Tadalafil+dapoxetine
About
Tadalafil+dapoxetine is a combination drug containing 'impotent agents', primarily used to treat erectile dysfunction (impotence) and premature ejaculation in men. Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Premature ejaculation is a very common sexual complaint. It is a problem in which a man ejaculates sooner than his partner during sexual intercourse.
Tadalafil+dapoxetine contains Tadalafil and Dapoxetine used to treat premature ejaculation in men. Tadalafil works by inhibiting the phosphodiesterase enzyme, which leads to the breakdown of cGMP and causes relaxation of smooth muscles and vasodilation (widening) of blood vessels in the penis. Thereby, it helps to treat erectile dysfunction and symptoms of an enlarged prostate. Dapoxetine works by increasing the serotonin level in nerves, which improves control over ejaculation and hence increases the time taken to ejaculate.
Take Tadalafil+dapoxetine as prescribed by your doctor. You are advised to take Tadalafil+dapoxetine for as long as your doctor has prescribed it for you, depending upon your medical condition. In some cases, you may experience nausea, dizziness, vomiting, dryness in the mouth, indigestion, nosebleeds, headache, flushing (sense of warmth in the face, ears, neck, and trunk). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Do not take Tadalafil+dapoxetine if you take nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension), or alpha-blockers, if you have heart problems or stroke, low, or uncontrolled high blood pressure. Tadalafil+dapoxetine is not intended for use in women. Tadalafil+dapoxetine may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil+dapoxetine should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side-effects. Do not take Tadalafil+dapoxetine if you have taken MAO inhibitor (a medication for depression) in the last 14 days.
Uses of Tadalafil+dapoxetine
Medicinal Benefits
Tadalafil+dapoxetine is a combination drug containing 'impotent agents', primarily used to treat erectile dysfunction (impotence) and premature ejaculation in men. Tadalafil+dapoxetine contains Tadalafil and Dapoxetine. Tadalafil works by inhibiting the phosphodiesterase enzyme, which leads to the breakdown of cGMP and causes relaxation of smooth muscles and vasodilation (widening) of blood vessels in the penis. Thereby, it helps to treat erectile dysfunction and symptoms of an enlarged prostate. Dapoxetine works by increasing the serotonin level in nerves, which improves control over ejaculation and increases the time taken to ejaculate.
Directions for Use
Storage
Side Effects of Tadalafil+dapoxetine
- Nausea
- Dizziness
- Vomiting
- Dryness in mouth
- Indigestion
- Nosebleeds
- Headache
- Flushing (sense of warmth in the face, ears, neck, and trunk)
In-Depth Precautions and Warning
Drug Warnings
Do not take Tadalafil+dapoxetine if you are allergic to any of its contents; if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension), or alpha-blockers; if you have heart problems or stroke, low blood pressure, or uncontrolled high blood pressure, if you ever had a loss of vision. Inform your doctor before taking Tadalafil+dapoxetine if you have sickle cell anemia (abnormal red blood cells), multiple myeloma (cancer of bone marrow), leukemia (blood cell cancer), deformation in penis, severe kidney or liver problems. Consult your doctor immediately if you experience loss of vision or hearing while taking Tadalafil+dapoxetine. Tadalafil+dapoxetine is not intended for use in women. Tadalafil+dapoxetine may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil+dapoxetine should not be given to children as safety and effectiveness have not been established. Do not take Tadalafil+dapoxetine if you have taken an MAO inhibitor (anti-depressant medication like Isocarboxazid, Phenelzine, Selegiline, and Tranylcypromine) in the last 14 days.
Drug Interactions
Drug-Drug Interactions: Tadalafil+dapoxetine may have interaction with anti-hypertensive (amlodipine, lisinopril, losartan, metoprolol, riociguat), alpha-blockers (tamsulosin), anti-anginal (nitroglycerin), anti-fungal (ketoconazole, itraconazole), antibiotics (erythromycin, clarithromycin), anti-TB (rifampicin), anticonvulsants (phenobarbital, phenytoin, carbamazepine), anti-HIV (ritonavir, saquinavir, nelfinavir), pain-killers (tramadol), anti-depressants (lithium, nefazodone), MAO inhibitor (Isocarboxazid, Phenelzine, Selegiline, and Tranylcypromine).
Drug-Food Interactions: Avoid consumption of alcohol as it may temporarily impair your ability to get an erection. Also, do not take St John's wort plant (a natural remedy to treat depression).
