Saxagliptin+dapagliflozin
About
Saxagliptin+dapagliflozin belongs to the group of anti-diabetic medicines used to treat type-2 diabetes mellitus adjunct to diet and exercise. Type-2 diabetes mellitus is also known as non-insulin-dependent diabetes or adult-onset diabetes. Saxagliptin+dapagliflozin is not indicated to treat diabetic ketoacidosis or type-1 diabetes mellitus.
Saxagliptin+dapagliflozin is a combination of two drugs, namely: Saxagliptin (dipeptidyl peptidase-4 inhibitor) and Dapagliflozin (sodium-glucose cotransporter-2 inhibitors). Saxagliptin enhances glucose-mediated insulin secretion, thereby reduces fasting and post-prandial blood sugar concentrations. Dapagliflozin removes excess sugar from the body via urine. Together, Saxagliptin+dapagliflozin helps treat type-2 diabetes mellitus.
You are advised to take Saxagliptin+dapagliflozin for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as urinary tract infection, hypoglycaemia, upper respiratory tract infection, and dyslipidaemia. You are advised to consult your doctor if the side effects persist or worsen.
Avoid taking Saxagliptin+dapagliflozin if you are pregnant or breastfeeding. Saxagliptin+dapagliflozin is not recommended for children below 18 years as safety and effectiveness have not been established. Avoid alcohol consumption while taking Saxagliptin+dapagliflozin as it might cause unpleasant side-effects. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.
Uses of Saxagliptin+dapagliflozin
Medicinal Benefits
Saxagliptin+dapagliflozin is a combination of two drugs, namely: Saxagliptin and Dapagliflozin. Saxagliptin+dapagliflozin belongs to the group of anti-diabetic medicines used to treat type-2 diabetes mellitus adjunct to diet and exercise. Saxagliptin is a dipeptidyl peptidase-4 inhibitor that enhances glucose-mediated insulin secretion, thereby reducing fasting and post-prandial blood sugar concentrations. Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor that removes excess sugar from the body via urine. Together, Saxagliptin+dapagliflozin helps treat type-2 diabetes mellitus.
Directions for Use
Storage
Side Effects of Saxagliptin+dapagliflozin
- Urinary tract infection
- Hypoglycaemia (low blood glucose levels)
- Upper respiratory tract infection
- Dyslipidaemia (high levels of lipids)
In-Depth Precautions and Warning
Drug Warnings
Do not take Saxagliptin+dapagliflozin if you are allergic to any of its components. Inform your doctor if you have type-1 diabetes mellitus, pancreas disorder, AIDS, reduced kidney function, diabetic ketoacidosis, heart disease, liver problems, high/low blood pressure, infections, if you are older than 75years, if you are taking insulin, sulphonylurea or pioglitazone. Avoid taking Saxagliptin+dapagliflozin if you are pregnant or breastfeeding. Saxagliptin+dapagliflozin is not recommended for children below 18 years as safety and effectiveness have not been established. Avoid alcohol consumption while taking Saxagliptin+dapagliflozin as it might cause unpleasant side-effects. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects.
Drug Interactions
Drug-Drug Interactions: Saxagliptin+dapagliflozin may interact with diuretics, anti-convulsant (carbamazepine, phenobarbital, phenytoin), corticosteroid (dexamethasone), antibiotic (rifampicin), anti-fungal (ketoconazole), calcium channel blocker (diltiazem).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have diabetic ketoacidosis, type-1 diabetes mellitus, infections, pancreatitis, low blood sugar levels, heart, kidney or liver problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionYou are recommended to avoid alcohol consumption while taking Saxagliptin+dapagliflozin to prevent unpleasant side effects.
Pregnancy
unsafeSaxagliptin+dapagliflozin is not recommended for use during pregnancy. Please consult your doctor if you have any concerns.
Breast Feeding
unsafeIt is not known if Saxagliptin+dapagliflozin passes into breast milk. Therefore, avoid taking Saxagliptin+dapagliflozin if you are breastfeeding. Please consult your doctor if you have any concerns.
Driving
cautionGenerally, Saxagliptin+dapagliflozin does not affect your ability to drive. However, in some cases, Saxagliptin+dapagliflozin might cause dizziness or low blood sugar levels leading to sweating, shakiness, and changes in vision. Therefore, drive or operate machinery only if you are alert.
Liver
cautionDose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
unsafeSaxagliptin+dapagliflozin is not recommended for children below 18 years as safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Include foods rich in healthy carbohydrates and fibre, fruits, whole grains, and vegetables in your diet.
- Try eating food at regular intervals. Do not skip meals. Also, try not to overeat.
- Follow a healthy diet and walk for at least 45 minutes to complement treatment with Saxagliptin+dapagliflozin.
- Maintain a healthy weight by exercising regularly.
- Rest properly, avoid stress by doing meditation or yoga.
Special Advise
- Regularly monitor blood glucose levels while taking Saxagliptin+dapagliflozin.
- Try not to skip any doses and take Saxagliptin+dapagliflozin for as long as your doctor has prescribed it for you.
- Your urine will test positive for sugar whilst on treatment with Saxagliptin+dapagliflozin. Inform the person doing the test that you are taking Saxagliptin+dapagliflozin.
- Saxagliptin+dapagliflozin might cause changes in laboratory tests such as creatinine renal clearance and haematocrit. Inform the person doing the test that you are taking Saxagliptin+dapagliflozin.
- Kidney function should be checked before starting and whilst on treatment with Saxagliptin+dapagliflozin.
Patients Concern
Disease/Condition Glossary
Type-2 diabetes mellitus: It is also known as non-insulin-dependent diabetes. It is a chronic or lifelong disease that keeps the body from utilizing insulin properly. Diabetes is a medical condition in which blood glucose levels are above normal. People with type 2 diabetes either do not produce enough insulin, or the insulin produced cannot perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes; hence it is also known as adult-onset diabetes. Type 2 diabetes symptoms include lack of energy, tiredness, frequent urination, excess thirst, dry mouth, blurry vision, constant hunger, weight loss, and itchy skin.
FAQs
Saxagliptin+dapagliflozin contains Saxagliptin and Dapagliflozin. Saxagliptin enhances glucose-mediated insulin secretion, thereby reduces fasting and post-prandial blood sugar concentrations. Dapagliflozin removes excess sugar from the body via urine. Together, Saxagliptin+dapagliflozin helps treat type-2 diabetes mellitus.
Do not stop taking Saxagliptin+dapagliflozin without consulting your doctor, as it may cause an increase in blood glucose levels. Continue taking Saxagliptin+dapagliflozin for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Saxagliptin+dapagliflozin.
Dehydration could be a side-effect of Saxagliptin+dapagliflozin. Drink plenty of fluids if you experience any symptoms of dehydration such as dry mouth, feeling thirsty, tiredness, sleepiness, passing less urine, and fast heartbeat.
Saxagliptin+dapagliflozin may sometimes lower the blood glucose levels more than normal, leading to hypoglycemia. Regularly monitor your blood sugar levels while taking Saxagliptin+dapagliflozin. Hypoglycemia symptoms include headache, dizziness, drowsiness, shakiness, faintness, confusion, and visual disturbances.
Maintain a healthy diet by regular intake of carbohydrates. Eat your meals regularly, and do not exercise heavily for longer durations with an empty stomach.
