Uses of Rabeprazole+ondansetron
Medicinal Benefits
Rabeprazole+ondansetron is used to treat nausea, vomiting, stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn and erosive oesophagitis. It contains Rabeprazole and Ondansetron. Rabeprazole is a proton pump inhibitor that blocks the action of the gastric proton pump that is responsible for acid production in the stomach. Ondansetron is an anti-emetic drug. It works by blocking the action of serotonin (chemical messenger) that triggers nausea and vomiting. Thus, collectively Rabeprazole+ondansetron prevents nausea and vomiting, reduces the amount of acid produced, heals the ulcers, and prevents new ulcers. Rabeprazole+ondansetron is also used to treat infections caused by Helicobacter pylori and Zollinger-Ellison syndrome.
Directions for Use
Storage
Side Effects of Rabeprazole+ondansetron
- Nausea
- Vomiting
- Constipation
- Headache
- Fatigue
- Diarrhoea
- Sore throat
- Abdominal pain
In-Depth Precautions and Warning
Drug Warnings
Let your doctor know if you are sensitive to Rabeprazole+ondansetron or its components. Rabeprazole+ondansetron should be used with caution and only under doctor’s supervision if you have stomach/intestinal problems, liver, kidney or heart diseases, recent abdominal surgery, risk of bone fractures and autoimmune diseases like lupus. Long term treatment with Rabeprazole+ondansetron may increase the risk of fractures of the hip, spine, and wrist. Hence, inform your doctor if you have osteoporosis, bone-related problems, or taking any corticosteroids before starting Rabeprazole+ondansetron. Let your doctor know if you are pregnant or a nursing mother before starting Rabeprazole+ondansetron. Avoid alcohol intake while using Rabeprazole+ondansetron since it can increase acid production in the stomach.
Drug Interactions
Drug-Drug Interaction: Rabeprazole+ondansetron may interact with pain killers (acetaminophen, ibuprofen), anti-anxiety (pregabalin, diazepam), antiparkinson medicine (apomorphine), anti-depressants (duloxetine), blood thinners (clopidogrel), a drug used to treat hypothyroidism (levothyroxine), anti-HIV (atazanavir), antifungals (ketoconazole), anti-cancer drugs (methotrexate), and vitamins (cyanocobalamin).
Drug-Food Interaction: Avoid fatty foods, alcohol, caffeine, and other triggering foods that can worsen your gastrointestinal problems.
Drug-Disease Interaction: Brief your doctor if you have a medical history of stomach/intestinal problems, liver, kidney or heart diseases, recent abdominal surgery, risk of bone fractures, autoimmune diseases like lupus, and Vitamin B12 deficiency before starting Rabeprazole+ondansetron.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAlcohol consumption may increase acid production in the stomach. It is advised to avoid alcohol intake to prevent any undesirable side effects of Rabeprazole+ondansetron and further worsening of your disease. Please consult your doctor for more information before using Rabeprazole+ondansetron.
Pregnancy
cautionRabeprazole+ondansetron is not recommended for use in pregnancy since Ondansetron may cause harmful effects on the developing baby. It is advised to consult your doctor if you plan to conceive or already pregnant before starting Rabeprazole+ondansetron.
Breast Feeding
cautionIt is not known if Rabeprazole+ondansetron passes into breast milk. Please consult your doctor before taking Rabeprazole+ondansetron if you are a nursing mother.
Driving
safe if prescribedRabeprazole+ondansetron is probably safe to use and doesn’t affect driving. However, please do not drive or operate machines if you experience any side effects that affect your ability to drive.
Liver
cautionLet your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Rabeprazole+ondansetron.
Kidney
cautionLet your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Rabeprazole+ondansetron.
Children
cautionOndansetron in Rabeprazole+ondansetron may not be suitable for children below four years of age. Please consult your doctor before giving Rabeprazole+ondansetron to your child. Your doctor will decide the dose and duration based on your child’s age and medical condition.
Habit Forming
Diet & Lifestyle Advise
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
- Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
- Limit taking high fibre foods, foods and drinks that contain chocolate, alcohol, caffeine, fructose, or sorbitol, carbonated drinks, fried, and fatty foods.
- Do not have large meals at a time, instead try having small and simpler meals at regular intervals, including fresh fruits and vegetables in your diet.
- Practice yoga and recreation techniques to manage your emotional stress.
- If you are lactose intolerant, avoid using dairy products since it can worsen your stomach discomforts.
- If you cannot take dairy products, it is advised to include other calcium-rich foods like leafy greens, beans, nuts, and seeds.
- Drink plenty of fluids to prevent dehydration.
Special Advise
- It is advised to monitor your blood pressure and blood glucose levels regularly while using Rabeprazole+ondansetron.
- Your doctor may suggest diagnostic procedures like endoscopy or colonoscopy to understand your disease and its severity.
- Rabeprazole+ondansetron may cause abnormal blood and liver enzyme tests. Inform your doctor and laboratory staff that you are taking Rabeprazole+ondansetron before undergoing any examinations.
Patients Concern
Disease/Condition Glossary
Gastrointestinal diseases: The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like acidity, GERD, heartburn, stomach ulcer, and Zollinger Ellison syndrome. Gastroesophageal reflux disease (GERD) is a condition that occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Zollinger Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers.
Nausea/Vomiting: Nausea is an uneasy feeling in the stomach in which a person feels a strong urge to vomit. Vomiting is a natural response of the body in which a person wants to expel stomach contents from the mouth forcefully. It can be triggered by taste, anxiety, smell, pain, or irritation to the stomach.
FAQs
Rabeprazole+ondansetron works by reducing the amount of acid produced in the stomach and blocks the action of certain chemical messengers that trigger nausea and vomiting. Thus, Rabeprazole+ondansetron relieves stomach ulcers, heartburn, GERD, nausea, vomiting and other gastrointestinal discomforts.
Rabeprazole+ondansetron should be used with caution and only under doctor’s supervision if you have any liver, kidney or heart diseases, stomach and intestinal problems, recent abdominal surgery, Vitamin B12 deficiency, risk of bone fractures and autoimmune diseases like lupus.
Talk to your doctor if you do not feel better even after taking Rabeprazole+ondansetron for 14 days. Do not take Rabeprazole+ondansetron for longer durations unless prescribed by the doctor. If Rabeprazole+ondansetron is prescribed for longer durations, a regular check-up is advised.
Antacids do not interfere with the absorption of Rabeprazole+ondansetron. However, it is advised to take antacid and Rabeprazole+ondansetron at different times. Please seek medical advice on how to use other medicines like antacids while using Rabeprazole+ondansetron.
Diarrhoea might be a side-effect of Rabeprazole+ondansetron. Drink lots of fluids and eat foods rich in fibre if you experience diarrhoea. If you find blood in stools (tarry stools) or experience excess diarrhoea, consult your doctor. Prolonged intake of Rabeprazole+ondansetron is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor.
On long term treatment, Rabeprazole in Rabeprazole+ondansetron may increase the risk of fractures of the hip, spine, and wrist. Inform your doctor if you have osteoporosis, bone-related problems, or taking any corticosteroids. Your doctor may suggest supplements like Calcium citrate and Vitamin D.
Rabeprazole in Rabeprazole+ondansetron may cause low Vitamin B12 levels on long term usage. Your doctor may adjust the dose of Rabeprazole+ondansetron accordingly and may also suggest Vitamin B12 supplements.