Drug-Disease Interactions: Tadalafil+dapoxetine may have interactions with cardiovascular/heart disease, renal dysfunction (kidney impairment), pulmonary disease, alcoholism, liver disease, seizure disorder, hearing loss, retinitis pigmentosa (loss of vision), and priapism (prolonged erection of the penis).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionYou are advised not to consume alcohol while taking Tadalafil+dapoxetine as it may cause increases dizziness.
Pregnancy
unsafeTadalafil+dapoxetine contains Tadalafil, which belongs to pregnancy category B. Tadalafil+dapoxetine is not intended for use in women.
Breast Feeding
unsafeTadalafil+dapoxetine is not intended for use in women.
Driving
cautionTadalafil+dapoxetine may cause dizziness. Therefore you are advised to drive and operate machinery only if you are alert.
Liver
cautionDose adjustment may be needed. Please consult your doctor before taking Tadalafil+dapoxetine if you have liver impairment/liver disease or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Please consult your doctor before taking Tadalafil+dapoxetine if you have kidney impairment/kidney disease or any concerns regarding this.
Children
unsafeTadalafil+dapoxetine should not be given to children as safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Maintaining a healthy weight, eating a balanced diet, and regularly exercising may help you manage erectile dysfunction.
- Avoid alcohol consumption to treat your condition effectively, as consuming an excessive amount of alcohol may temporarily impair your ability to get an erection.
- Avoid usage of tobacco.
- Share intimate time with your partner.
- Stay sexually active to prevent further problems with erectile dysfunction.
Special Advise
- Take Tadalafil+dapoxetine 30minutes to 4 hours before sexual intercourse. However, it is best to take it an hour before sexual activity.
- Do not take Tadalafil+dapoxetine more than once in a day. Take Tadalafil+dapoxetine as prescribed by the doctor.
- Talk to your doctor if the erection persists for greater than four hours.
Patients Concern
Disease/Condition Glossary
Erectile dysfunction: It is the inability to keep a hard and erect penis suitable for sexual intercourse. It could sign physical or psychological conditions such as fear of sexual failure, anxiety, depression, low self-esteem, or stress. Certain health-related factors such as smoking, drinking, overweight, being physically inactive, and high blood pressure also contribute to erectile dysfunction. Symptoms of erectile dysfunction include difficulty in getting an erection, difficulty in maintaining the erection during intercourse, and decreased sexual desire.
Premature ejaculation: It is a problem in which a man ejaculates sooner than his partner during sexual intercourse. It is a very common sexual complaint and generally occurs one in every three men. If it occurs infrequently, then it is not a problem of concern, but if you are unable to delay ejaculation, ejaculate within one minute of penetration, then it is a problem. It can be both due to biological and psychological factors.
FAQs
Tadalafil+dapoxetine works by relaxing the blood vessels in the penis, thereby allows the blood flow into the penis when the person is sexually excited.
Yes, the use of Tadalafil+dapoxetine can cause dry mouth. If you experience dry mouth or feel excessively thirsty, drink plenty of water, and increase fluids intake. You may also keep a lip balm with you if your lips are also dry.
No, do not take Tadalafil+dapoxetine with nitrates. Taking Tadalafil+dapoxetine with medicines used to treat angina/chest pain such as nitrates/nitroglycerin may cause severe lowering of blood pressure. You are advised not to take Tadalafil+dapoxetine if you are taking nitrates or having a history of heart attack/stroke.
No, Tadalafil+dapoxetine should not be taken along with blood-pressure-lowering medicines. Tadalafil+dapoxetine relaxes and widens the blood vessels, this causes a decrease in blood pressure. Therefore, if Tadalafil+dapoxetine is taken and blood pressure lowering medicines, it could lead to a severe blood pressure decrease.
It usually takes 30-60 minutes for Tadalafil+dapoxetine to show its effect. You should be able to get an erection at any time between 30 minutes to 36 hours after taking Tadalafil+dapoxetine. However, you need to be sexually excited for Tadalafil+dapoxetine to work.
No, it is recommended not to take Tadalafil+dapoxetine along with MAO inhibitor (a medicine for depression) as Tadalafil+dapoxetine contains Dapoxetine, which is known to contra-indicate if taken along with MAO inhibitor. So, concurrent use of Tadalafil+dapoxetine and MAO inhibitor should be avoided, and a gap of 14 days should be maintained between the last dose of MAO inhibitor and the first dose Tadalafil+dapoxetine.
