Thyrotropin
About
Thyrotropin is a human thyroid-stimulating hormone (TSH). Thyrotropin is indicated for use as an adjunctive diagnostic tool for serum thyroglobulin (Tg) testing with or without radioiodine imaging in the follow-up of patients with well-differentiated thyroid cancer who have previously undergone thyroidectomy.
Thyrotropin injection contains recombinant human thyroid-stimulating hormone (TSH). It works by stimulating the remaining thyroid tissue to take up iodine which is important for radioiodine imaging. It also stimulates the production of thyroglobulin and thyroid hormones if any thyroid tissue is left. These hormones can be measured in your blood.
Thyrotropin is available in the form of lyophilized powder and must be reconstituted with Sterile Water for Injection. Thyrotropin should be prepared and administered by a health care professional based on the medical condition and requirement. Thyrotropin usually does not have major side effects. Sometimes, it may cause nausea, headache, fatigue, vomiting, dizziness and asthenia. Most of these side effects of Thyrotropin do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Do not self-administer. Thyrotropin should be used by physicians knowledgeable in managing patients with thyroid cancer. Thyrotropin should be administered intramuscularly only. Thyrotropin should not be administered intravenously. It is also unknown whether Thyrotropin can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Thyrotropin should be given to a pregnant woman only if needed. Caution should be exercised when Thyrotropin is administered to a nursing woman. Thyrotropin can’t be used in children as safety and effectiveness in paediatric patients have not been established.
Uses of Thyrotropin
Medicinal Benefits
Thyrotropin is indicated for use as an adjunctive diagnostic tool for serum thyroglobulin (Tg) testing. Thyrotropin injection contains recombinant human thyroid-stimulating hormone (TSH). It works by stimulating the remaining thyroid tissue to take up iodine which is important for radioiodine imaging. It also stimulates the production of thyroglobulin and thyroid hormones if any thyroid tissue is left. These hormones can be measured in your blood.
Directions for Use
Storage
Side Effects of Thyrotropin
- Nausea
- Headache
- Fatigue
- Vomiting
- Dizziness
- Asthenia
- Thyrogen-Induced Hyperthyroidism
- Stroke
- Sudden Rapid Tumor Enlargement
In-Depth Precautions and Warning
Drug Warnings
Do not self-administer. Thyrotropin should be used by physicians knowledgeable in the management of patients with thyroid cancer. Thyrotropin should be administered intramuscularly only. Thyrotropin should not be administered intravenously. It is also unknown whether Thyrotropin can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Thyrotropin should be given to a pregnant woman only if clearly needed. Caution should be exercised when Thyrotropin is administered to a nursing woman. Thyrotropin can’t use in children as there is no Safety and effectiveness in paediatric patients have not been established. Inform your doctor if you have renal Impairment. The elimination of Thyrotropin is significantly slower in dialysis-dependent end-stage renal disease patients, resulting in prolonged TSH levels.
Drug Interactions
Drug-Drug Interactions: No interactions found. Please consult with your doctor for a list of contraindications.
Drug-Food Interactions: Avoid alcohol consumption to avoid unpleasant side effects.
Drug-Disease Interactions: Brief your doctor if you have a medical history of allergic reactions to medicines and kidney diseases before taking Thyrotropin.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionYou are recommended not to consume alcohol along with Thyrotropin to avoid unpleasant side-effects.
Pregnancy
cautionIt is unknown whether Thyrotropin can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Thyrotropin should be given to a pregnant woman only if clearly needed.
Breast Feeding
cautionCaution should be exercised when Thyrotropin is administered to a nursing woman. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing it to you.
Driving
cautionThyrotropin may cause dizziness and headaches after administration of Thyrotropin, which may affect the ability to drive and use machines.
Liver
cautionThyrotropin to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Kidney
cautionThyrotropin should be taken with caution, especially if you have a history of Kidney diseases/conditions. Elimination of Thyrotropin is significantly slower in dialysis-dependent end-stage renal disease patients, resulting in prolonged elevation of TSH levels.
Children
cautionThyrotropin should be given to children only in exceptional circumstances. Your child’s doctor will help you decide if Thyrotropin should be given to your child.
Habit Forming
Diet & Lifestyle Advise
- Eat a healthy diet and exercise regularly to maintain proper weight.
- Avoid smoking and alcohol consumption.
- Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs in your diet.
- Avoid fast food, fried food, processed meats, refined carbs, and added sugars.
- Get optimal sleep; rest well.
Special Advise
- Regularly monitor your blood tests done to monitor your liver function, electrolyte levels, blood cell count in your blood.
- Avoid unnecessary or prolonged exposure to sunlight and UV light (such as tanning booths) and wear protective clothing, sunglasses, and sunscreen. Thyrotropin may make your skin sensitive to sunlight.
- Thyrotropin should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Thyrotropin.
- Consult a doctor immediately if you notice any signs of infection, fever, diarrhoea, chills, etc.
Patients Concern
Disease/Condition Glossary
Thyroid cancer: Thyroid cancer is cancer that develops from the tissues of the thyroid gland. It is a disease in which cells grow abnormally and can spread to other parts of the body. Symptoms can include swelling or a lump in the neck.
Thyroglobulin test: The thyroglobulin test measures the level of thyroglobulin in your blood. A thyroglobulin test is mostly used as a tumour marker test to help guide thyroid cancer treatment.
FAQs
Thyrotropin injection contains recombinant human thyroid-stimulating hormone (TSH). It stimulates the production of thyroglobulin and thyroid hormones if there is any thyroid tissue left. These hormones can be measured in your blood.
The thyroglobulin test is primarily used as a tumour marker test to aid in thyroid cancer treatment. This test calculates how much thyroglobulin is in your blood.
The effect of Thyrotropin on long term thyroid cancer outcomes has not been determined. When Thyrotropin is used to help detect thyroid cancer, there is still a chance all or parts of cancer could be missed.
If Thyrotropin is administered with radioiodine, the contraindications to radioiodine also apply to this combination regimen.
While taking Thyrotropin, make sure you visit your doctor at all the appointments to ensure that treatment is working. Regular monitoring of blood and urine tests, weight checks are required.
