Silodosin+dutasteride
About
Silodosin+dutasteride is a combination of medicine primarily used to treat the symptoms of benign prostatic hyperplasia (BPH) in adults with an enlarged prostate gland. It helps to relieve symptoms such as difficulty urinating or urge to urinate more often and improve your ability to urinate. The prostate is a small, muscular gland in the male reproductive system. Enlargement of the prostate is called BPH common condition as men get older (50-60 years). It occurs when the cells of the prostate gland begin to multiply. In an enlarged prostate gland, the bladder wall becomes thicker, and the bladder may weaken and lose the ability to empty fully, leaving some urine in the bladder.
Silodosin+dutasteride is a combination of two drugs, namely; Silodosin and Dutasteride. Silodosin belongs to a class of alpha-1 receptors (located in prostate and bladder) blocker that works by blocking the action of alpha-1 receptors and causes smooth muscle relaxation in the bladder and prostate. Dutasteride belongs to a class of 5-alpha reductase that works by blocking the action of a 5-alpha reductase enzyme, resulting in a shrink of the size of the prostate gland. Silodosin+dutasteride reduces the BPH symptoms and improves your ability to urinate.
Take Silodosin+dutasteride as prescribed. Your doctor will recommend how often you take Silodosin+dutasteride based on your medical condition. In some cases, you may experience certain common side effects such as dizziness, headache, nasal congestion (stuffy nose), and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
To treat your condition effectually continue taking Silodosin+dutasteride for as long as your doctor has prescribed it. Try not to stop taking it on your own. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Silodosin+dutasteride. Avoid consumption of alcohol as it may increase the side effects like dizziness and low blood pressure. If you take Silodosin+dutasteride with any antihypertensive medicine, your blood pressure could suddenly drop to s life-threatening level. So avoid intake of Silodosin+dutasteride with antihypertensive drugs.
Uses of Silodosin+dutasteride
Medicinal Benefits
Silodosin+dutasteride is a combination of two drugs, namely; Silodosin and Dutasteride used to treat the symptoms of benign prostatic hyperplasia (BPH) in adults with an enlarged prostate gland. Silodosin belongs to a class of alpha-1 receptors (located in prostate and bladder) blocker that works by blocking the action of alpha-1 receptors and causes smooth muscle relaxation in the bladder and prostate. Dutasteride belongs to a class of 5-alpha reductase that works by blocking the action of a 5-alpha reductase enzyme, resulting in a shrink of the size of the prostate gland. Silodosin+dutasteride reduces the BPH symptoms and improves your ability to urinate.
Directions for Use
Storage
Side Effects of Silodosin+dutasteride
- Headache
- Dizziness
- Nasal congestion (stuffy nose)
- Diarrhoea
- Ejaculation disorder
- Retrograde ejaculation
- Impotence
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
In-Depth Precautions and Warning
Drug Warnings
Do not take Silodosin+dutasteride if you are allergic to Silodosin+dutasteride and ingredients in it. Consult your doctor before taking Silodosin+dutasteride if you are taking medicines for the treatment of hypertension (high blood pressure). If you take Silodosin+dutasteride with any antihypertensive medicine your blood pressure could suddenly drop to a life-threatening level. So avoid intake of Silodosin+dutasteride with antihypertensive drugs. Do not take Silodosin+dutasteride if you have/had a heart attack or stroke or heart failure, low blood pressure, kidney or liver disease, have certain eye diseases, loss of vision due to loss of blood flow to the optic (eye) nerve. You are advised not to drive or operate heavy machinery after taking Silodosin+dutasteride as it may cause dizziness. Avoid consuming alcohol along with Silodosin+dutasteride as it could lead to increased dizziness and drowsiness. Older patients may be more sensitive to the side effects of Silodosin+dutasteride, especially dizziness and low blood pressure when getting up from a sitting or lying position. Silodosin+dutasteride should not be given to women and children less than 18 years of age.
Drug Interactions
Drug-Drug Interaction: Silodosin+dutasteride interacts with medicines used to treat high blood pressure (prazosin, terazosin), drugs used to treat erectile dysfunction (sildenafil, tadalafil), azole antifungals (itraconazole, ketoconazole), HIV protease inhibitor (lopinavir, ritonavir).
Drug-Food Interaction: Silodosin+dutasteride may interact with grapefruit juice, alcohol, and tobacco. This may cause more side effects than it normally does. So, a Silodosin+dutasteride should not be taken along with them.
Drug-Disease Interaction: Silodosin+dutasteride should not be taken in patients with heart problems, low blood pressure, kidney or liver disease, have certain eye diseases, loss of vision due to loss of blood flow to the optic (eye) nerve.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are advised not to consume alcohol while taking Silodosin+dutasteride as it makes you pee more and can irritate your bladder and also increased dizziness and lower blood pressure.
Pregnancy
unsafeWomen should not use Silodosin+dutasteride as it is used to treat benign prostatic hyperplasia (BPH) in men only.
Breast Feeding
unsafeWomen should not use Silodosin+dutasteride as it is used to treat benign prostatic hyperplasia (BPH) in men only.
Driving
cautionSilodosin+dutasteride may cause dizziness. Therefore you are advised to drive and operate machinery only if you are alert.
Liver
cautionSilodosin+dutasteride should be used with caution in patients with liver disease. The dose adjustment may be needed in such patients.
Kidney
cautionSilodosin+dutasteride should be used with caution in patients with kidney disease. The dose adjustment may be needed in such patients.
Children
cautionSilodosin+dutasteride is not recommended for children below 18 years of age.
Habit Forming
Diet & Lifestyle Advise
- Maintaining a healthy weight, eating a balanced diet, and regular exercising may help your bladder empty at a normal rate.
- Avoid consumption of alcohol to treat your condition effectively as consuming an excessive amount of alcohol may make you pee more and can irritate your bladder.
- Limit the amount of fluids and caffeine you drink, especially before you go out or go to bed.
- Stay warm, cold can make it feel more urgent to pee.
- Avoid usage of tobacco.
- Do daily exercise to strengthen your pelvic floor muscles.
Special Advise
- Regularly monitor blood pressure is required while taking Silodosin+dutasteride.
Patients Concern
Disease/Condition Glossary
Benign Prostatic Hyperplasia (BPH): is an enlargement of the prostate gland. The prostate is a small, muscular gland in the male reproductive system. It is a common condition as men get older (50-60 years). It occurs when the cells of the prostate gland begin to multiply. In an enlarged prostate gland, the bladder wall becomes thicker, and the bladder may weaken and lose the ability to empty fully, leaving some urine in the bladder. Symptoms of BPH include frequent or urgent need to urinate, nocturia (increased frequency of urination at night, difficulty starting urination, inability to empty the bladder, painful urination, blood in the urine.
FAQs
Silodosin+dutasteride is a combination of two drugs, namely; Silodosin and Dutasteride used to treat the symptoms of benign prostatic hyperplasia (BPH) in adults with an enlarged prostate gland. Silodosin belongs to a class of alpha-1 receptors (located in prostate and bladder) blocker that works by blocking the action of alpha-1 receptors and causes smooth muscle relaxation in the bladder and prostate. Dutasteride belongs to a class of 5-alpha reductase that works by blocking the action of a 5-alpha reductase enzyme, resulting in a shrink of the size of the prostate gland. Silodosin+dutasteride reduces the BPH symptoms and improves your ability to urinate.
No, Silodosin+dutasteride should not be taken along with blood-pressure-lowering medicines. Silodosin+dutasteride may cause a sudden drop in your blood pressure which could lead to dizziness or fainting. Therefore, if Silodosin+dutasteride is taken along with blood pressure lowering medicines, it could lead to a severe decrease in blood pressure which could be lethal.
Yes, Silodosin+dutasteride may cause dizziness. You are advised not to drive or operate heavy machinery after taking Silodosin+dutasteride as it may cause dizziness. Drive or operate machinery only if you are alert.
No, Silodosin+dutasteride should not be taken by women. It is intended to treat symptoms of benign prostatic hyperplasia (BPH) in adult men only.
No, you are advised not to consume alcohol while taking Silodosin+dutasteride as it makes you pee more and can irritate your bladder and also increase dizziness and lower blood pressure. Therefore, you are advised not to consume excessive amounts of alcohol while taking Silodosin+dutasteride.
